Dosage-Dependent Regulation of Pancreatic Cancer Growth and Angiogenesis by Hedgehog Signaling

Mathew, Esha; Zhang, Yaqing; Holtz, Alexander M.; Kane, Kevin T.; Song, Jane Y.; Allen, Benjamin L.; Magliano, Marina Pasca di

doi:10.1016/j.celrep.2014.09.010

Cited by 88 publications

(106 citation statements)

References 38 publications

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“…This cascade of events ultimately results in the regulation of the corresponding target genes (33). Certain components of the Hh signaling pathway such as PTCH1 and GLI1 are direct transcriptional targets, thus establishing a feedback loop that regulates the level of activity of this pathway (34).…”

Section: Introductionmentioning

confidence: 99%

Association between FOXM1 and hedgehog signaling pathway in human cervical carcinoma by tissue microarray analysis

et al. 2016

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Abstract. Forkhead box M1 (FOXM1) and hedgehog (Hh) signaling pathway are implicated in the formation and development of human tumors, including cervical cancer. Previous studies have indicated that FOXM1 may be a downstream target gene of the Hh signaling pathway, but their association in cervical cancer is largely unknown. In the present study, the expression of FOXM1 and Hh signaling molecules was evaluated by immunohistochemical analysis in a tissue microarray that contained 70 cervical cancer tissues and 10 normal cervical tissues. In addition, the association of these molecules with clinicopathological parameters, and the association between FOXM1 and various molecules involved in the Hh signaling pathway was investigated. The results indicated that FOXM1 and Hh signaling molecules were overexpressed in cervical cancer tissues. The protein expression levels of FOXM1, glioma-associated oncogene 1 (GLI1) and smoothened (SMO) correlated with the clinical stage of the tumors, while the protein expression levels of Sonic Hh (SHh), patched 1 (PTCH1) and GLI1 correlated with the pathological grade of the tumors. The expression levels of GLI1 were lower in tissues without lymph node metastasis than in tissues with lymph node metastasis. In addition, FOXM1 expression correlated with GLI1, SHh and PTCH1 expression in cancer tissues. These findings confirmed the participation of FOXM1 and the Hh signaling pathway in cervical cancer. Furthermore, the finding that FOXM1 may be a downstream target gene of the Hh signaling pathway in cervical cancer provides a potential novel diagnostic and therapeutic target for cervical cancer.

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Section: Introductionmentioning

confidence: 99%

Association between FOXM1 and hedgehog signaling pathway in human cervical carcinoma by tissue microarray analysis

et al. 2016

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“…4). Finally, we looked for the expression of GAS1 in fibroblasts since they are present in the stroma of the CP (Emerich et al 2005a), and a previous report indicated that these cells express GAS1 in the pancreas (Mathew et al 2014). However, we could not observe co-localization of GAS1 with a specific marker for fibroblasts (α-SMA) (Fig.…”

Section: Gas1 Is Expressed In the Stroma Of The Choroid Plexusmentioning

confidence: 99%

GAS1 is present in the cerebrospinal fluid and is expressed in the choroid plexus of the adult rat

Ayala-Sarmiento

Estudillo

Pérez‐Sánchez

et al. 2016

Histochem Cell Biol

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Growth arrest specific 1 (GAS1) is a GPI-anchored protein that inhibits proliferation when overexpressed in tumors but during development it promotes proliferation and survival of different organs and tissues. This dual ability is caused by its capacity to interact both by inhibiting the signaling induced by the glial cell line-derived neurotrophic factor and by facilitating the activity of the sonic hedgehog pathway. GAS1 is expressed as membrane bound in different organs and as a secreted form by glomerular mesangial cells. In the developing central nervous system, GAS1 is found in neural progenitors; however, it continues to be expressed in the adult brain. Here, we demonstrate that soluble GAS1 is present in the cerebrospinal fluid (CSF) and it is expressed in the choroid plexus (CP) of the adult rat, the main producer of CSF. Additionally, we confirm the presence of GAS1 in blood plasma and liver of the adult rat, the principal source of blood plasma proteins. The pattern of expression of GAS1 is perivascular in both the CP and the liver. In vitro studies show that the fibroblast cell line NIH/3T3 expresses one form of GAS1 and releases two soluble forms into the supernatant. Briefly, in the present work, we show the presence of GAS1 in adult rat body fluids focusing in the CSF and the CP, and suggest that secreted GAS1 exists as two different isoforms.

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“…Last but not least, another crucial signalling pathway worth discussing is the Hedgehog signalling pathway which has a dual role in endocrine pancreatic regeneration [ 117 ]. For instance, Hebrok et al [ 118 ] have shown that Indian hedgehog (Ihh), together with Patched-1 (Ptc-1), a receptor and negative regulator of hedgehog activity, is expressed in pancreatic tissue.…”

Section: Pancreasmentioning

confidence: 99%

Dental Stem Cell Differentiation Toward Endodermal Cell Lineages: Approaches to Control Hepatocytes and Beta Cell Transformation

Gnanasegaran¹,

Govindasamy²,

Nathan³

et al. 2016

Dental Stem Cells

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Dosage-Dependent Regulation of Pancreatic Cancer Growth and Angiogenesis by Hedgehog Signaling

Cited by 88 publications

References 38 publications

Association between FOXM1 and hedgehog signaling pathway in human cervical carcinoma by tissue microarray analysis

Association between FOXM1 and hedgehog signaling pathway in human cervical carcinoma by tissue microarray analysis

GAS1 is present in the cerebrospinal fluid and is expressed in the choroid plexus of the adult rat

Dental Stem Cell Differentiation Toward Endodermal Cell Lineages: Approaches to Control Hepatocytes and Beta Cell Transformation

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