“…The microbiota‐derived metabolites are one of the most important functional readouts of intestinal microbiota. Due to the taxonomic enrichment of Akkermansia , Alloprevotella , Parabacteroides , Alistipes , and Desulfovibrionaceae in the GbE group, we then performed targeted metabolomic analysis on SCFAs, indole derivatives and bile acids, which have previously been reported to be related to these bacteria (Hong et al, 2021; Wang et al, 2019; Wang, Tian, Yu, Wang, & Zhu, 2019; Yin et al, 2021; Zhou, Xiao, Zhang, Zheng, & Deng, 2019). From the heatmap of the SCFAs profiles, we observed that the WD feeding led to an overall reduction in serum SCFAs levels, especially decreased the concentrations of formic acid, butyric acid, valeric acid, and hexanoic acid (Figure 6a).…”