Dorzolamide-loaded PLGA/vitamin E TPGS nanoparticles for glaucoma therapy: Pharmacoscintigraphy study and evaluation of extended ocular hypotensive effect in rabbits

RETRACTED ARTICLE: Brain-targeted glycyrrhizic-acid-loaded surface decorated nanoparticles for treatment of cerebral ischaemia and its toxicity assessment

“…A smooth surface with spherical shape (SEM analysis) as shown in Figure 12(a) and a proper sphericity (TEM analysis) with a particle size <300 nm, as shown in Figure 12(b), was observed for CS-GA-PCL-NPs. In contrast, a crystalline structure [69,70] with slow aqueous permeability of PVA led towards a steady degradation as well as drug release for PCL-NPs [24,43]. However, for GA, the addition of CS (high water permeable nature) resulted an enhanced drug release rate from PCL-NPs [21] i.e.…”

“…In addition, the smaller diameter helps NPs to cross the mucosal membrane conveniently and access the brain effectively through endocytic mechanism [21]. To understand the effectiveness of NPs, various studies are available which showed an intensified bioavailability for various drugs such as; PVA-NPs and PLGA-NPs [22][23][24][25][26] and PCL-NPs as applied i.n. for brain targeting [27][28][29][30].…”

Quantification and Brain Targeting of Eugenol-Loaded Surface Modified Nanoparticles Through Intranasal Route in the Treatment of Cerebral Ischemia

“…Based on the in vitro release pattern i. e. > 80 %, X1-CS-coated-EUG-PCL-NPs was found the best nanoformulation. On the other hand, PCL-NPs due to crystalline structure [66] alongwith less water-permeability for PVA resulted a slow degradation and hence exhibited a slow drug release [39]; however addition of CS enhanced the release rate for EUG which is imparted by high water permeable nature of CS [32]. The release profile for EUG from PCL-NPs showed a high drug release i. e. after 12 h, with a successive sustain release.…”

“…The importance of nanoparticles is evident with the successful application of various NPs as reported; PCL-NPs [poly(ε-caprolactone) nanoparticles] used for i.n. brain targeting [33][34][35][36], PLGA-NPs and PVA-NPs for drug delivery [37][38][39][40][41], which exhibited an enhanced bioavailability for administered drugs. Chitosan (CS) due to mucoadhesive property is also gaining more interest nowadays [42,43] as it offers the added advantages such as; a prolong release due to mucoadhesive nature and hence an increased absorption and bioavailability [32].…”

Investigations on Polymeric Nanoparticles for Ocular Delivery

“…The cross sections of corneas incubated with phosphate buffer saline (negative control), sodium dodecyl sulfate, 0.1%, w/v (positive control), and marketed formulation (Iotim5) were prepared in the same manner. The corneal slides were evaluated under light microscope (Leica Microsystems CMS (DM 4000), Germany) and the images were captured [33].…”