Dorzolamide and ocular blood flow in previously untreated glaucoma patients: a controlled double‐masked study

Abstract

ABSTRACT.Purpose: The aim of this study was to investigate the haemodynamic effects of topical dorzolamide treatment in eyes with newly detected and previously untreated glaucoma. Methods: Forty-seven patients with open angle glaucoma were consecutively randomized to dorzolamide versus placebo TID during a 6-week double-masked treatment trial. Ocular blood flow was investigated at baseline and on therapy using colour Doppler imaging of the retrobulbar vessels and scanning laser ophthalmoscope fluorescein angiograms of the retinal circulation. Results: None of the flow parameters, retrobulbar or retinal, changed significantly on therapy when the results were analysed with the Bonferroni method. Analysis with non-simultaneous tests also failed to reveal any significant changes either in retrobulbar flow velocities in the central retinal artery, ophthalmic artery or in the short posterior ciliary arteries, or in the retinal parameters (arm-retina time, arteriovenous passage time, mean dye velocity or macular capillary velocity), while capillary velocities at the optic disc decreased significantly in the dorzolamide group (P Ω 0.03). Intraocular pressure reduction was significantly more pronounced in the dorzolamide group (P Ω 0.002), with ª4.8 ∫ 2.9 mmHg (P ∞ 0.0001) versus ª1.8 ∫ 3.0 mmHg in the placebo group (P Ω 0.006). Conclusions: The present study indicated no measurable vascular effects from topical dorzolamide treatment in previously untreated glaucoma eyes.

Hormone therapy and ophthalmic artery blood flow changes in women with primary open-angle glaucoma

“…This confirms previous studies that underlined that normal-tension glaucoma and chronic, open-angle glaucoma are characteristically associated with reduced flow velocities and increased ophthalmic artery resistance indexes. [31][32][33][34][35][36] Although it has been reported that aging, increased plasma viscosity, and atherosclerosis render the monkey retina susceptible to ischemia, 37 in the present study no differences in age and plasma viscosity 7 values were observed either in normal, healthy women or in those who presented with ocular disease. Thus, other factors may intervene in reducing retrobulbar perfusion both in normal-tension and open-angle glaucoma.…”

A Comparison of the Long-Term Effects of Dorzolamide 2% and Brinzolamide 1%, Each Added to Timolol 0.5%, on Retrobulbar Hemodynamics and Intraocular Pressure in Open-Angle Glaucoma Patients

“…However, the results of our study are in contradiction to the fi ndings reported by Bergstrand and colleagues 23 in previously untreated glaucoma patients. These authors did not fi nd dorzolamide to exert signifi cant hemodynamic effects.…”

“…The end-diastolic velocities and RI, in all retrobulbar vessels, reported by Bergstrand and colleagues 23 seemed to be signifi cantly lower than those reported by our group. These differences in the retrobulbar hemodynamics between the two study patients may be clinically relevant.…”

Comparative Analysis of the Effects of Brimonidine and Dorzolamide on Ocular Blood Flow Velocity in Patients with Newly Diagnosed Primary Open-Angle Glaucoma

“…[28][29][30] However, Latina and colleagues 31 found that dorzolamide-not brimonidine-caused a statistically significant and sustained improvement in blood flow from baseline in the superotemporal and nasal peripapillary retinal regions using SLDF as examining tool. Scanning laser Doppler flowmeter is a noninvasive method, which allows blood flow measurement in specific retinal areas.…”