Dose-dependent effects of lanthanum chloride on wear particle-induced aseptic inflammation in a murine air-pouch model

Jiang, Chuan; Zou, Yang; Liu, Xiang; Shang, Jiangyinzi; Cheng, Ming; Dai, Min

doi:10.1016/s1002-0721(12)60298-1

Cited by 8 publications

(10 citation statements)

References 41 publications

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“…The specific primary antibodies and secondary antibodies used in the experiments were provided by Cell Signaling Technology (Danvers, MA, USA). Titanium (Ti) particles (99.99% purity, 1e3 mm in diameter) were provided by Johnson Matthey Company (Ward Hill, MA, USA) and prepared as previously described [16]. Briefly, possible endotoxin adhering to the particles was removed by treating with 70% ethanol for 48 h and heating at 250 C for 3 h. The particle endotoxin level was then detected (<0.02 EU/mL) using the limulus amebocyte lysate assay.…”

Section: Reagents and Titanium Particlesmentioning

confidence: 99%

Inhibitory effects of ursolic acid on osteoclastogenesis and titanium particle-induced osteolysis are mediated primarily via suppression of NF-κB signaling

Jiang

Xiao

et al. 2015

Biochimie

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Section: Reagents and Titanium Particlesmentioning

confidence: 99%

Inhibitory effects of ursolic acid on osteoclastogenesis and titanium particle-induced osteolysis are mediated primarily via suppression of NF-κB signaling

Jiang

Xiao

et al. 2015

Biochimie

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“…The introduction of molybdate slowed down the reduction rate of Ni ions and the peak potential increased. Judging from the peak current value of Curve 2, the reduction of MoO 4 2− ions belongs to the multi-step reduction process, corresponding to Mo 4+ peak at e and Mo 3+ peak at d [19][20][21]. The voltage value shows a delay effect during the formation of the deposition of metal atoms, while the width of the voltage interval provides time for the further deposition of metal atoms.…”

Section: Analysis Of Metal Ion Activitymentioning

confidence: 99%

Electrodeposition Behavior of Polycrystalline Ni–Mo–La Composite in Alkaline Solution

Chen

et al. 2018

Coatings

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Abstract:The polycrystalline Ni-Mo-La composite coating was obtained by electrodeposition through the addition of La 3+ ions into Ni, Mo ions main salt weak alkaline solution. The obtained composite contain 0.92 at.% La. According to the law of ionic activity, the redox reaction of three kinds of metal atoms was studied by polarography and cyclic voltammetry. It was found that the addition of lanthanum ions changed the composite structural, phase, and element, and the OH − ions were deduced during the electrodeposition in alkaline solution. The introduction of lanthanum and molybdenum ions negatively shifted the reduction potential of nickel ions and broadened the peaks significantly in the deposition process, retarding the reduction and deposition rate of Ni ions, which was characterized by a multi-step reduction process of Mo and La metal atoms.

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“…Three different models of osteolysis were adopted: air-pouch [16,29,33,56,57,58,59,60], calvarial [18,53,61,62,63,64] and pin-implantation [65] models. One study compared two methods to induce osteolysis in vivo: fluid pressure and particle injection [55].…”

Section: Gene Expression In Osteolysismentioning

confidence: 99%

“…Opposite to what was observed in vitro, these in vivo studies used only two types of wear particles: Ti [16,29,33,53,55,56,57,58,59,60,64,65], the most employed ones, and PE [18,61,62,63]. The size of Ti particles ranged between 0.1 and 20 µm while PE particles were 7 [61,62,63] or 5.1 [18] µm.…”

Section: Gene Expression In Osteolysismentioning

confidence: 99%

“…The size of Ti particles ranged between 0.1 and 20 µm while PE particles were 7 [61,62,63] or 5.1 [18] µm. The amount of Ti particles varied from 10 to 150 mg/mL in the murine air-pouch model [16,29,33,53,56,57,58,59,60,65] to 300 mg/mL in the murine calvarial model [64]. The amount of PE was between 0.5 and 20 mg/mL [18,61,62,63] (Table 2).…”

Section: Gene Expression In Osteolysismentioning

confidence: 99%

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Gene Expression in Osteolysis: Review on the Identification of Altered Molecular Pathways in Preclinical and Clinical Studies

Veronesi

Tschon

Fini

2017

IJMS

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Aseptic loosening (AL) due to osteolysis is the primary cause of joint prosthesis failure. Currently, a second surgery is still the only available treatment for AL, with its associated drawbacks. The present review aims at identifying genes whose expression is altered in osteolysis, and that could be the target of new pharmacological treatments, with the goal of replacing surgery. This review also aims at identifying the molecular pathways altered by different wear particles. We reviewed preclinical and clinical studies from 2010 to 2016, analyzing gene expression of tissues or cells affected by osteolysis. A total of 32 in vitro, 16 in vivo and six clinical studies were included. These studies revealed that genes belonging to both inflammation and osteoclastogenesis pathways are mainly involved in osteolysis. More precisely, an increase in genes encoding for the following factors were observed: Interleukins 6 and 1β (IL16 and β), Tumor Necrosis Factor α (TNFα), nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1), Cathepsin K (CATK) and Tartrate-resistant acid phosphatase (TRAP). Titanium (Ti) and Polyethylene (PE) were the most studied particles, showing that Ti up-regulated inflammation and osteoclastogenesis related genes, while PE up-regulated primarily osteoclastogenesis related genes.

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Dose-dependent effects of lanthanum chloride on wear particle-induced aseptic inflammation in a murine air-pouch model

Cited by 8 publications

References 41 publications

Inhibitory effects of ursolic acid on osteoclastogenesis and titanium particle-induced osteolysis are mediated primarily via suppression of NF-κB signaling

Inhibitory effects of ursolic acid on osteoclastogenesis and titanium particle-induced osteolysis are mediated primarily via suppression of NF-κB signaling

Electrodeposition Behavior of Polycrystalline Ni–Mo–La Composite in Alkaline Solution

Gene Expression in Osteolysis: Review on the Identification of Altered Molecular Pathways in Preclinical and Clinical Studies

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