Dose-dependent benefit of nitroglycerin on microcirculation of patients with severe heart failure

Uil, Corstiaan A. den; Çalışkan, Kadir; Lagrand, Wim K.; Ent, Martin van der; Jewbali, Lucia S.D.; Kuijk, J.P. van; Spronk, Peter E.; Simoons, Maarten L.

doi:10.1007/s00134-009-1591-4

Cited by 80 publications

(43 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These findings were later confirmed by other groups of investigators [107][108][109][110]. More severe alterations were observed in patients with higher lactate levels [110] and poor outcome [55].…”

Section: Cardiogenic Shocksupporting

confidence: 77%

See 1 more Smart Citation

Monitoring the microcirculation in the critically ill patient: current methods and future approaches

et al. 2010

View full text Add to dashboard Cite

show abstract

Section: Cardiogenic Shocksupporting

confidence: 77%

“…More severe alterations were observed in patients with higher lactate levels [110] and poor outcome [55]. These alterations could be improved by nitroglycerin [107,108] or mechanical support such as aortic counterpulsation [109,111] or ventricular assist devices [112].…”

Section: Cardiogenic Shockmentioning

confidence: 99%

Monitoring the microcirculation in the critically ill patient: current methods and future approaches

et al. 2010

View full text Add to dashboard Cite

show abstract

“…These studies demonstrated an improvement in gastric perfusion suggesting that successful microcirculatory recruitment had occurred. More recently, studies have evaluated sublingual microcirculation during short-term infusions of nitroglycerin in septic or nonseptic shock and demonstrated significant improvements in microcirculation capillary density [29][30][31]. A randomized controlled trial in 70 patients with septic shock failed to show significant differences in the evolution of the sublingual microcirculation between the control and the protocol groups treated with a constant dose of nitroglycerin [30].…”

Section: Clinical Applications In Patient Managementmentioning

confidence: 99%

Clinical assessment of peripheral circulation

Lima

Bakker

2015

Current Opinion in Critical Care

View full text Add to dashboard Cite

The feasibility and reproducibility of the clinical assessment of peripheral circulation are substantial, and reliance on capillary refill time, skin temperature, and mottling score must be emphasized and exploited. Incorporating therapeutic strategies into resuscitation protocols that aim at normalizing these peripheral circulation parameters are being developed to investigate the impact of peripheral perfusion-targeted resuscitation in the survival of critically ill patients.

show abstract

“…Further studies evaluating measurements of microcirculation are necessary before a general recommendation for its routine use can be made. [7]. Darüber hinaus wurde auch die Anwendung von mechanischen "assist devices" evaluiert [24,25].…”

Section: Assessment Of Microcirculation In Critically Ill Patients Abunclassified

Beurteilung der Mikrozirkulation beim kritisch kranken Patienten

Jung

Kelm

Ferrari

2016

Med Klin Intensivmed Notfmed

View full text Add to dashboard Cite

Adequate organ supply of oxygen and of nutrients depends on microcirculation. Impaired microcirculation may result in temporary or irreversible loss of function. Therefore, critically ill patients require early diagnosis and therapy of microcirculatory disorders. Besides surrogate parameters of microcirculation like urine production or serum lactate levels, direct visualization became possible with sidestream darkfield intravital microscopy. This technique has been evaluated in clinical studies focusing on early diagnosis and therapy in cardiogenic shock like vasopressors, nitrates, or circulatory assist devices. Further studies evaluating measurements of microcirculation are necessary before a general recommendation for its routine use can be made.

show abstract

Dose-dependent benefit of nitroglycerin on microcirculation of patients with severe heart failure

Cited by 80 publications

References 33 publications

Monitoring the microcirculation in the critically ill patient: current methods and future approaches

Monitoring the microcirculation in the critically ill patient: current methods and future approaches

Clinical assessment of peripheral circulation

Beurteilung der Mikrozirkulation beim kritisch kranken Patienten

Contact Info

Product

Resources

About