Dose‐Dependent Deficits in Dual Interstimulus Interval Classical Eyeblink Conditioning Tasks Following Neonatal Binge Alcohol Exposure in Rats

Brown, Kevin L.; Calizo, Lyngine H.; Stanton, Mark E.

doi:10.1111/j.1530-0277.2007.00579.x

Cited by 27 publications

(55 citation statements)

References 104 publications

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“…CR latencies were also earlier to the light CS. Adult (PD70) females often outperformed their male counterparts, also consistent with our previous findings (Brown et al, 2008). …”

Section: Resultssupporting

confidence: 92%

“…Consistent main or interactive effects that do not alter conclusions concerning the effects of primary interest are briefly disclosed here. Consistent with previous reports (Brown et al, 2008, 2006), SRs were more robust to the tone CS while conditioning was more robust with light as the CS. CR latencies were also earlier to the light CS.…”

Section: Resultssupporting

confidence: 92%

“…Consistent with previous findings (Brown et al, 2008; Choi & Moore, 2003; Freeman et al, 2003; Hoehler & Leonard, 1976; Joscelyne & Kehoe, 2007; Kehoe & Joscelyne, 2005; Millenson et al, 1977), CS-alone trials (particularly in long CS trials) revealed a high percentage of double-peaked CRs (approximately 50% or more) relative to single-cue controls (Brown et al, 2006) and relative to ISI discrimination conditioning (< 50%; see Table 1; Figure 7). Freeman et al also reported fewer double-peaked CRs in rats trained at PD24-26 relative to PD32-34s.…”

Section: Resultssupporting

confidence: 90%

“…Data analysis was similar to that described in previous studies (Brown et al 2008, 2006). EMG signals were sampled in 3.5 ms bins during the 1400 ms epoch of each trial type.…”

Section: Methodsmentioning

confidence: 78%

“…One day after puff testing for subjects undergoing surgery on PD21 or PD28 (PD23 and 30) and one day after context pre-exposure for subjects undergoing surgery on PD39-43 and PD60-64 (PD42-46 and PD65-71; these groups will henceforth be termed PD45 and PD70s, respectively), ISI discrimination (Experiment 1a; as described in Brown, Calizo, & Stanton, 2008; Brown et al, 2006) or temporal uncertainty training (Experiment 1b; as described in Brown et al, 2008) commenced (see Figure 1 for an illustration of the conditioning parameters). All 4 ages and both tasks were run concurrently.…”

Section: Methodsmentioning

confidence: 99%

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Cross‐Modal transfer of the conditioned eyeblink response during interstimulus interval discrimination training in young rats

Brown

Stanton

2008

Developmental Psychobiology

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Eyeblink classical conditioning (EBC) was observed across a broad developmental period with tasks utilizing two interstimulus intervals (ISIs). In ISI discrimination, two distinct conditioned stimuli (CSs; light and tone) are reinforced with a periocular shock unconditioned stimulus (US) at two different CS-US intervals. Temporal uncertainty is identical in design with the exception that the same CS is presented at both intervals. Developmental changes in conditioning have been reported in each task beyond ages when single-ISI learning is well developed. The present study sought to replicate and extend these previous findings by testing each task at four separate ages. Consistent with previous findings, younger rats (postnatal day -PD -23 and 30) trained in ISI discrimination showed evidence of enhanced cross-modal influence of the short CS-US pairing upon long CS conditioning relative to older subjects. ISI discrimination training at PD43-47 yielded outcomes similar to those in adults (PD65-71). Cross-modal transfer effects in this task therefore appear to diminish between PD30 and PD43-47. Comparisons of ISI discrimination with temporal uncertainty indicated that cross-modal transfer in ISI discrimination at the youngest ages did not represent complete generalization across CSs. ISI discrimination undergoes a more protracted developmental emergence than single-cue EBC and may be a more sensitive indicator of developmental disorders involving cerebellar dysfunction.

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“…CR latencies were also earlier to the light CS. Adult (PD70) females often outperformed their male counterparts, also consistent with our previous findings (Brown et al, 2008). …”

Section: Resultssupporting

confidence: 92%

Section: Resultssupporting

confidence: 92%

Section: Resultssupporting

confidence: 90%

“…Data analysis was similar to that described in previous studies (Brown et al 2008, 2006). EMG signals were sampled in 3.5 ms bins during the 1400 ms epoch of each trial type.…”

Section: Methodsmentioning

confidence: 78%