Dose and time-dependent effects of sodium fluoride on sperm motility: An in vitro study

Chaithra, B; Sarjan, Halugudde Nagaraja; Shivabasavaiah,

doi:10.1177/0748233718795926

Cited by 9 publications

(5 citation statements)

References 16 publications

(21 reference statements)

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“…The present study for the first time revealed that the adverse effect of ground water F on spermatozoa is dependent on duration of exposure. There was a time-dependent decrease in motility and activities of antioxidant enzymes and increase in abnormality and lipid peroxidation of spermatozoa due to treatment of ground water F. These results were similar to our previous study where treatment of NaF caused time-dependent depletion of motility of spermatozoa in in vitro (Chaithra et al, 2018). The present investigation involved two different in vitro experiments where spermatozoa were treated with ground water F at 0, 15, and 30 min time intervals.…”

Section: Discussionsupporting

confidence: 91%

Time-dependent effect of ground water fluoride on motility, abnormality and antioxidant status of spermatozoa: Anin vitrostudy

2019

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The present study was undertaken to investigate the toxic effect of ground water fluoride (F) on motility, abnormality, and antioxidant status of spermatozoa. Treatment of ground water F with epididymal sperm suspension caused complete loss of sperm motility and decrease in the activities of superoxide dismutase (SOD) and catalase (CAT) and increase in the concentration of malondialdehyde (MDA) and abnormality of spermatozoa at 15 and 30 min time intervals. Further, incubation of spermatozoa with ground water F for 5, 10, and 15 min time intervals significantly reduced the sperm motility and activities of SOD and CAT and increased the concentration of MDA and abnormality of spermatozoa. The study revealed that F-induced effect on sperm motility and antioxidant status is time dependent. Increase in oxidative stress and concomitant decrease in motility of spermatozoa in ground water F clearly indicates that F-induced oxidative stress affected the sperm motility. The present study for the first time demonstrated the toxic effect of ground water F on spermatozoa at shorter duration of exposure, which affects the capability of spermatozoa in fertilization.

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Section: Discussionsupporting

confidence: 91%

Time-dependent effect of ground water fluoride on motility, abnormality and antioxidant status of spermatozoa: Anin vitrostudy

2019

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“…Fluoride is a common chemical element with an effect on male fertility that has attracted much attention. 23 Fluoride-induced reductions in T levels and sperm motility have been detected in male rats, as described in a literature review. 24 Fluoride-induced OS has been reported to cause impaired antioxidant defense systems, mitochondrial dysfunction, and genotoxicity in animal models, and antioxidant intervention might be affected by antioxidants.…”

Section: Discussionmentioning

confidence: 91%

Glutathione S-transferase genetic polymorphisms and fluoride-induced reproductive toxicity in men with idiopathic infertility

Liu

et al. 2022

Asian Journal of Andrology

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Male infertility caused by idiopathic oligoasthenospermia (OAT) is known as idiopathic male infertility. Glutathione S-transferase (GST) and fluoride may play important roles in idiopathic male infertility, but their effects are still unknown. Our study examined the relationship between GST polymorphisms and fluoride-induced toxicity in idiopathic male infertility and determined the underlying mechanism. Sperm, blood, and urine samples were collected from 560 males. Fluoride levels were measured by a highly selective electrode method, and GST genotypes were identified using polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (PCR-RFLP). Semen parameters, DNA fragmentation index (DFI), mitochondrial membrane potential (MMP), and oxidative stress (OS) biomarkers were statistically assessed at the P < 0.05 level. Compared with healthy fertile group, semen parameters, fluoride levels, OS biomarkers, sex hormone levels, and MMP and DFI levels were lower in the idiopathic male infertility group. For glutathione S-transferase M1 (GSTM1[-]) and glutathione S-transferase T1 (GSTT1[-]) or glutathione S-transferase P1 (GSTP1) mutant genotypes, levels of semen fluoride, OS, MMP, and DFI were considerably higher, and the mean levels of sperm parameters and testosterone were statistically significant in GSTM1(+), GSTT1(+), and GSTP1 wild-type genotypes. Both semen and blood fluoride levels were associated with oxidative stress in idiopathic male infertility patients. Elevated fluoride in semen with the genotypes listed above was linked to reproductive quality in idiopathic male infertility patients. In conclusion, GST polymorphisms and fluorine may have an indicative relationship between reproductive quality and sex hormone levels, and OS participates in the development of idiopathic male infertility.

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“…Regarding the consumption of one serving of any of the brands analyzed by children over 9 years of age and the adult population, it does not pose a health risk, but it is necessary to consider that the percentage of contribution is significant (31.0%) and that other dietary sources of fluoride could increase the global intake with a consequent risk to health, leading to the appearance of dental or bone fluorosis, especially in young children, and neurological, heart and fertility problems, among others [ 24 , 41 , 42 ]. In all cases, moderate consumption should be recommended, since in consumption scenarios of two to three servings, the value of the ADI is already exceeded or close to 100%, depending on the age group.…”

Section: Resultsmentioning

confidence: 99%

Fluoride Exposure from Soybean Beverage Consumption: A Toxic Risk Assessment

Mesa-Infante

Niebla-Canelo

Alejandro-Vega

et al. 2022

Foods

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The consumption of vegetable milk as a substitute for cow’s milk has increased in recent years. Of all the vegetable beverages on the market, soy is the most widely consumed. Soy is exposed to contamination by different chemical elements during harvesting. In this study, the concentration of fluoride in soy beverages was analyzed. Fluoride is an element that in high concentrations can be toxic, causing dental and bone fluorosis. The aims of the study were (i) to analyze the fluoride concentration in 30 samples in the most popular brands (A-Brand, B-Brand, C-Brand) of soybean beverages by a fluoride ion selective potentiometer and (ii) to evaluate the toxicological risk derived from its consumption. The fluoride concentrations were 15.5 mg/L (A-Brand), 11.3 mg/L (B-Brand) and 8.5 mg/L (C-Brand). A consumption of 1 to 3 servings/day was established. One serving (200 mL) of soybean beverage offered a contribution percentage over the ADI (acceptable daily intake) for infants and children. Teenagers and adults did not exceed the ADI (10 mg/day). The consumption of soy beverages contributes significantly to the daily intake of fluoride, which could exceed the ADI with a consequent health risk. It is recommended to control the fluoride levels in the raw material and in the final product to assure the safety of these products.

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Dose and time-dependent effects of sodium fluoride on sperm motility: An in vitro study

Cited by 9 publications

References 16 publications

Time-dependent effect of ground water fluoride on motility, abnormality and antioxidant status of spermatozoa: Anin vitrostudy

Time-dependent effect of ground water fluoride on motility, abnormality and antioxidant status of spermatozoa: Anin vitrostudy

Glutathione S-transferase genetic polymorphisms and fluoride-induced reproductive toxicity in men with idiopathic infertility

Fluoride Exposure from Soybean Beverage Consumption: A Toxic Risk Assessment

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