Dose-current discharge correlation analysis in a Mather type Plasma Focus device for medical applications

Sumini, Marco; Mostacci, Domiziano; Tartari, A.; Mazza, A.; Cucchi, G.; Isolan, Lorenzo; Buontempo, Francesca; Zironi, Isabella; Castellani, Gastone

doi:10.1016/j.radphyschem.2017.03.022

Cited by 6 publications

(3 citation statements)

References 11 publications

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“…PFMA-3 has been geared as a pulsed X-rays generator. The low-energy (up to 200 keV) X-rays produced by conversion on a brass target of the self-collimated electron beam generated by the device during the pinch phase are able to deliver a very high DR as shown in Table 1 where the main PFMA-3 features are summarized [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Enhancing radiosensitivity of melanoma cells through very high dose rate pulses released by a plasma focus device

et al. 2018

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Radiation therapy is a useful and standard tumor treatment strategy. Despite recent advances in delivery of ionizing radiation, survival rates for some cancer patients are still low because of recurrence and radioresistance. This is why many novel approaches have been explored to improve radiotherapy outcome. Some strategies are focused on enhancement of accuracy in ionizing radiation delivery and on the generation of greater radiation beams, for example with a higher dose rate. In the present study we proposed an in vitro research of the biological effects of very high dose rate beam on SK-Mel28 and A375, two radioresistant human melanoma cell lines. The beam was delivered by a pulsed plasma device, a “Mather type” Plasma Focus for medical applications. We hypothesized that this pulsed X-rays generator is significantly more effective to impair melanoma cells survival compared to conventional X-ray tube. Very high dose rate treatments were able to reduce clonogenic efficiency of SK-Mel28 and A375 more than the X-ray tube and to induce a greater, less easy-to-repair DNA double-strand breaks. Very little is known about biological consequences of such dose rate. Our characterization is preliminary but is the first step toward future clinical considerations.

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Section: Introductionmentioning

confidence: 99%

Enhancing radiosensitivity of melanoma cells through very high dose rate pulses released by a plasma focus device

et al. 2018

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“…Plasma focus (PF) devices are investigated as intense soft x-ray (SXR) sources for their potential use in industrial applications such as medical applications [1][2][3][4][5][6], micro-machining [7,8], and lithography [9][10][11]. Therefore, the interest in the PF devices is growing in order to produce x-rays from these devices operated with various gases such as neon (Ne) and nitrogen (N).…”

Section: Introductionmentioning

confidence: 99%

Spherical plasma focus operated with nitrogen and neon gases for soft x-rays (bremsstrahlung radiation, line radiation, and radiative recombination)

2021

Plasma Phys. Control. Fusion

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X-ray emissions (bremsstrahlung radiation, line radiation, and radiative recombination) from spherical plasma focus (SPF) device are investigated with the developed spherical MHD model for nitrogen (N) and neon (Ne) gases with respect to gas pressure, which is varied from 0.1 Torr to 7 Torr. Ion density, plasma velocity, pinch temperature, and peak current are also calculated for N and Ne gases. The total capacitance, external inductance, charging voltage, and stored energy as the operational conditions of the SPF device in this study are 432 µF, 36 nH, 25 kV, and 135 kJ. The maximum current is achieved at 7 Torr for both N (1561 kA) and Ne (1525 kA). It is found that there is an optimum pressure point for both x-rays (bremsstrahlung radiation, line radiation, and radiative recombination) and the used gases (N and Ne), separately. While the optimum pressure of bremsstrahlung radiation for N and Ne gases are 0.9 Torr and 1 Torr, respectively, these optimum pressures of radiative recombination and line radiation are 1 Torr for N gas and 1.1 Torr for Ne gas, respectively. It is also found that line radiation constitutes the big portion of the soft x-ray (SXR) emissions from SPF device. Line radiations of N at 1 Torr and Ne at 1.1 Torr are 911 J (91% of total N SXRs) and 3036.5 J (93.1% of total Ne SXRs), respectively, which shows that SPF device can be considered as a good SXR source. Ion densities and peak currents at 7 Torr are calculated as 21.88 × 1023 m−3 with 1561 kA peak current for N gas and 15.98 × 1023 m−3 with 1525 kA peak current for Ne gas.

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“…of the University of Bologna to evaluate its possible uses in radiotherapy treatments thanks to the extremely high dose rate of up to 1 Gy/shots (each shots lasting 20-50 ns) that it is able to guarantee. To achieve this goal, the control, the analysis and the measurement of the delivered dose was performed as shown in Sumini et al (2017). The pre-clinical characterization of the effects of the very-high dose rate was analysed on in-vitro melanoma SK-MEL28 malignant cells cultures and the results compared with the ones coming from a traditional X-ray (XR) sources.…”

Section: Introductionmentioning

confidence: 99%

Dosimetric analysis and experimental setup design for in-vivo irradiation with a Plasma Focus device

Isolan

Sumini

Teodori

et al. 2019

Radiation Physics and Chemistry

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Dose-current discharge correlation analysis in a Mather type Plasma Focus device for medical applications

Cited by 6 publications

References 11 publications

Enhancing radiosensitivity of melanoma cells through very high dose rate pulses released by a plasma focus device

Enhancing radiosensitivity of melanoma cells through very high dose rate pulses released by a plasma focus device

Spherical plasma focus operated with nitrogen and neon gases for soft x-rays (bremsstrahlung radiation, line radiation, and radiative recombination)

Dosimetric analysis and experimental setup design for in-vivo irradiation with a Plasma Focus device

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