Dose Dependency of Aminophylline Effects on Hemodynamic and Ventricular Function in Patients With Chronic Obstructive Pulmonary Disease

Mols, Pierre; Huynh, Chi Hoang; Dechamps, Philippe; Naeije, Nicole; Ham, Hamphrey

doi:10.1378/chest.103.6.1725

Cited by 6 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Given the associated improvements in pulmonary artery occlusion pressure with these medications, PA pressure was likely reduced through improvements in lung mechanics. Oral theophylline has been associated with improved PA pressure, PVR, and cardiac index in COPD patients 82 , though these effects are strongly dependent on blood levels, even within the therapeutic range 83 . Theophylline is used infrequently in COPD patients due to the narrow therapeutic window, and drug clearance may be reduced in patients with diminished cardiac output.…”

Section: Therapeutic Optionsmentioning

confidence: 99%

Right Ventricular Dysfunction in Chronic Lung Disease

Kolb

Hassoun

2012

Cardiology Clinics

View full text Add to dashboard Cite

Right ventricular dysfunction arises in chronic lung disease when chronic hypoxemia and disruption of pulmonary vascular beds contribute to increase ventricular afterload, and is generally defined by hypertrophy with preserved myocardial contractility and cardiac output. Although the exact prevalence is unknown, right ventricular hypertrophy appears to be a common complication of chronic lung disease, and more frequently complicates advanced lung disease. Right ventricular failure is rare, except during acute exacerbations of chronic lung disease or when multiple co-morbidities are present. Treatment is targeted at correcting hypoxia and improving pulmonary gas exchange and mechanics. There are presently no convincing data to support the use of pulmonary hypertension-specific therapies in patients with right ventricular dysfunction secondary to chronic lung disease.

show abstract

Section: Therapeutic Optionsmentioning

confidence: 99%

Right Ventricular Dysfunction in Chronic Lung Disease

Kolb

Hassoun

2012

Cardiology Clinics

View full text Add to dashboard Cite

show abstract

“…In a study of patients with chronic obstructive pulmonary disease, Mols et al (1993) reported dose-dependency in the haemodynamic effects of aminophylline, with systemic and pulmonary vasodilatation occurring only at high doses. Our observations support this finding, the amplitude of changes in haemodynamic values increasing with dosage.…”

Section: Discussionmentioning

confidence: 99%

“…It has been used to decrease pulmonary arterial pressure and increase cardiac performance in chronic pulmonary hypertension (Maskin et al 1984;Matthay 1985;Panuccio et al 1984). Several studies have shown aminophylline to be an effective reducer of pulmonary pressures (Matthay et al 1978;Panuccio et al 1984;Parker et al 1966aParker et al & 1966b, while some more recent studies have questioned this finding (Mols et al 1993). Although other more specific phosphodiesterase inhibitors are available (i.e.…”

mentioning

confidence: 99%

The Effect of Aminophylline on Right Heart Function in Young Pigs after Ligation of the Right Coronary Artery

Spalding¹,

Ala‐Kokko²,

Kiviluoma³

et al. 2000

Pharmacology & Toxicology

View full text Add to dashboard Cite

An experimental model of right heart failure was developed to determine the effects of fluid loading and aminophylline on right heart function. We hypothesised that aminophylline would specifically improve right heart function through a decrease in pulmonary vascular resistance and, possibly, an increase in cardiac contractility. Right heart infarct was induced in ten experimental pigs and seven control pigs by ligating branches of the right coronary artery. The effect of fluid loading with a colloid solution and subsequent bolus doses of aminophylline on haemodynamics was observed. Fluid loading improved haemodynamics as expected. Aminophylline transiently improved cardiac index and pulmonary vascular resistance, but simultaneously caused an increase in heart rate and a decrease in stroke volume. Although aminophylline may reduce right heart afterload, it did not improve overall cardiac function in this experimental model of right heart infarction.

show abstract

“…Short-acting b-agonists and inhaled anticholinergics modestly reduce PA pressures during exercise in COPD patients, apparently by improving respiratory mechanics and lowering cardiac filling pressures (Saito et al 1999). Oral theophylline has been associated with improved PA pressure, PVR, and cardiac index in COPD patients (Matthay 1987), though these effects are strongly dependent on blood levels, even within the therapeutic range (Mols et al 1993). Theophylline is used infrequently in COPD patients due to the narrow therapeutic window, and drug clearance may be reduced in patients with diminished cardiac output.…”

Section: Obstructive Lung Diseasementioning

confidence: 99%

Pulmonary Hypertension Associated with Respiratory Diseases

Kolb

Hassoun

2014

PanVascular Medicine

View full text Add to dashboard Cite

Pulmonary hypertension is a common complication of many chronic respiratory diseases. The mechanisms contributing to the development of pulmonary hypertension in this context are multiple and go beyond chronic hypoxic vasoconstriction. Outcomes are universally worsened when pulmonary hypertension complicates chronic respiratory disease. Treatment strategies target the underlying disease, as pulmonary vasodilator therapy has proven largely ineffective in trials to date. This chapter summarizes current understanding of the epidemiology, pathophysiology, and treatment of pulmonary hypertension as it relates to a spectrum of chronic respiratory diseases.

show abstract

Dose Dependency of Aminophylline Effects on Hemodynamic and Ventricular Function in Patients With Chronic Obstructive Pulmonary Disease

Cited by 6 publications

References 23 publications

Right Ventricular Dysfunction in Chronic Lung Disease

Right Ventricular Dysfunction in Chronic Lung Disease

The Effect of Aminophylline on Right Heart Function in Young Pigs after Ligation of the Right Coronary Artery

Pulmonary Hypertension Associated with Respiratory Diseases

Contact Info

Product

Resources

About