Dose- and time-related effects of caffeine on the testis in immature male rats

Bae, Jaeman; Choi, Hyeonhae; Choi, Yuri; Roh, Jaesook

doi:10.1538/expanim.16-0060

Cited by 12 publications

(19 citation statements)

References 28 publications

(43 reference statements)

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“…Likewise, prepubertal exposure to caffeine reduces both the weight of the testes and the size of the seminiferous tubules in immature animals (9,24). Consistent with these previous reports, we observed that caffeine causes a significant decrease in testicular weight in a dose-dependent manner in immature rats (Fig.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Caffeine on the Long Bones and Testes in Immature and Young Adult Rats

2017

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This study was to evaluate the age-dependent effects of caffeine exposure on the long bones and reproductive organs using male rats. A total of 15 immature male rats and 15 young adult male rats were allocated randomly to three groups: a control group and two groups fed caffeine with 120 and 180 mg/kg/day for 4 weeks. Exposure to caffeine at either dose significantly reduced body weight gain; a proportional reduction in muscle and fat mass in immature animals, whereas a selective reduction in fat mass with relatively preserved muscle mass in young adult animals. The long bones of immature rats exposed to caffeine were significantly shorter and lighter than those of control animals along with decreased bone minerals. However, there was no difference in the length or weight of the long bones in young adult rats exposed to caffeine. Exposure to caffeine reduced the size and absolute weight of the testes significantly in immature animals in comparison to control animals, but not in young adult animals exposed to caffeine. In contrast, the adrenal glands were significantly heavier in caffeine-fed young adult rats in comparison to control animals, but not in caffeine-fed immature rats. Our results clearly show that the negative effects of caffeine on the long bones and testes in rats are different according to the age of the rat at the time of exposure, and might therefore be caused by changes to organ sensitivity and metabolic rate at different developmental stages. Although the long bones and testes are more susceptible to caffeine during puberty, caffeine has negative effects on body fat, bone minerals and the adrenal glands when exposure occurs during young adulthood. There is a need, therefore, to educate the public the potential dangers of caffeine consumption during puberty and young adulthood.

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Section: Discussionmentioning

confidence: 99%

The Effects of Caffeine on the Long Bones and Testes in Immature and Young Adult Rats

2017

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“…Initiating on entry of the males and up to the day of birth, pregnant rats were administered ad libitum tap water (group N of mothers, control, n=10) or caffeine-enriched water (group C of mothers, n=10), in a concentration estimated to equal a daily caffeine uptake of 20 mg/kg of body weight. The selected dose was comparable to that of the human consumption of approximately two cups of coffee [15,16].…”

Section: Experimental Designmentioning

confidence: 93%

Metabolic Response of Adult Male Offspring Rats to Prenatal Caffeine Exposure

Mastroleon

Κορού

Pergialiotis

et al. 2020

Cureus

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Caffeine is the most widely consumed psychoactive substance, with recommendations from health associations and regulatory bodies for limiting caffeine consumption during pregnancy being increasingly common. Prenatal exposure to caffeine has been shown to increase the risk of developing abnormalities in lipid metabolism in adult life. We further investigated the effect of prenatal caffeine exposure (PCE) (20 mg/kg of body weight) on the metabolic "reserve" of male Sprague Dawley offspring fed on a high fructose diet in adult life. Male adult PCE offspring were assigned to four groups; Nw and Nf: offspring of control mothers (N group of mothers), having received tap water or high fructose water respectively; Cw and Cf: offspring exposed to caffeine during gestation (C group of mothers) and receiving tap water or a high fructose water solution, respectively. Cf rats presented increased serum triglyceride level, as well as raised systolic and diastolic blood pressure levels, together with extensive renal tissue oedema in adulthood, compared to the other groups (p<0.05 for all comparisons). These findings show further evidence for potential detrimental metabolic effects of prenatal caffeine exposure during adulthood in this animal model.

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“…Caffeine has also been associated with lower levels of oestrogen in offspring, which is suggested to affect Sertoli cell maturation in foetal life (Ramlau-Hansen et al, 2008). Caffeine exposure in peripubertal rats decreases testosterone production and delays the onset of maturation, with a subsequent decrease in seminiferous tubule diameter and epithelial cell height (Bae, Choi, Choi, & Roh, 2016). Park, Choi, Choi, Yim, and Roh (2015) found similar outcomes in peripubertal rats through prenatal caffeine exposure.…”

Section: Caffeine Consumptionmentioning

confidence: 94%

Do lifestyle practices impede male fertility?

Leisegang

Dutta

2020

Andrologia

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Infertility is defined as the inability to achieve conception after 12 months of regular (>3 times per week) sexual intercourse without contraception (WHO, 2010). Approximately 15% of couples globally are infertile, with up to half of these due to male factor infertility. Male infertility is considered the primary cause of infertility in 20% of couples and a contributory factor in 30%-40% of cases (Esteves,

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Dose- and time-related effects of caffeine on the testis in immature male rats

Cited by 12 publications

References 28 publications

The Effects of Caffeine on the Long Bones and Testes in Immature and Young Adult Rats

The Effects of Caffeine on the Long Bones and Testes in Immature and Young Adult Rats

Metabolic Response of Adult Male Offspring Rats to Prenatal Caffeine Exposure

Do lifestyle practices impede male fertility?

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