Dorsal-ventral gradient in vulnerability of CA1 hippocampus to ischemia: a combined histological and electrophysiological study

Ashton, David; Reempts, Jos Van; Haseldonckx, Marc; Willems, Roland

doi:10.1016/0006-8993(89)90842-1

Cited by 57 publications

(25 citation statements)

References 15 publications

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“…Similar to guinea pigs, in humans, there is a possibility that, at least in a reduced population of individuals, the ventralmost portion of the hippocampus and the related parahippocampal regions are supplied by a single arterial branch with little compensatory anastomotic circuits available. Our results are in agreement with the reported vulnerability of the hippocampus to transient global ischemia (Pulsinelli et al, 1982;Ashton et al, 1989;Sieber et al, 1995). It has been demonstrated in animal models of transient bilateral carotid occlusion or fourvessel occlusion that, in rats and in other mammals, the hippocampus always is injured by ischemia (Pulsinelli et al, 1982;Sieber et al, 1995).…”

Section: Discussionsupporting

confidence: 94%

Arterial supply of limbic structures in the guinea pig

et al. 1999

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Section: Discussionsupporting

confidence: 94%

Arterial supply of limbic structures in the guinea pig

et al. 1999

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“…These hippocampal regions have been related to AD, vascular disease and ageing. HC could therefore play a role in neurodegenerative, vascular and age-related hippocampal disease [11, 12]. A possible relation to AD, however, appears less likely because even though HC was frequently found in patients with AD, Wegiel et al reported that only 4% of patients with Down syndrome showed VFC while 96% were affected by AD, opposing a common pathological mechanism [2].…”

Section: Discussionmentioning

confidence: 99%

Hippocampal calcification on brain CT: prevalence and risk factors in a cerebrovascular cohort

et al. 2018

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ObjectivesRecently, hippocampal calcification as observed on brain CT examinations was identified in over 20% of people over 50 years of age and a relation between hippocampal calcification and cognitive decline was shown. We determined the prevalence and investigated the vascular risk factors of hippocampal calcification in patients with cerebrovascular disease.MethodsHippocampal calcification was scored bilaterally on presence and severity on CT examinations in a cohort of 1130 patients with (suspected) acute ischaemic stroke. Multivariable logistic regression analysis, adjusting for age and gender as well as adjusting for multiple cardiovascular disease risk factors, was used to determine risk factors for hippocampal calcification.ResultsHippocampal calcification was present in 381 (34%) patients. Prevalence increased with age from 8% below 40 to 45% at 80 years and older. In multivariable logistic regression analysis, age per decile (OR 1.41 [95% CI 1.26–1.57], p < 0.01), hypertension (OR 0.74 [95% CI 0.56–0.99], p = 0.049), diabetes mellitus (OR 1.57 [95% CI 1.10–2.25], p = 0.01) and hyperlipidaemia (OR 1.63 [95% CI 1.20–2.22], p < 0.01) were significantly associated with hippocampal calcification.ConclusionsHippocampal calcification was a frequent finding on CT in this cohort of stroke patients and was independently positively associated with hyperlipidaemia and diabetes mellitus, suggesting an atherosclerotic origin.Key Points • Hippocampal calcification is prevalent in over 30% of cerebrovascular disease patients. • Prevalence increases from 8% below 40 to 45% over 80 years. • Hippocampal calcification is associated with cardiovascular risk factors hyperlipidaemia and diabetes mellitus. Electronic supplementary materialThe online version of this article (10.1007/s00330-018-5372-8) contains supplementary material, which is available to authorized users.

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“…2a). Over the hippocampal long axis, posterior CA1 is differentially affected by vascular disease 59 . Although a systematic investigation of age-related dentate gyrus alterations over the hippocampal long axis has not yet been completed, a recent study suggests that age-related pattern separation defects occur in relatively posterior aspects 58 .…”

Section: Hippocampal Regional Vulnerabilitymentioning

confidence: 99%

A pathophysiological framework of hippocampal dysfunction in ageing and disease

et al. 2011

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The hippocampal formation has been implicated in a growing number of disorders, from Alzheimer's disease and cognitive ageing to schizophrenia and depression. How can the hippocampal formation, a complex circuit that spans the temporal lobes, be involved in a range of such phenotypically diverse and mechanistically distinct disorders? Recent neuroimaging findings indicate that these disorders differentially target distinct subregions of the hippocampal circuit. In addition, some disorders are associated with hippocampal hypometabolism, whereas others show evidence of hypermetabolism. Interpreted in the context of the functional and molecular organization of the hippocampal circuit, these observations give rise to a unified pathophysiological framework of hippocampal dysfunction.

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Dorsal-ventral gradient in vulnerability of CA1 hippocampus to ischemia: a combined histological and electrophysiological study

Cited by 57 publications

References 15 publications

Arterial supply of limbic structures in the guinea pig

Arterial supply of limbic structures in the guinea pig

Hippocampal calcification on brain CT: prevalence and risk factors in a cerebrovascular cohort

A pathophysiological framework of hippocampal dysfunction in ageing and disease

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