Dose as a function of liver volume and planning target volume in helical tomotherapy, intensity-modulated radiation therapy–based stereotactic body radiation therapy for hepatic metastasis

Baisden, Joseph M.; Reish, Andrew G.; Sheng, Ke; Larner, James M.; Kavanagh, Brian D.; Read, Paul W.

doi:10.1016/j.ijrobp.2006.05.034

Cited by 23 publications

(11 citation statements)

References 24 publications

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“…Planning objectives were derived from the literature (6,9,21,22) and from our own clinical data. Compared with published constraints, our planning objectives for the stomach, duodenum and small bowel were adjusted for fraction dose (23,24).…”

Section: Patient Selection and Planning Objectivesmentioning

confidence: 99%

Critical Appraisal of Volumetric Modulated Arc Therapy in Stereotactic Body Radiation Therapy for Metastases to Abdominal Lymph Nodes

Bignardi

Cozzi

Fogliata

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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Section: Patient Selection and Planning Objectivesmentioning

confidence: 99%

Critical Appraisal of Volumetric Modulated Arc Therapy in Stereotactic Body Radiation Therapy for Metastases to Abdominal Lymph Nodes

Bignardi

Cozzi

Fogliata

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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“…HT liver SBRT delivers doses in an image-guided technique and can be a noninvasive and safe alternative treatment for unresectable HCC 11. The main pattern of hepatic toxicity after SBRT includes elevations in serum liver enzyme or bilirubin levels 12,13.…”

Section: Resultsmentioning

confidence: 99%

Recall radiation dermatitis by sorafenib following stereotactic body radiation therapy

Hsieh¹,

Lin²,

Shueng³

et al. 2014

OTT

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We report on a 63-year-old man with a history of hepatitis B virus–related hepatocellular carcinoma with a thrombus extending into the inferior vena cava, who received image-guided stereotactic body radiation therapy (SBRT) with helical tomotherapy, followed by sorafenib. A total tumor dose of 48 Gy was delivered by 6 fractions within 2 weeks. The tumor responded dramatically, and the patient tolerated the courses well. Ten days after SBRT, sorafenib (200 mg), at 1.5 tablets twice a day, was prescribed. One week later, grade 2 recall radiation dermatitis subsequently developed in the previous SBRT off-target area. SBRT followed by sorafenib for the treatment of a portal vein thrombosis provided effective results, but the potential risk of enhanced adverse effects between radiation and sorafenib should be considered with caution, especially under a SBRT scheme.

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“…In an earlier study to provide guidelines to treatment planning, a predictive model was developed to calculate the maximum tolerable dose for Helical TomoTherapy-based SBRT [10]. The model provided a crude estimate for the achievable target dose based on the liver and PTV volume but it did not consider the relative position of the PTV to the liver and was unable to predict the liver dose volume for a given prescription.…”

Section: Introductionmentioning

confidence: 99%

Predicting liver SBRT eligibility and plan quality for VMAT and 4π plans

et al. 2017

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BackgroundIt is useful to predict planned dosimetry and determine the eligibility of a liver cancer patient for SBRT treatment using knowledge based planning (KBP). We compare the predictive accuracy using the overlap volume histogram (OVH) and statistical voxel dose learning (SVDL) KBP prediction models for coplanar VMAT to non-coplanar 4π radiotherapy plans.MethodsIn this study, 21 liver SBRT cases were selected, which were initially treated using coplanar VMAT plans. They were then re-planned using 4π IMRT plans with 20 inversely optimized non-coplanar beams. OVH was calculated by expanding the planning target volume (PTV) and then plotting the percent overlap volume v with the liver vs. r v, the expansion distance. SVDL calculated the distance to the PTV for all liver voxels and bins the voxels of the same distance. Their dose information is approximated by either taking the median or using a skew-normal or non-parametric fit, which was then applied to voxels of unknown dose for each patient in a leave-one-out test. The liver volume receiving less than 15 Gy (V<15Gy), DVHs, and 3D dose distributions were predicted and compared between the prediction models and planning methods.ResultsOn average, V<15Gy was predicted within 5%. SVDL was more accurate than OVH and able to predict DVH and 3D dose distributions. Median SVDL yielded predictive errors similar or lower than the fitting methods and is more computationally efficient. Prediction of the 4π dose was more accurate compared to VMAT for all prediction methods, with significant (p < 0.05) results except for OVH predicting liver V<15Gy (p = 0.063).ConclusionsIn addition to evaluating plan quality, KBP is useful to automatically determine the patient eligibility for liver SBRT and quantify the dosimetric gains from non-coplanar 4π plans. The two here analyzed dose prediction methods performed more accurately for the 4π plans than VMAT.

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Dose as a function of liver volume and planning target volume in helical tomotherapy, intensity-modulated radiation therapy–based stereotactic body radiation therapy for hepatic metastasis

Cited by 23 publications

References 24 publications

Critical Appraisal of Volumetric Modulated Arc Therapy in Stereotactic Body Radiation Therapy for Metastases to Abdominal Lymph Nodes

Critical Appraisal of Volumetric Modulated Arc Therapy in Stereotactic Body Radiation Therapy for Metastases to Abdominal Lymph Nodes

Recall radiation dermatitis by sorafenib following stereotactic body radiation therapy

Predicting liver SBRT eligibility and plan quality for VMAT and 4π plans

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