Dose-dependent absorption and excretion of vitamin C in humans

Melethil, Srikumaran; Mason, William D.; Chian-Jo, Chang

doi:10.1016/0378-5173(86)90216-4

Cited by 46 publications

(24 citation statements)

References 14 publications

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“…The peak serum level of vitamin C occurs at about four hours after administration. 23,24 In our study, the decrease in morphine consumption started post PACU discharge, approximately four hours after administration of vitamin C, which may correspond with the onset of its analgesic effect.…”

Section: Discussionsupporting

confidence: 51%

Effect of vitamin C on morphine use after laparoscopic cholecystectomy: a randomized controlled trial

Kanazi

El-Khatib

Yazbeck‐Karam

et al. 2012

Can J Anesth/J Can Anesth

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Section: Discussionsupporting

confidence: 51%

Effect of vitamin C on morphine use after laparoscopic cholecystectomy: a randomized controlled trial

Kanazi

El-Khatib

Yazbeck‐Karam

et al. 2012

Can J Anesth/J Can Anesth

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“…Using radiolabelled [l4C]ascorbic acid, Hornig et al [7] could show that with single doses of 1, 2, 3, 4, and 5 g the propor tion of urinary ascorbic acid excretion de creased from 75% at 1 g to 20% at 5 g. Other authors [9] found the relative absorption ca pacity to decrease from about 50% at intakes of 1.5 gto 16% at intakes of 12 g vitamin C. A study using divided doses [10] demonstrated that recovery of urinary ascorbic acid de creased from 57% at 2 x 500 mg vitamin C/ day to 19% at 3 x 2,000 mg/day. According to a study performed by Melethil et al [11], the renal clearance of ascorbic acid is directly dependent on the plasma concentration. At low levels, the dependence was not significant because of almost complete tubular reabsorp tion.…”

Section: Kinetics and Metabolism Of Vitamin C In Humansmentioning

confidence: 99%

No Contribution of Ascorbic Acid to Renal Calcium Oxalate Stones

Gerster¹

1997

Ann Nutr Metab

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Even though a certain part of oxalate in the urine derives from metabolized ascorbic acid (AA), the intake of high doses of vitamin C does not increase the risk of calcium oxalate kidney stones due to physiological regulatory factor: gastrointestinal absorption as well as renal tubular reabsorption of AA are saturable processes, and the metabolic transformation of AA to oxalate is limited as well. Older assays for urinary oxalate favored in vitro conversion of AA to oxalate during storage and processing of the samples. Recurrent stone formers and patients with renal failure who have a defect in AA or oxalate metabolism should restrict daily vitamin C intakes to -100 mg. But in the large-scale Harvard Prospective Health Professional Follow-Up Study, those groups in the highest quintile of vitamin C intake (> 1,500 mg/day) had a lower risk of kidney stones than the groups in the lowest quintiles.

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“…For vitamin C, however, the information is unavailable, incomplete, or flawed (3)(4)(5)(6)(7)(8)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) Assays and Data Calculation. Samples for vitamin C were analyzed by HPLC with coulometric electrochemical detection as described (27,28).…”

mentioning

confidence: 99%

Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance.

Levine

Conry‐Cantilena

Wang

et al. 1996

Proc. Natl. Acad. Sci. U.S.A.

1,139

1,026

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Determinants of the recommended dietary allowance (RDA) for vitamin C include the relationship between vitamin C dose and steady-state plasma concentration, bioavailability, urinary excretion, cell concentration, and potential adverse effects. Because current data are inadequate, an in-hospital depletion-repletion study was conducted. Seven healthy volunteers were hospitalized for 4-6 months and consumed a diet containing <5 mg of vitamin C daily. Steady-state plasma and tissue concentrations were determined at seven daily doses of vitamin C from 30 to 2500 mg. Vitamin C steady-state plasma concentrations as a function of dose displayed sigmoid kinetics. The steep portion of the curve occurred between the 30-and 100-mg daily dose, the current RDA of 60 mg daily was on the lower third of the curve, the first dose beyond the sigmoid portion of the curve was 200 mg daily, and complete plasma saturation occurred at 1000 mg daily. Neutrophils, monocytes, and lymphocytes saturated at 100 mg daily and contained concentrations at least 14-fold higher than plasma. Bioavailability was complete for 200 mg of vitamin C as a single dose. No vitamin C was excreted in urine of six of seven volunteers until the 100-mg dose. At single doses of 500 mg and higher, bioavailability declined and the absorbed amount was excreted. Oxalate and urate excretion were elevated at 1000 mg of vitamin C daily compared to lower doses. Based on these data and Institute of Medicine criteria, the current RDA of 60 mg daily should be increased to 200 mg daily, which can be obtained from fruits and vegetables. Safe doses of vitamin C are less than 1000 mg daily, and vitamin C daily doses above 400 mg have no evident value.The recommended dietary allowance (RDA) for vitamin C is 60 mg daily, based on threshold urinary excretion of the vitamin and on preventing the vitamin C deficiency disease scurvy with a margin of safety (1, 2).. Ingestion of 60 mg daily was proposed to prevent scurvy for 30-45 days if vitamin C intake ceased (1-7). Threshold urinary excretion of vitamin C was reported at the 60-mg daily dose (3,4,7,8 tTo whom reprint requests should be addressed.

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Dose-dependent absorption and excretion of vitamin C in humans

Cited by 46 publications

References 14 publications

Effect of vitamin C on morphine use after laparoscopic cholecystectomy: a randomized controlled trial

Effect of vitamin C on morphine use after laparoscopic cholecystectomy: a randomized controlled trial

No Contribution of Ascorbic Acid to Renal Calcium Oxalate Stones

Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance.

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