2013
DOI: 10.4049/jimmunol.1200506
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Dose-Dependent Effects of IL-17 on IL-13–Induced Airway Inflammatory Responses and Airway Hyperresponsiveness

Abstract: The Th2 cytokine IL-13 regulates several aspects of the asthmatic phenotype, including airway inflammation, airway hyperresponsiveness, and mucus production. The Th17 cytokine IL-17A is also implicated in asthma and has been shown to both positively and negatively regulate Th2-dependent responses in murine models of allergic airways disease. Our objective in this study was to better understand the role of IL-17 in airway inflammation by examining how IL-17 modifies IL-13–induced airway inflammatory responses. … Show more

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Cited by 58 publications
(68 citation statements)
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“…The expression of CD209a is highly upregulated in response to IL-4 or IL-13 [38,59,60], suggesting the potential for a amplification of IL-17 responses by type 2 cytokines. This is consistent with data in which instillation of IL-13 induces IL-17 producing CD4+ and gd T cells [61 ]. These observations that type 2 cytokines promote IL-17 production contrasts sharply with the previously described ability of type 2 cytokines to negatively regulate the IL-17 response [26 ,55 ,56] but this may reflect an important negative feedback loop.…”
Section: Il-17 and Type 2 Cytokinessupporting
confidence: 87%
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“…The expression of CD209a is highly upregulated in response to IL-4 or IL-13 [38,59,60], suggesting the potential for a amplification of IL-17 responses by type 2 cytokines. This is consistent with data in which instillation of IL-13 induces IL-17 producing CD4+ and gd T cells [61 ]. These observations that type 2 cytokines promote IL-17 production contrasts sharply with the previously described ability of type 2 cytokines to negatively regulate the IL-17 response [26 ,55 ,56] but this may reflect an important negative feedback loop.…”
Section: Il-17 and Type 2 Cytokinessupporting
confidence: 87%
“…innate lymphoid cells including gd cells vs adaptive Th17/Th2) [61 ]. Nonetheless, a general story in which early neutrophil-IL-17 activation initiates events that promote a subsequent type 2 response, which in turn suppresses excessive neutrophilia is likely to be common.…”
Section: Il-17 and Type 2 Cytokinesmentioning
confidence: 99%
“…Several cell types, including Th17 cells [24,31], γδ T cells [27,28] and alveolar macrophages [32] have been identified as sources of IL-17 in murine models of allergic airways disease. Following OVA challenge, we identified the major IL-17 producing cell(s) in both the BAL and lungs of OVA/sal, OVA/alum and OVA/CFA sensitized mice.…”
Section: Resultsmentioning
confidence: 99%
“…We therefore considered other mediators to provide a possible explanation for the disconnect between AHR and inflammation observed in OVA/CFA mice. The ability of IL-17 to act as both a positive and negative regulator of asthma [27], as well as the ability of CFA to induce IL-17 in models of experimental autoimmune encephalomyelitis [45] made this particular cytokine a strong candidate. While IL-17 alone may not induce AHR in mice, under some circumstances it can promote Th2-dependent AHR and inflammation [26].…”
Section: Discussionmentioning
confidence: 99%
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