Dose de tolérance des tissus sains : la thyroïde

Bergès, O.; Belkacémi, Yazid; Giraud, P.

doi:10.1016/j.canrad.2010.03.005

Cited by 17 publications

(3 citation statements)

References 38 publications

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“…The highest occurrence was around 24 months with an incidence rate of 28.6%. Such incidence was similar to some previous reports [ 18 , 19 ]. whereas a similar study by Fujiwara et al [ 20 ] on head and neck cancers reported a peak incidence of 36.4% at 24 months (median follow up period).…”

Section: Discussionsupporting

confidence: 93%

“…This was reflected by the significantly higher mean thyroid D mean and D 50 of over 5 Gy in the hypothyroidism patients compared with the non-hypothyroidism group. Echoed with the comment made by Berges et al [ 19 ] which stated that the onset of hypothyroidism depends on the total dose delivered to the gland and the irradiated volume, keeping a reasonably low mean thyroid dose in radiotherapy planning could reduce the risk of thyroid complication. Since our study revealed that over 80% of the hypothyroidism patients received mean thyroid dose of over 43 Gy, this could serve as a reference for setting the tolerance dose of this organ in treatment planning.…”

Section: Discussionmentioning

confidence: 96%

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Pattern of radiation-induced thyroid gland changes in nasopharyngeal carcinoma patients in 48 months after radiotherapy

Lin

et al. 2018

PLoS ONE

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ObjectivesRadiation-induced hypothyroidism is the most common thyroid disorder after radiotherapy in nasopharyngeal carcinoma (NPC) patients. This study evaluated the pattern of radiation-induced thyroid gland changes in 48 months after radiotherapy in NPC patients and the association of hypothyroidism incidence with thyroid dose.MethodsFifty-six NPC patients treated by intensity modulated radiotherapy in 2013 were recruited. All patients received baseline thyroid hormones (fT3, fT4 and TSH) tests and CT scan before radiotherapy. Repeated measures of the thyroid hormones and gland volume were performed at 3, 6, 12, 18, 24, 30, 36 and 48 months after treatment. Trend lines of the thyroid volume and hormone level changes against time were plotted. The incidence of hypothyroidism patients and its relationship with the dose were also evaluated.ResultsThe mean thyroid volume followed a decreasing trend after radiotherapy, reaching a minimum (-39.8%) at 30 months and slightly increased afterward. The fT4 level followed a similar pattern with its mean value dropped by 21.5% at 30 months and became steady after 36 months. TSH level showed gradual rise from just after radiotherapy, reaching a peak at 24 months and became relatively steady after 36 months. The incidence of hypothyroidism increased to a maximum at 24 months (28.6%) and dropped afterwards. Thyroid Dmean and D50 were significantly correlated with hypothyroidism incidence in 12 to 30 months (ρ > 0.40, p < 0.05).ConclusionThe patterns of radiation induced thyroid volume shrinkage and fT4 level reduction were similar, with both of them showed decreasing trend from 0 to 30 months. The thyroid volume and function reached a relatively steady state after 36 months. The incidence of hypothyroidism increased up to 24 months and its frequency was associated with the thyroid dose.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 96%

Pattern of radiation-induced thyroid gland changes in nasopharyngeal carcinoma patients in 48 months after radiotherapy

Lin

et al. 2018

PLoS ONE

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“…Further studies are needed, with larger series, in order to clarify, using FISH technique, the actual importance of these rearrangements when the thyroid is submitted to lowdose external radiation. This is important if we take into account that radiotherapy for head and neck cancers, thorax cancers, lymphomas, breast cancers and even all body irradiation may expose the thyroid to radiation due to its anatomical position (44).…”

Section: Discussionmentioning

confidence: 99%

Genetic alterations in thyroid tumors from patients irradiated in childhood for tinea capitis treatment

Boaventura

Pereira

Celestino

et al. 2013

European Journal of Endocrinology

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Objective: Exposure to ionizing radiation at young age is the strongest risk factor for the occurrence of papillary thyroid carcinoma (PTC). RET/PTC rearrangements are the most frequent genetic alterations associated with radiation-induced PTC, whereas BRAF and RAS mutations and PAX8-PPARG rearrangement have been associated with sporadic PTC. We decided to search for such genetic alterations in PTCs of patients subjected in childhood to scalp irradiation. Design: We studied 67 thyroid tumors from 49 individuals irradiated in childhood for tinea capitis scalp epilation: 36 malignant (12 cases of conventional PTC (cPTC), two cPTC metastases, 20 cases of follicular variant PTC (FVPTC), one oncocytic variant of PTC and one follicular carcinoma) and 31 follicular thyroid adenomas. Methods: The lesions were screened for the BRAF V600E and NRAS mutations and for RET/PTC and PAX8-PPARG rearrangements. Results: BRAF V600E mutation was detected in seven of 14 (50%) cPTC and two of 20 FVPTC (10%) (PZ0.019). NRAS mutation was present in one case of FVPTC (5%). RET/PTC1 rearrangement was found, by RT-PCR, in one of 17 cases (5.9%) and by fluorescence in situ hybridization in two of six cases (33%). PAX8-PPARG rearrangement was not detected in any carcinoma. None of the follicular adenomas presented any of the aforementioned genetic alterations. Conclusions: The prevalence of BRAF V600E mutation in our series is the highest reported in series of PTCs arising in radiation-exposed individuals. The prevalence of RET/PTC1 rearrangement fits with the values recently described in a similar setting.

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Neuroendocrine Complications of Radiation and Cancer Therapy

Merchant

Rose

2013

ALERT • Adverse Late Effects of Cancer Treatment

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Dose de tolérance des tissus sains : la thyroïde

Cited by 17 publications

References 38 publications

Pattern of radiation-induced thyroid gland changes in nasopharyngeal carcinoma patients in 48 months after radiotherapy

Pattern of radiation-induced thyroid gland changes in nasopharyngeal carcinoma patients in 48 months after radiotherapy

Genetic alterations in thyroid tumors from patients irradiated in childhood for tinea capitis treatment

Neuroendocrine Complications of Radiation and Cancer Therapy

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