Dorsal/ventral parcellation of the amygdala: Relevance to impulsivity and aggression

Gopal, Abilash A.; Clark, Erika; Allgair, Amy; D’Amato, Christopher; Furman, Margery; Gansler, David A.; Fulwiler, Carl E.

doi:10.1016/j.pscychresns.2012.10.010

Cited by 42 publications

(31 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, as discussed in our previous study , the specific individual subdivisions differentially contribute to the connections between the amygdala and cortical and subcortical brain regions (Gopal et al, 2013;Mishra et al, 2014;Roy et al, 2009;Saygin et al, 2011). In this study, the amygdala was considered as a singular structure, which likely masked the independent functions and patterns of connectivity of the individual subdivisions.…”

Section: Methodological Issues and Further Discussionmentioning

confidence: 93%

Longitudinal Alteration of Amygdalar Functional Connectivity in Mild Cognitive Impairment Subjects Revealed by Resting-State fMRI

Yao

Zhou²,

Zhang³

et al. 2014

Brain Connectivity

View full text Add to dashboard Cite

Mild cognitive impairment (MCI) is considered to be the prodromal stage of Alzheimer's disease. The amygdala, which is considered to be a hub, has been shown to have widespread brain connections with many cortical regions. Longitudinal alterations in the functional connectivity of the amygdala remain unclear in MCI. We hypothesized that the impairment in the amygdala-cortical loop would be more severe in a follow-up MCI group than in a baseline MCI group and that these alterations would be related to the disease processes. To test this hypothesis, we used resting-state functional magnetic resonance imaging to investigate alterations in amygdalar connectivity patterns based on longitudinal data from 13 MCI subjects (8 males and 5 females). Compared to the baseline, decreases in functional connectivity were mainly found located between the amygdala and regions at the conjunction of the temporal-occipital system and the regions included in the default mode network in the follow-up MCI individuals. The alterations in the functional connectivity of the identified regions were validated in an independent dataset. Specifically, reduced amygdalar connectivity was significantly correlated with cognitive abilities. These findings indicate that impairments in the functional connectivity of the amygdala may be potential biomarkers of the progression of MCI.

show abstract

Section: Methodological Issues and Further Discussionmentioning

confidence: 93%

Longitudinal Alteration of Amygdalar Functional Connectivity in Mild Cognitive Impairment Subjects Revealed by Resting-State fMRI

Yao

Zhou²,

Zhang³

et al. 2014

Brain Connectivity

View full text Add to dashboard Cite

show abstract

“…A recent theory of psychopathy has emphasized the importance of differential responses within two major subregions of the amygdala (Moul, Killcross, & Dadds, 2012), a point not addressed by any current studies of youth AB, though shown to be important in studies of AB in adults (Carré, Fisher, Manuck, & Hariri, 2012; Gopal et al, 2013). …”

Section: Overview Of Developmental and Neuroimaging Methodsmentioning

confidence: 98%

Understanding youth antisocial behavior using neuroscience through a developmental psychopathology lens: Review, integration, and directions for research

Hyde

Shaw

Hariri

2013

Developmental Review

View full text Add to dashboard Cite

Youth antisocial behavior (AB) is an important public health concern impacting perpetrators, victims, and society. Functional neuroimaging is becoming a more common and useful modality for understanding neural correlates of youth AB. Although there has been a recent increase in neuroimaging studies of youth AB and corresponding theoretical articles on the neurobiology of AB, there has been little work critically examining the strengths and weaknesses of individual studies and using this knowledge to inform the design of future studies. Additionally, research on neuroimaging and youth AB has not been integrated within the broader framework of developmental psychopathology. Thus, this paper provides an in-depth review of the youth AB functional neuroimaging literature with the following goals: 1. to evaluate how this literature has informed our understanding of youth AB, 2. to evaluate current neuroimaging studies of youth AB from a developmental psychopathology perspective with a focus on integrating research from neuroscience and developmental psychopathology, as well as placing this research in the context of other related areas (e.g., psychopathy, molecular genetics), and 3. to examine strengths and weaknesses of neuroimaging and behavioral studies of youth AB to suggest how future studies can develop a more informed and integrated understanding of youth AB.

show abstract

“…[9] The amygdala is part of the limbic system and relevant to fear, anxiety, impulsivity and aggression. [15,17] Prefrontal cortex–amygdala circuits are responsible for several mental diseases, including aggression. [18] Therefore, amygdalotomy may alleviate aggression and psychiatric symptoms through projections and chemistry of the prefrontal cortex-amygdala circuits and amygdala.…”

Section: Discussionmentioning

confidence: 99%

“…[4,17] Therefore, we chose amygdalotomy for treatment of aggression of our patient instead of other encephalic regions, as reported elsewhere. Besides aggression, the patient had other psychiatric symptoms, which were treated with capsulotomy because this procedure can achieve more satisfactory outcomes and fewer side effects, as compared to other encephalic regions.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Bilateral anterior capsulotomy and amygdalotomy for mental retardation with psychiatric symptoms and aggression

2017

View full text Add to dashboard Cite

show abstract

Dorsal/ventral parcellation of the amygdala: Relevance to impulsivity and aggression

Cited by 42 publications

References 52 publications

Longitudinal Alteration of Amygdalar Functional Connectivity in Mild Cognitive Impairment Subjects Revealed by Resting-State fMRI

Longitudinal Alteration of Amygdalar Functional Connectivity in Mild Cognitive Impairment Subjects Revealed by Resting-State fMRI

Understanding youth antisocial behavior using neuroscience through a developmental psychopathology lens: Review, integration, and directions for research

Bilateral anterior capsulotomy and amygdalotomy for mental retardation with psychiatric symptoms and aggression

Contact Info

Product

Resources

About