“…They stated a nonsignificant trend of blood transfusion requirement decrease in the treated group compared with the placebo group during surgery and the postoperative period. 23 A few studies 13,16,17,20,23 have shown that intraoperative TXA administration led to less blood loss compared with a placebo group for different types of surgery. Nevertheless, some researchers 19,22 did not report a significant difference in blood loss using TXA or aprotinin, despite a significant decrease in total blood transfusion in the treated patients.…”