Dose-dependent antihypertensive determination and toxicological studies of tilianin isolated from Agastache mexicana

Hernández-Abreu, Oswaldo; Torres‐Piedra, Mariana; García‐Jiménez, Sara; Ibarra-Barajas, Maximiliano; Villalobos‐Molina, Rafael; Montes, Sergio; Rembao, Daniel; Estrada‐Soto, Samuel

doi:10.1016/j.jep.2012.12.029

Cited by 39 publications

(33 citation statements)

References 27 publications

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“…A hypotensive effect on both systolic and diastolic blood pressure was confirmed in vivo using a spontaneously hypertensive rat model in which the ED 50 was 53.51 mg/kg body weight (compared to captopril 30 mg/kg) (Hernandez-Abreu et al 2013). In the same study, no toxicity was found in the mouse model up to the dose of 1 g/kg, which warrants further investigation at the clinical level.…”

Section: Bioactivity Of Individual Species As Medicinal Plantsmentioning

confidence: 95%

“…Various extraction techniques were applied: maceration at ambient or elevated temperature, reflux extraction, infusions and decoctions in hot water. The extracts were usually dried under reduced pressure or by lyophilization (Itokawa et al 1981; Ganeva et al 1994; Lee et al 1995, 2002, 2007, 2008; Kim et al 1999; Molina-Hernandez et al 2000; Suvitayavat et al 2004; Vera-Montenegro et al 2008; Xu et al 2008; Hernandez-Abreu et al 2009, 2011, 2013; Gonzalez-Trujano et al 2012). …”

Section: Phytochemistrymentioning

confidence: 99%

“…One of the typical flavones reported in Agastache is an acacetin (5,7-dihydroxy-4′-methoxyflavone) glycoside—tilianin (acacetin-7-O-β-D-glucopyranoside) present in the aerial parts and roots of A. rugosa and A. mexicana (Itokawa et al 1981; Zou and Cong 1991; Tuan et al 2012; Hernandez-Abreu et al 2013). This compound appears to be more representative for A. mexicana than for A. rugosa .…”

Section: Phytochemistrymentioning

confidence: 99%

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Phytochemistry and bioactivity of aromatic and medicinal plants from the genus Agastache (Lamiaceae)

2014

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Agastache is a small genus of Lamiaceae, comprising 22 species of perennial aromatic medicinal herbs. In this article, we review recent advances in phytochemical, pharmacological, biotechnological and molecular research on Agastache. The phytochemical profile of all Agastache species studied to date is generally similar, consisted of two main metabolic classes—phenylpropanoids and terpenoids. In the relatively variable essential oils, most populations of different Agastache species contain over 50 % of a phenylallyl compound—estragole. Also, other volatile compounds (methyleugenol, pulegone, menthone, isomenthone and spathulenol) were reported in various proportions. Major non-volatile metabolites belong to phenolic compounds, such as caffeic acid derivatives, especially rosmarinic acid as well as several flavones and flavone glycosides like acacetin, tilianin, agastachoside, and a rare dimeric malonyl flavone (agastachin). Two unique lignans—agastenol and agastinol—were also isolated. Terpenoids include triterpenoids of oleanane-type (maslinic acid, oleanolic acid and β-amyrin), ursane-type (ursolic acid, corosolic acid and α-amyrin), and typical plant sterols, as well as abietane-type oxidized diterpenes (e.g., agastaquinone, agastol, and others). The bioactivity of various extracts or individual compounds in vitro and in vivo include antimicrobial, antiviral and anti-mutagenic activity, cytotoxic activity to cancer cell lines, and anti-nociceptive, anti-inflammatory, anti-atherogenic, antioxidant as well as biocidal activity to several foodstuff pests. Biotechnological and molecular studies have focused on in vitro propagation and enhancing the biosynthesis of bioactive metabolites in cell or organ cultures, as well as on the expression of genes involved in phenolic biosynthesis.

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Section: Bioactivity Of Individual Species As Medicinal Plantsmentioning

confidence: 95%

Section: Phytochemistrymentioning

confidence: 99%

Section: Phytochemistrymentioning

confidence: 99%

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Phytochemistry and bioactivity of aromatic and medicinal plants from the genus Agastache (Lamiaceae)

2014

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“…The Mexican endemic Agastache mexicana (Lamiacea) is an aromatic medicinal herb used in traditional medicine as a tranquilizer, sleep inducer, anti-hypertensive, rheumatism treatment, and treatment for stomach pain (Estrada-Reyes et al, 2014;Linares et al, 1995;Hernández-Abreu et al, 2013;Verano et al, 2013;Gonzalezhttp://dx.doi.org/10.1016Gonzalezhttp://dx.doi.org/10. /j.indcrop.2015.058 0926-6690/© 2015 Elsevier B.V. All rights reserved.…”

Section: Introductionmentioning

confidence: 99%

Antifungal activity of essential oils extracted from Agastache mexicana ssp. xolocotziana and Porophyllum linaria against post-harvest pathogens

Juárez

Hernández

Bach

et al. 2015

Industrial Crops and Products

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“…It can dispel damp, and relieve nausea and vomiting, and cure fungal infections. Pharmacological investigations have shown that A. rugosa have antiviral [1], antimicrobial [2], antioxidant [3], cardiovascular and anti-inflammatory [4, 5] activities, and some other activities [6]. …”

Section: Introductionmentioning

confidence: 99%

Analysis of tilianin and acacetin in Agastache rugosa by high-performance liquid chromatography with ionic liquids-ultrasound based extraction

Wei

Cao

Wang

2016

Chemistry Central Journal

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Ionic liquid 1-butyl-3-methylimidazolium bromide-methanol-based ultrasonic-assisted extraction (ILUAE) was used to extract tilianin and acacetin from the aerial parts of Agastache rugose (A. rugose), and simultaneously determined by reversed phase high performance liquid chromatographic (RP-HPLC) method with ultraviolet detection (RP-HPLC-UV). An InertSustain RP-C18 column was used with the mobile phase consisting of methanol and 0.2% acetic acid as gradient elution at the detection wavelength of 332 nm. The flow rate was 0.8 mL/min, and the column temperature was 30 °C. Under the optimized conditions, tilianin and acacetin displayed good linearity in the ranges of 0.0595–4.76 and 0.0585–4.68 μg/mL, respectively, with the average recoveries being 96.93 and 97.88%, respectively. The method of ILUAE was compared with the traditional methods, it exhibited higher efficiency, higher reproducibility and environmental friendly in analyzing the active compounds in traditional Chinese medicines (TCMs).

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Dose-dependent antihypertensive determination and toxicological studies of tilianin isolated from Agastache mexicana

Cited by 39 publications

References 27 publications

Phytochemistry and bioactivity of aromatic and medicinal plants from the genus Agastache (Lamiaceae)

Phytochemistry and bioactivity of aromatic and medicinal plants from the genus Agastache (Lamiaceae)

Antifungal activity of essential oils extracted from Agastache mexicana ssp. xolocotziana and Porophyllum linaria against post-harvest pathogens

Analysis of tilianin and acacetin in Agastache rugosa by high-performance liquid chromatography with ionic liquids-ultrasound based extraction

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