Dose- and Sex-Independent Disposition of Ciprofloxacin

Ciprofloxacin biliary disposition in cholecystectomised patients with special references to HPLC and bioassay data

“…14th International Congress of Chemotherapy, Kyoto, 1985, Abstract N°S-42-7). Some data are available on the oral pharmacokinetics of ciprofloxacin in the literature (8,9,II,13,14,15,16,20,24). Comparison of the present results with those published by other authors show some discrepancies on peak levels which are lower in our patients who were at the 8th post-operative day, compared with healthy volunteers.…”

“…This difference cannot be explained by capacity-limited kinetics as Hoffler et al (16) showed no dose-dependance of ciprofloxacin kinetic after increasing doses. As we saw above, Hoffken et al (15) found that the two main urinary metabolites are inactive, thus an eventual interference of any active metabolite in bioassay in unlikely to have occurred in the studies of Wise et al (9,26).…”

Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ciprofloxacin Hydrochloride

“…Since ciprofloxacin is a zwitterionic drug and is probably absorbed by passive diffusion, intestinal pH changes suggest that rapid absorption may occur in the duodenum and proximal jejunum, whereas absorption may decrease in the distal portion of the intestine. 41 Other authors, 42 using HPLC methodology, could not detect dose disproportionality in ciprofloxacin kinetics after a single oral administration of 100, 250, 500, or 1000 mg. Nonetheless, no other reports on dose proportionality problems could be identified.…”

“…Penetration in bile, prostatic tissue, gingival fluid, and lung tissue is higher than the concentration achieved in plasma. 42,[51][52][53][54] The values for the volumes of distribution have been reported to be 2.27 and 2.44 L/kg for doses of 100 and 200 mg, respectively. 55 Ciprofloxacin is cleared by both renal and nonrenal mechanisms.…”

“…77 '' With respect to the linearity of absorption: the data are somewhat conflicting. Some authors report a nonlinear increase of AUC, C max and/ or t max with dose [39][40][41][42] , other authors could not detect dose disproportionality in ciprofloxacin kinetics after a single oral administration.…”