Dosage regimen of arbekacin for methicillin‐resistant <i>Staphylococcus aureus</i> infection in newborns and infants

Yoshida, Koichi; Minowa, Hideki; Ebisu, Reiko; Uchida, Yumiko; Takahashi, Yukihiro; Yoshioka, Akira

doi:10.1111/j.1442-200x.2004.01971.x

Cited by 2 publications

(1 citation statement)

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“…According to the recent recommendations of the American Academy of Pediatrics' committee on infectious diseases, empirical antibiotic therapy of health care-associated MRSA infection includes vancomycin plus gentamicin 10) . Because the antibiotic susceptibility test of MRSA in our center has shown high rates of resistance to gentamicin, we chose other aminoglycoside, arbekacin as an alternative agent, based on the previous study about the successful treatment of MRSA infection of neonates and infants with arbekacin without significant side effects 11) . This is the first report of successful MRSA infective endocarditis of preterm infant treated with the antibiotic regimen of arbekacin with vancomycin.…”

Section: Discussionmentioning

confidence: 99%

Successfully treated infective endocarditis caused by methicillin-resistantStaphylococcus Aureusin extremely low birth weight infant

et al. 2016

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Survival rates of preterm infants have improved in the past few decades, and central venous catheters play an important role in the intensive medical treatment of these neonates. Unfortunately, these indwelling catheters increase the risk of intracardiac thrombosis, and they provide a nidus for microorganisms during the course of septicemia. Herein, we report a case of persistent bacteremia due to methicillin-resistant Staphylococcus aureus in an extremely low birth weight (ELBW) infant, along with vegetation observed on an echocardiogram, the findings which are compatible with a diagnosis of endocarditis. The endocarditis was successfully treated with antibiotic therapy, and the patient recovered without major complications. We suggest a surveillance echocardiogram for ELBW infants within a few days of birth, with regular follow-up studies when clinical signs of sepsis are observed.

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Section: Discussionmentioning

confidence: 99%

Successfully treated infective endocarditis caused by methicillin-resistantStaphylococcus Aureusin extremely low birth weight infant

et al. 2016

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Influences of dosage regimen and co-administration of low-molecular weight proteins and basic peptides on renal accumulation of arbekacin in mice

Murakami¹,

Nagai²,

Fukui³

et al. 2008

Journal of Antimicrobial Chemotherapy

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Dosage regimen of arbekacin for methicillin‐resistant Staphylococcus aureus infection in newborns and infants

Abstract: Nine newborns and infants with MRSA infection and various underlying diseases were successfully treated with TDM-based administration of ABK with no severe adverse reactions.

Cited by 2 publications

References 9 publications

Successfully treated infective endocarditis caused by methicillin-resistantStaphylococcus Aureusin extremely low birth weight infant

Successfully treated infective endocarditis caused by methicillin-resistantStaphylococcus Aureusin extremely low birth weight infant

Influences of dosage regimen and co-administration of low-molecular weight proteins and basic peptides on renal accumulation of arbekacin in mice

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