Dose-Dependent Effects of Evening Primrose Oil in Children and Adolescents with Atopic Dermatitis

Chung, Bo Young; Kim, Jin Hye; Cho, Soo Ick; Ahn, In Su; Kim, Hye One; Park, Chun Wook; Lee, Cheol Heon

doi:10.5021/ad.2013.25.3.285

Cited by 14 publications

(15 citation statements)

References 26 publications

(37 reference statements)

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“…In another study conducted with 40 children with AD, where the patients were divided into a 160 mg EPO supplementation group and a 320 mg EPO supplementation group, the EASI score improved and the blood LA level significantly increased in both groups. This change was more distinctive in the high-dose group, suggesting a dose-dependent effect 28 . These previous studies conducted with Koreans showed a beneficial effect of EPO in AD.…”

Section: Discussionmentioning

confidence: 83%

Effect of Evening Primrose Oil on Korean Patients With Mild Atopic Dermatitis: A Randomized, Double-Blinded, Placebo-Controlled Clinical Study

et al. 2018

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BackgroundAtopic dermatitis (AD) is related to a deficiency of delta-6-desaturase, an enzyme responsible for converting linoleic acid to gamma-linolenic acid (GLA). Evening primrose oil (EPO) as a source of GLA has been of interest in the management of AD.ObjectiveThe aim of this randomized, double-blinded, placebo-controlled clinical study is to evaluate the efficacy and safety of EPO in Korean patients with AD.MethodsFifty mild AD patients with an Eczema Area Severity Index (EASI) score of 10 or less were enrolled and randomly divided into two groups. The first group received an oval unmarked capsule containing 450 mg of EPO (40 mg of GLA) per capsule, while placebo capsules identical in appearance and containing 450 mg of soybean oil were given to the other group. Treatment continued for a period of four months. EASI scores, transepidermal water loss (TEWL), and skin hydration were evaluated in all the AD patients at the baseline, and in months 1, 2, 3, and 4 of the study.ResultsAt the end of month 4, the patients of the EPO group showed a significant improvement in the EASI score (p=0.040), whereas the patients of the placebo group did not. There was a significant difference in the EASI score between the EPO and placebo groups (p=0.010). Although not statistically significant, the TEWL and skin hydration also slightly improved in the EPO patients group.ConclusionWe suggest that EPO is a safe and effective medicine for Korean patients with mild AD.

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Section: Discussionmentioning

confidence: 83%

Effect of Evening Primrose Oil on Korean Patients With Mild Atopic Dermatitis: A Randomized, Double-Blinded, Placebo-Controlled Clinical Study

et al. 2018

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“…For each year, apart from 2004 and 2008, there were either one or two studies that had failed to compare the hypothesis correctly. The interventions of three quarters of the studies were non-pharamacological [ 8 , 10 , 11 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Resultsmentioning

confidence: 99%

“…A third of the studies ( n = 4) mentioned in their statistical methods section that that they would compare groups [ 12 , 14 , 17 , 18 ]. One paper stated at the onset that their study had not been designed to do hypothesis testing, but rather to describe pharmacokinetic profiles and to perform secondary, non-statistical evaluations of local tolerability, safety and efficacy of the drugs.…”

Section: Resultsmentioning

confidence: 99%

How Often Do Comparative Randomised Controlled Trials in the Field of Eczema Fail to Directly Compare the Treatments Being Tested?

Ratib

Wilkes

Nankervis

et al. 2015

JCM

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The objective of the study was to identify all parallel design randomised controlled trials (RCTs) comparing treatments for eczema in recent dermatology literature that have failed to report a between-group analysis. The GREAT database () was searched to identify parallel group RCTs comparing two or more interventions published in the English language in the last decade, 2004 to 2013. The primary outcome was the number of studies that had not reported a between-group analysis for any of the outcomes. Where possible we re-analysed the data to determine whether a between-group analysis would have given a different conclusion to that reported. Out of a total of 304 RCTs in the study period, 173 (56.9%) met the inclusion criteria. Of the 173 eligible studies, 12 (6.9%) had not conducted a between-group analysis for any of the reported outcomes. There was no clear improvement over time. Five of the eight studies that were re-analysed yielded non-significant between-group differences yet reported significant within-group comparisons. All but one of the 12 studies implied that the experimental intervention was successful despite not undertaking any between-group comparisons. Although the proportion of all RCTs that fail to report an appropriate between-group analysis is small, the fact that any scientist who purports to compare one treatment against another then chooses to omit the key comparison statistic is worrying.

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“…In a diet-fed, AD, hairless mouse model, only supplementation with ω-6, but not ω-3, fatty acid reduced AD symptoms, such as itch-related scratching and skin inflammation. However, there is currently insufficient evidence of beneficial effects from clinical trials with evening primrose or borage oil (15)(16)(17)44). Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Although omega (ω)-6-fatty acid supplementation, mainly evening primrose or borage oil, has been used as an alternative treatment option (15)(16)(17), there is currently insufficient evidence to show beneficial effects of oral supplementation on disease severity in patients with AD. Furthermore, the beneficial effects of topical ω-6 fatty acids have not been evaluated in larger clinical trials.…”

mentioning

confidence: 99%

Effects of Topical Tacrolimus and Polyunsaturated Fatty Acids on In Vivo Release of Eicosanoids in Atopic Dermatitis During Dermal Microdialysis

Quist¹,

Wiswedel²,

Doering³

et al. 2016

Acta Derm Venerol

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Atopic dermatitis (AD) is a multifactorial inflammatory skin disease with release of distinct inflammatory signals. This study investigated the presence of eicosanoids in AD skin and the effect of topical agents with potential to suppress inflammation. Twelve patients with moderate AD received topical treatment on either arm with tacrolimus 0.1% ointment or a lotion containing 12% ω-6 fatty acids (polyunsaturated fatty acids; PUFA) twice daily for 5 consecutive days. Interstitial fluid was collected in vivo via dermal microdialysis from 4 defined skin areas: lesional, non-lesional and topically treated skin (tacrolimus or PUFA). Markers of oxidative stress (F2-isoprostanes; 5- and 8-prostaglandin F2α) and inflammation (9α,11α-prostaglandin F2α; and prostaglandin E2) were determined by gas chromatography-mass spectrometry. All eicosanoid levels were reduced in non-lesional and tacrolimus-treated skin. A significant reduction was observed in total F2-isoprostanes; 9α,11α-prostaglandin F2α; and prostaglandin E2 in non-lesional skin and in 9α,11α-prostaglandin F2α in tacrolimus-treated compared with untreated AD skin. In conclusion, treatment with tacrolimus compared with PUFA appears to suppress eicosanoids more efficiently in AD skin.

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Dose-Dependent Effects of Evening Primrose Oil in Children and Adolescents with Atopic Dermatitis

Cited by 14 publications

References 26 publications

Effect of Evening Primrose Oil on Korean Patients With Mild Atopic Dermatitis: A Randomized, Double-Blinded, Placebo-Controlled Clinical Study

Effect of Evening Primrose Oil on Korean Patients With Mild Atopic Dermatitis: A Randomized, Double-Blinded, Placebo-Controlled Clinical Study

How Often Do Comparative Randomised Controlled Trials in the Field of Eczema Fail to Directly Compare the Treatments Being Tested?

Effects of Topical Tacrolimus and Polyunsaturated Fatty Acids on In Vivo Release of Eicosanoids in Atopic Dermatitis During Dermal Microdialysis

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