Dose Adjustment Associated Complications of Bone Morphogenetic Protein: A Longitudinal Assessment

Stefano, Frank De; Elarjani, Turki; Burks, Joshua D.; Burks, S. Shelby; Levi, Allan D.

doi:10.1016/j.wneu.2021.08.142

Cited by 7 publications

(3 citation statements)

References 19 publications

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“…In the future, the use of single factor assembled bioengineered materials will gradually decrease. This can create physiological disorders, such as the use of biomaterials to deliver BMP‐2 beyond the physiological dose to anterior spinal fusion, which can cause more complications than traditional autologous bone grafting 32 …”

Section: Discussionmentioning

confidence: 99%

A study of the role of multiple layer‐by‐layer assembled bionic extracellular matrix in promoting wound healing via activation of the Wnt signaling pathway

et al. 2023

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Wound healing is a multicellular collaborative process in which the adhesion and proliferation of fibroblasts in the wound is the basis for ensuring rapid wound healing, and in this process, it can promote the regeneration and remodeling of tissue and extracellular matrix. Studies have shown that Arg-Gly-Asp adhesive peptide (RGD) and basic fibroblast growth factor (bFGF) can stimulate the adhesion and proliferation of fibroblasts by activating the Wnt/β-catenin signaling pathway, respectively. This study adopts the principle of layer-by-layer self-assembly, and the binding force formed by electrostatic attraction and Schiff base was used to combine bFGF and RGD with collagen membrane to form a biomimetic membrane that is non-cytotoxic with strong biocompatibility that could promote soft tissue healing. The surface characteristics of MLCM and the sustained release concentration of bFGF in vitro were measured, and the effects of MLCM on cell viability, proliferation, migration, and wound healing by means of Wnt/catenin pathways were studied through cell experiments and animal experiments under the comparison of negative control groups and positive control groups. The results showed that MLCM could stimulate wound healing more actively and had a positive effect on cell activity, proliferation, and migration. During wound healing, MLCM activates the Wnt/β-catenin signaling pathway and inhibition of Wnt/β-catenin signaling pathway significantly reduces the positive effects of MLCM on wound healing.

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Section: Discussionmentioning

confidence: 99%

A study of the role of multiple layer‐by‐layer assembled bionic extracellular matrix in promoting wound healing via activation of the Wnt signaling pathway

et al. 2023

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“…However, several severe adverse events have been reported and the majority are believed to be a consequence of applying supra-physiological doses to the defect area [ 10 ]. Indeed, a meta-analysis indicates that the reduction of the rhBMP-2 dose correlates with a lower complication rate after performing a spinal fusion procedure [ 20 ]. Therefore, scaffold-based strategies to enhance the efficacy of rhBMP-2, and hence resulting in a reduction of the therapeutic dose required, represent an attractive modality to improve the overall safety profile.…”

Section: Discussionmentioning

confidence: 99%

Enhanced BMP-2-Mediated Bone Repair Using an Anisotropic Silk Fibroin Scaffold Coated with Bone-like Apatite

Deininger

Wagner

Heimel

et al. 2021

IJMS

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The repair of large bone defects remains challenging and often requires graft material due to limited availability of autologous bone. In clinical settings, collagen sponges loaded with excessive amounts of bone morphogenetic protein 2 (rhBMP-2) are occasionally used for the treatment of bone non-unions, increasing the risk of adverse events. Therefore, strategies to reduce rhBMP-2 dosage are desirable. Silk scaffolds show great promise due to their favorable biocompatibility and their utility for various biofabrication methods. For this study, we generated silk scaffolds with axially aligned pores, which were subsequently treated with 10× simulated body fluid (SBF) to generate an apatitic calcium phosphate coating. Using a rat femoral critical sized defect model (CSD) we evaluated if the resulting scaffold allows the reduction of BMP-2 dosage to promote efficient bone repair by providing appropriate guidance cues. Highly porous, anisotropic silk scaffolds were produced, demonstrating good cytocompatibility in vitro and treatment with 10× SBF resulted in efficient surface coating. In vivo, the coated silk scaffolds loaded with a low dose of rhBMP-2 demonstrated significantly improved bone regeneration when compared to the unmineralized scaffold. Overall, our findings show that this simple and cost-efficient technique yields scaffolds that enhance rhBMP-2 mediated bone healing.

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“…Many studies have demonstrated the utility of recombinant human BMP-2 (rhBMP-2) in enhancing fusion rates, so the use of rhBMP-2 has expanded in an off-label manner for various spinal fusion surgeries to assist with fusion in severe osteoporosis patients. However, there is a significant relation between the dose of rhBMP-2 use and the complication rates [ 8 ]. Concerns about postoperative complications of use of rhBMP-2 is a challenging issue of spine field, so more studies are needed.…”

mentioning

confidence: 99%

Optimal Strategies for the Treatment of Osteoporotic Spinal Diseases

Cho

2023

Neurospine

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Dose Adjustment Associated Complications of Bone Morphogenetic Protein: A Longitudinal Assessment

Cited by 7 publications

References 19 publications

A study of the role of multiple layer‐by‐layer assembled bionic extracellular matrix in promoting wound healing via activation of the Wnt signaling pathway

A study of the role of multiple layer‐by‐layer assembled bionic extracellular matrix in promoting wound healing via activation of the Wnt signaling pathway

Enhanced BMP-2-Mediated Bone Repair Using an Anisotropic Silk Fibroin Scaffold Coated with Bone-like Apatite

Optimal Strategies for the Treatment of Osteoporotic Spinal Diseases

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