Dose and Risk Characterization in CT

Kofler, Cameron; Olguin, Edmond A.; Abadia, Andres F.; Bolch, Wesley E.

doi:10.1007/978-3-030-26957-9_5

Cited by 1 publication

(5 citation statements)

References 20 publications

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“…Yield = 90%. 1 H NMR (300 MHz, CDCl 3 ) δ (ppm): 8.64 (2H, dd, J 1 = 12.0 Hz, J 2 = 3.0 Hz), 8.50 (1H, d, J = 6.0 Hz), 7.85 (2H, dd, J 1 = 15.0 Hz, J 2 = 6.0 Hz), 7.55 (1H, s), 7.02 (2H, d, 6 Hz), 4.23 (2H, t, J = 9.0 Hz), 4.08 (2H, t, J = 9.0 Hz), 2.27 (2H, quin, J = 6.0 Hz). 13 was dissolved in acetonitrile, and the corresponding alkyl bromide compound (n-octyl, n-decyl, or n-tetradecyl) was added to the solution and heated to reflux for 72 h (4 days for n-tetradecyl alkyl bromide).…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…mp = 70−73 °C. 1 H NMR (300 MHz, CDCl 3 ) δ (ppm): 10.56 (1H, s), 8.56 (2H, dd, J 1 = 15.0 Hz, J 2 = 6.0 Hz), 8.42 (1H, d, J = 6.0 Hz), 7.80 (2H, dd, J 1 = 9.0 Hz, J 2 = 6.0 Hz), 7.71 (1H, s), 7.39 (1H, s), 4.52 (2H, t, J = 6.0 Hz), 4.38 (2H, t, J = 6.0 Hz), 4.20 (2H, t, J = 6.0 Hz), 2.44 (2H, quin, J = 6.0 Hz), 1.95, (2H, m), 1. 27 1 H NMR (300 MHz, CDCl 3 ) δ (ppm): 10.52 (1H, s), 8.56 (2H, t, J = 9.0 Hz), 8.41 (1H, d, J = 9.0 Hz), 7.79 (3H, m), 7.44 (1H, s), 4.54 (2H, t, J = 6.5 Hz), 4.40 (2H, t, J = 6.5 Hz), 4.20 (2H, t, J = 6.5 Hz), 2.45 (2H, quin, J = 6.5 Hz), 1.92 (4H, m), 1.24 (14H, m), 0.86 (3H, t, J = 6.0 Hz).…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…33 [C 14 NIim][glu] is a pale orange waxy solid. 1 H NMR (300 MHz, DMSO) δ (ppm): 9.21 (1H, s), 8.61 (2H, dd, J 1 = 15 Hz, J 2 = 9 Hz), 8.43 (1H, d, J = 9 Hz), 8.03 (2H, m), 7.80 (2H, d, J = 9 Hz), 4.28 (2H, t, J = 6 Hz), 4.14 (2H, t, J = 6 Hz), 4.07 (2H, t, J = 6 Hz), 3.60 (1H, m), 3.40 (2H, m), 3.32 (8H, m), 3.23 (2H, t, J = 6 Hz), 1.77 (2H, m), 1.20 (22H, m), 0.83 (3H, t, J = 6 Hz). 13 Gelation Tests and T gel Determination.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…The increasing incidence of cancer worldwide has raised the use of diagnostic technologies and, at the same time, the need to identify alternative methods to existing imaging techniques. This is mainly due to the awareness that these technologies could increase cancer risks for patients, even if computed tomography is an indispensable medical treatment . On the other hand, it is well known that the most widely used diagnostic medical imaging technique, i.e.…”

Section: Introductionmentioning

confidence: 99%

“…This is mainly due to the awareness that these technologies could increase cancer risks for patients, even if computed tomography is an indispensable medical treatment. 1 On the other hand, it is well known that the most widely used diagnostic medical imaging technique, i.e., X-ray imaging, is the largest man-made source of radiation exposure to the general population. 2,3 Thus, the design of new efficient materials for bioimaging, which are less invasive and reduce exposure to radiation, is quite urgent.…”

Section: ■ Introductionmentioning

confidence: 99%

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Naphthalimide Imidazolium-Based Supramolecular Hydrogels as Bioimaging and Theranostic Soft Materials

Rizzo

Mattiello

Marullo

et al. 2020

ACS Appl. Mater. Interfaces

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1,8-Naphthalimide-based imidazolium salts differing for the alkyl chain length and the nature of the anion were synthesized and characterized to obtain fluorescent probes for bioimaging applications. First, their self-assembly behavior and gelling ability were investigated in water and water/dimethyl sulfoxide binary mixtures. Only salts having longer alkyl chains were able to give supramolecular hydrogels, whose properties were investigated by using a combined approach of fluorescence, resonance light scattering, and rheology measurements. Morphological information was obtained by scanning electron microscopy. In addition, conductive properties of organic salts in solution and gel state were analyzed. Imidazolium salts were successfully tested for their possible application as bioimaging and cytotoxic agents toward three cancer cell lines and a nontumoral epithelial cell line. Characterization of their behavior was performed by MTT and cell-based assays. Finally, the biological activity of hydrogels was also investigated. Collectively, our findings showed that naphthalimide-based imidazolium salts are promising theranostic agents and they were able to preserve their biological properties also in the gel phase.

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Section: ■ Experimental Sectionmentioning

confidence: 99%

Section: ■ Experimental Sectionmentioning

confidence: 99%