Dose-dependent effects of butylated hydroxyanisole, butylated hydroxytoluene and ethoxyquin in induction of foci of rat liver cells containing the placental form of glutathione S-transferase

Thamavit, Witaya; Tatematsu, Masae; Ogiso, Tadashi; Mera, Yukinori; Tsuda, Hiroyuki; Ito, Nobuyuki

doi:10.1016/0304-3835(85)90187-9

Cited by 35 publications

(13 citation statements)

References 16 publications

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“…Recent epidemiological studies indicated that a high intake of antioxidants was positively associated with the reduced risk of coronary heart diseases and ageingrelated diseases (Flora, 2007;Valko et al, 2007). However, some synthetic antioxidants such as BHA and BHT, have been revealed to be potentially toxic and carcinogenic (Thamavit et al, 1985;Williams, Shimada, McQueen, Tong, & Ved Brat, 1984). Consequently, there is an increasing interest to search for antioxidants naturally present in vegetables, fruits and functional herbs.…”

Section: Introductionmentioning

confidence: 95%

TLC bioautography-guided isolation of antioxidants from fruit of Perilla frutescens var. acuta

Wang

2009

LWT - Food Science and Technology

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Section: Introductionmentioning

confidence: 95%

TLC bioautography-guided isolation of antioxidants from fruit of Perilla frutescens var. acuta

Wang

2009

LWT - Food Science and Technology

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“…Antioxidants are one major class of such inhibitors, as shown in the Ito protocol after initiation with nitrosamines [103,[130][131][132][133]. After initiation with N-ethyl-N-hydroxyethylnitrosamine, BHA and ethoxyquin inhibit hepatocellular carcinomas, but induce renal cell adenomas [132].…”

Section: Gamma-glutamyltran~ferase As a Marker Of Preneoplastic Loci mentioning

confidence: 99%

“…PGST scores greater numexcept the DEN control [59]. qhere is much less periportal background staining with PGST than is seen with GGT staining [59], and foci are easier to identify [130].…”

Section: Placental Ghttathione S-traj~ferase As a Marker Of Preneoplamentioning

confidence: 99%

Enzymes of glutathione metabolism as biochemical markers during hepatocarcinogenesis

Hendrich

Pitot

1987

Cancer Metast Rev

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Enzymes of glutathione metabolism, particularly gamma-glutamyltransferase (GGT) and glutathione S-transferase (GST), play a role in multistage hepatocarcinogenesis. The enhanced expression of these enzymes in preneoplastic altered hepatic foci, nodules, and hepatocellular carcinomas has been demonstrated after treatment with a variety of initiating and promoting agents. Glutathione is necessary for the detoxification of xenobiotics and carcinogens and for cell replication. Induction of GGT in altered hepatocytes may permit these cells to utilize extracellular glutathione to preserve their internal glutathione levels. GST induction allows glutathione utilization for the protection of the altered hepatocyte in an environment of exposure to xenobiotics, such as promoting agents. Thus, the combined effects of GGT and GST, in a toxic environment, may provide for the enhanced proliferation observed in preneoplastic hepatocytes. New clinical and research opportunities may involve the use of GGT and the placental isozyme of GST (PGST) as markers of preneoplasia and neoplasia in humans. Many factors, such as hormones, diet, and exposure to initiating and promoting agents, influence GGT and GST expression. The recent cloning of cDNAs to GGT and PGST offers opportunities for the study of factors involved in the genetic expression of these two enzymes. Coupled with the use of hepatocyte culture and transplantation, the factors involved at the molecular level in the creation of hepatocellular neoplasia may be discovered.

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“…Recent epidemiological studies indicated that a high intake of antioxidants was positively associated with the reduced risk of coronary heart diseases and ageing related disease (Flora, 2007;Valko et al, 2007) However, some synthetic antioxidants such as butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT), have been revealed to be potentially toxic and carcinogenic (Williams et al, 1984;Thamavit et al, 1985). Therefore, there is an increasing interest to search for antioxidants naturally present in vegetables, fruits and functional herbs.…”

Section: Introductionmentioning

confidence: 97%

Comparison of extraction conditions for phenolic, flavonoid content and determination of rosmarinic acid from Perilla frutescens var. acuta

Hong¹,

Kim²

2010

International Journal of Food Science &Amp; Technology

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Perilla frutescens var. acuta has traditionally been used to treat disease including, depression, inflammation and tumors. Especially, the presence of rosmarinic acid can induce beneficial and health promoting effects. According to, this work was conducted to comparison of various extraction conditions (extraction process, solvent and time) of total phenolic, floavonoid and rosmainic acid contents from the leaves of Perilla frutescens var. acuta. Also, rosmarinic acid was determined in leaves of Perilla frutescens var. acuta by highperformance liquid chromatography (HPLC) and the described method was ideally suited for rapid routine analysis. The highest yield of total phenolic, flavonoid and rosmarinic acid was shown 12.15 mg gallic acid equivalents g )1 dry weight (DW), 7.23 mg rutin equivalents g )1 DW and 3.76 mg g )1 DW, respectively. The best condition for extraction efficiency of total phenolic, flovonoid and rosmarinic were found to be: ethanol concentration of 70%, extraction time of 24 h and extraction process of refluxed extraction.

show abstract

Dose-dependent effects of butylated hydroxyanisole, butylated hydroxytoluene and ethoxyquin in induction of foci of rat liver cells containing the placental form of glutathione S-transferase

Cited by 35 publications

References 16 publications

TLC bioautography-guided isolation of antioxidants from fruit of Perilla frutescens var. acuta

TLC bioautography-guided isolation of antioxidants from fruit of Perilla frutescens var. acuta

Enzymes of glutathione metabolism as biochemical markers during hepatocarcinogenesis

Comparison of extraction conditions for phenolic, flavonoid content and determination of rosmarinic acid from Perilla frutescens var. acuta

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