Dorsolateral Prefrontal γ-Aminobutyric Acid in Men Predicts Individual Differences in Rash Impulsivity

Boy, Frédéric; Evans, John; Edden, Richard A.E.; Lawrence, Andrew D.; Singh, Krish Devi; Husain, Masud; Sumner, Petroc

doi:10.1016/j.biopsych.2011.05.030

Cited by 126 publications

(118 citation statements)

References 85 publications

(118 reference statements)

Supporting

Mentioning

108

Contrasting

Order By: Relevance

“…Preclinical studies suggest that reductions in or lower levels of GABA are associated with greater impulsivity (Boy et al 2011; Murphy et al 2012; Paine et al 2011). We have previously shown that [ 11 C]Ro15‐4513 is sensitive to GABA levels, and since it is an inverse benzodiazepine agonist, lower levels of GABA would be associated with higher [ 11 C]Ro15‐4513 binding.…”

Section: Discussionmentioning

confidence: 99%

“…Whilst GABA measured this way is predominantly metabolic in origin (Myers et al 2014; Myers et al 2016b), it is interesting that a lowered magnetic resonance spectroscopy GABA signal ([GABA+]) in HV has in some studies been associated with higher levels of impulsivity. For instance, it has been shown that [GABA+] levels in dorsolateral prefrontal regions negatively correlate with urgency impulsivity (Boy et al 2011); low [GABA+] in perigenual anterior cingulate cortex was associated with greater delay aversion on Cambridge gambling task (Fujihara et al 2015) and higher scores on self‐report Barratt Impulsiveness Scale‐11 in one study (Silveri et al 2013) but not another (Janes et al 2013). Lower [GABA+] in the striatum is associated with poorer impulse control in Go‐NoGo task (Quetscher et al 2015).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evidence for GABA‐A receptor dysregulation in gambling disorder: correlation with impulsivity

et al. 2016

View full text Add to dashboard Cite

As a behavioural addiction, gambling disorder (GD) provides an opportunity to characterize addictive processes without the potentially confounding effects of chronic excessive drug and alcohol exposure. Impulsivity is an established precursor to such addictive behaviours, and GD is associated with greater impulsivity. There is also evidence of GABAergic dysregulation in substance addiction and in impulsivity. This study therefore investigated GABAA receptor availability in 15 individuals with GD and 19 healthy volunteers (HV) using [11C]Ro15‐4513, a relatively selective α5 benzodiazepine receptor PET tracer and its relationship with impulsivity. We found significantly higher [11C]Ro15‐4513 total distribution volume (VT) in the right hippocampus in the GD group compared with HV. We found higher levels of the ‘Negative Urgency’ construct of impulsivity in GD, and these were positively associated with higher [11C]Ro15‐4513 VT in the amygdala in the GD group; no such significant correlations were evident in the HV group. These results contrast with reduced binding of GABAergic PET ligands described previously in alcohol and opiate addiction and add to growing evidence for distinctions in the neuropharmacology between substance and behavioural addictions. These results provide the first characterization of GABAA receptors in GD with [11C]Ro15‐4513 PET and show greater α5 receptor availability and positive correlations with trait impulsivity. This GABAergic dysregulation is potential target for treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evidence for GABA‐A receptor dysregulation in gambling disorder: correlation with impulsivity

et al. 2016

View full text Add to dashboard Cite

show abstract

“…In a study of children with ADHD, lower GABA levels in a region including parts of the primary somatosensory and motor cortices have been reported (Edden et al, 2012). In healthy adolescents and adults, two recent studies showed a negative association of GABA levels in the dorsolateral prefrontal cortex with impulsivity (Boy et al, 2011;Silveri et al, 2013). Despite these studies, Hayes argues that there is still a lack of research on GABA in the general context of impulsivity (Hayes et al, 2014).…”

Section: Introductionmentioning

confidence: 97%

Impulsivity and Aggression in Female BPD and ADHD Patients: Association with ACC Glutamate and GABA Concentrations

Ende

Cackowski

Eijk

et al. 2015

Neuropsychopharmacol

118

View full text Add to dashboard Cite

Borderline personality disorder (BPD) and attention-deficit-hyperactivity disorder (ADHD) are both characterized by high impulsivity and difficulties in controlling anger and aggression. In BPD, comorbid ADHD may further increase impulsivity. For both disorders, altered MR spectroscopy levels of the neurotransmitters glutamate and GABA as well as some correlations with impulsivity were previously reported. The objective of this study was to investigate the neurotransmitters glutamate and GABA in relation to impulsivity and aggression as expressed in the anterior cingulate cortex (ACC) in groups of female patients with BPD and ADHD, respectively. Associations of glutamate and GABA levels with further BPD (symptom severity) and ADHD aspects (hyperactivity and inattention) were exploratively evaluated. 1H MR spectra were acquired at 3T to determine glutamate to total creatine ratios (Glu/tCr) and GABA levels from the ACC in a BPD group (n = 26), an ADHD group (n = 22), and a healthy control (HC) group (n = 30); all participants were females. Both patient groups showed higher scores on self-reported impulsivity, anger, and aggression compared with HCs. ACC GABA levels were significantly lower in ADHD than HC. Although measures of impulsivity were positively related to glutamate and negatively to GABA, for aggression only a negative correlation with GABA could be demonstrated. These data provide human in vivo evidence for the role of ACC Glu/tCr and GABA in impulsivity and aggression. If distinct associations of Glu/tCr and GABA for BPD and ADHD can be confirmed in future studies, this might yield implications for more specific pharmacological treatments.

show abstract

“…It is characterized by rapid and unplanned reactions to stimuli before thorough processing of information (Arce and Santisteban, 2006). In the DSM (DSM-IV-TR; American Psychiatric Association 2000), impulsivity is the second most frequent symptom (Boy et al, 2011). There is a growing interest in understanding impulsivity among healthy populations as this trait can be interpreted along a dimension, but the underlying mechanisms across the full range have not been clarified yet (Dimoska and Johnstone, 2007;Kam et al, 2012;Stanford et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Generalized lapse of responding in trait impulsivity indicated by ERPs: The role of energetic factors in inhibitory control

Kóbor

Takács

Honbolygó

et al. 2014

International Journal of Psychophysiology

View full text Add to dashboard Cite

Impaired inhibitory control is one of the still debated underlying mechanisms of trait impulsivity. The Cognitive Energetic Model accounts for the role of energetic factors mediating task performance. The aim of the present study was to compare inhibitory control functions of adults with high and low impulsivity by using a modified Eriksen flanker task.Adults were classified as impulsive (n = 15) and control (n = 15) participants based on the Barratt Impulsiveness Scale. Flanker trials had three levels of required effort manipulated by visual degradation. We analyzed RT, accuracy, and ERPs time-locked to the flanker stimuli.Reaction time of impulsive participants was generally slower than that of controls', but accuracy was similar across groups. N2c showed that monitoring of response conflict was modulated by task requirements independent of impulsivity. The P3 latency was delayed in the impulsive group indicating slower stimulus evaluation. The P3 amplitude was reduced in the control group for moderately degraded incongruent trials suggesting that the attentional resources were employed less. The Lateralized Readiness Potential (LRP) peaked later in the impulsive group irrespective of experimental effects. The amplitude of the positive-going LRP recorded in the incongruent condition was comparable across groups, but the latency was delayed partly supporting a stronger susceptibility to stimulus interference of impulsive participants. Their delayed incongruent negative-going LRP reflected a weaker response inhibition and a slower correct response organization. In conclusion, impaired inhibitory functions in impulsivity could not be unequivocally demonstrated, but we found a generalized lapse of motor activation.

show abstract

Dorsolateral Prefrontal γ-Aminobutyric Acid in Men Predicts Individual Differences in Rash Impulsivity

Cited by 126 publications

References 85 publications

Evidence for GABA‐A receptor dysregulation in gambling disorder: correlation with impulsivity

Evidence for GABA‐A receptor dysregulation in gambling disorder: correlation with impulsivity

Impulsivity and Aggression in Female BPD and ADHD Patients: Association with ACC Glutamate and GABA Concentrations

Generalized lapse of responding in trait impulsivity indicated by ERPs: The role of energetic factors in inhibitory control

Contact Info

Product

Resources

About