Dorsal Striatal Dopamine, Food Preference and Health Perception in Humans

Wallace, Deanna L.; Aarts, Esther; Dang, Linh C.; Greer, Stephanie; D’Esposito, Mark

doi:10.1371/journal.pone.0096319

Cited by 21 publications

(20 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most anterior ¼ of cerebellar gray was removed from the reference region to limit contamination of signal from the substantia nigra and ventral tegmental area. Exclusion of the anterior portion of the cerebellar gray has been reported previously ( Aarts et al , 2014 ; Berry et al , 2016 ; Braskie et al , 2011 ; Braskie et al , 2008 ; Dang et al , 2017 ; Dang et al , 2012a ; Dang et al , 2012b , 2013 ; Dang et al , 2016 ; Klostermann et al , 2012 ; Smith et al , 2016 ; Wallace et al , 2014 ), and was performed by manually removing the anterior ¼ of coronal slices from individual participants’ native space cerebellar gray FreeSurfer segmentation using Mango software ( http://ric.uthscsa.edu/mango/ ). K i images were generated from PET frames corresponding to 25 to 90 min ( Ito et al , 2006 ; Ito et al , 2007 ), which represent the amount of tracer accumulated in the brain relative to the reference region.…”

Section: Methodsmentioning

confidence: 99%

Dopamine Synthesis Capacity is Associated with D2/3 Receptor Binding but Not Dopamine Release

Berry

Shah

Furman

et al. 2017

Neuropsychopharmacol.

View full text Add to dashboard Cite

Positron Emission Tomography (PET) imaging allows the estimation of multiple aspects of dopamine function including dopamine synthesis capacity, dopamine release, and D2/3 receptor binding. Though dopaminergic dysregulation characterizes a number of neuropsychiatric disorders including schizophrenia and addiction, there has been relatively little investigation into the nature of relationships across dopamine markers within healthy individuals. Here we used PET imaging in 40 healthy adults to compare, within individuals, the estimates of dopamine synthesis capacity (Ki) using 6-[18F]fluoro-l-m-tyrosine ([18F]FMT; a substrate for aromatic amino acid decarboxylase), baseline D2/3 receptor-binding potential using [11C]raclopride (a weak competitive D2/3 receptor antagonist), and dopamine release using [11C]raclopride paired with oral methylphenidate administration. Methylphenidate increases synaptic dopamine by blocking the dopamine transporter. We estimated dopamine release by contrasting baseline D2/3 receptor binding and D2/3 receptor binding following methylphenidate. Analysis of relationships among the three measurements within striatal regions of interest revealed a positive correlation between [18F]FMT Ki and the baseline (placebo) [11C]raclopride measure, such that participants with greater synthesis capacity showed higher D2/3 receptor-binding potential. In contrast, there was no relationship between [18F]FMT and methylphenidate-induced [11C]raclopride displacement. These findings shed light on the nature of regulation between pre- and postsynaptic dopamine function in healthy adults, which may serve as a template from which to identify and describe alteration with disease.

show abstract

Section: Methodsmentioning

confidence: 99%

Dopamine Synthesis Capacity is Associated with D2/3 Receptor Binding but Not Dopamine Release

Berry

Shah

Furman

et al. 2017

Neuropsychopharmacol.

View full text Add to dashboard Cite

show abstract

“…Pictures of eighty food items ([23], also see Supplementary Table), were used in which subjects were asked to rate the items in separate blocks. Subjects were first asked to rate the degree to which they “desired” or “wanted” a serving size of each of the eighty food items presented (scale of 1 (strongly do not want) to 4 (strongly want)) with the question “On a scale from 1 to 4, rate how much you want each food item right now”.…”

Section: Methodsmentioning

confidence: 99%

“…We also used these resources to obtain objective health scores to approximately balance the task with objectively-rated “healthy” (objective ratings of 1 to 3) and objectively-rated “unhealthy” (objective ratings of −1 to −3) foods. Food items were selected based on two previously published reports by our research group [20, 23]. Also see Supplementary Table for list of the 80 food items, average letter grade from website, nutritional information, averages and standard deviations of desired scores from subjects, as well as averages and standard deviations of self-rated health scores from subjects and derived objective health scores.…”

Section: Methodsmentioning

confidence: 99%

Genotype status of the dopamine-related catechol-O-methyltransferase (COMT) gene corresponds with desirability of “unhealthy” foods

Wallace

Aarts

Uquillas³

et al. 2015

Appetite

Self Cite

View full text Add to dashboard Cite

The role of dopamine is extensively documented in weight regulation and food intake in both animal models and humans. Yet the role of dopamine has not been well studied in individual differences for food desirability. Genotype status of the dopamine-related catechol-O-methyltransferase (COMT) gene has been shown to influence dopamine levels, with greater COMT enzymatic activity in val/val individuals corresponding to greater degradation of dopamine. Decreased dopamine has been associated with poorer cognitive control and diminished goal-directed behavior in various behavioral paradigms. Additionally, dopaminergic-rich regions such as the frontal cortex and dorsal striatum have been shown to be important for supporting food-related decision-making. However, the role of dopamine, as assessed by COMT genotype status, in food desirability has not been fully explored. Therefore, we utilized an individual’s COMT genotype status (n=61) and investigated food desirability based on self-rated “healthy” and “unhealthy” food perceptions. Here we found val/val individuals (n=19) have greater desirability for self-rated “unhealthy” food items, but not self-rated “healthy” food items, as compared to val/met (n=24) and met/met (n=18) individuals (p<0.005). Utilizing an objective health measure for the food items, we also found val/val and val/met individuals have greater desirability for objectively defined “unhealthy” food items, as compared to met/met individuals (p<0.01). This work further substantiates a role of dopamine in food-related behaviors and more specifically in relationship to food desirability for “unhealthy” food items.

show abstract

“…To our knowledge, only one study looked at the relationship of central dopamine transmission and food preference in humans. Wallace and colleagues combined a food rating paradigm, asking for wanting and perceived healthiness of various food items, with PET of to measure striatal dopamine synthesis binding 71 . They report higher preference for perceived healthy, but not objectively healthy food items in people with lower striatal dopamine synthesis, supporting the hypothesis that endogenous dopamine is indeed related to food preference.…”

Section: Discussionmentioning

confidence: 99%

Differences in intake of high-fat high-sugar diet are related to variations in central dopamine in humans

Hartmann

Pauli

Janssen

et al. 2019

Preprint

View full text Add to dashboard Cite

Running headHigh-fat high-sugar diet relates to central dopamine in humans *Authors contributed equally to the study. of 1 43We thank Arno Villringer and his coworkers of the Department of Neurology (MaxPlanck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany) for providing lab space and additional resources. We further thank SusePrejawa for administrative support, Ramona Menger and Sylvia Stasch for preparing the intervention, and Bettina Johst and Steven Kalinke for cognitive task programming. Furthermore we thank Emmy Kaspar for participating in the preparation of the study, Lisa Ulbrich, Pauline Baßler, and Denise Linke for testing participants. Special thanks to Mathis Lammert, Linda Grasser, Lisa Leyendecker, Franziska Schwachheim for performing the blood drawings and physiological measurements. We thank Lydia Hellrung for helpful input regarding the APTD procedure. The authors have stated explicitly that there are no conflicts of interest in connection with this article. Performed experiments, analyzed data and co-wrote the paper. L.K.P.; Designed and performed experiments, analyzed data and provided feedback for the paper. L.K.J.;Designed experiments, analyzed data and co-wrote the paper. S.H.; developed the lowprotein diet plan for successful intervention. U.C.; coordinated and supervised the analyses of amino acids and metabolic parameters. A.H.; supervised the research, conceived the original idea, designed experiments, helped interpreting data and provided feedback for the paper. of 2 43 AbstractObesity is associated with alterations in dopaminergic transmission and cognitive function. Recent findings from rodent studies suggest that diets rich in saturated fat and refined sugars (HFS) induce changes in the dopamine system independent of excessive body weight. However, so far the impact of HFS on the human brain has not been investigated. Here, we compared the effect of dietary dopamine depletion on dopamine dependent cognitive tasks between two groups that differ in habitual intake of dietary fat and sugar. Specifically, we used a double-blind within-subject crossover design to compare the effect of acute phenylalanine/tyrosine depletion (APTD) on a reinforcement learning and a working memory task, in two groups that are on opposite ends of the spectrum of self-reported HFS intake (low vs. high intake: LFS vs. HFS group). We tested 31 healthy young women, who were matched for BMI (mostly normal weight to overweight) and IQ. Depletion of central dopamine reduced the working memory specific performance on the operation span task (OSPAN) in the LFS, but not in the HFS group (p = 0.023, r = 0.210). Learning from positive and negative reinforcement (probabilistic selection task: PST) was increased in both diet groups after dopamine depletion (p = 0.048, r = 0.144). As secondary exploratory research question we measured peripheral dopamine precursor availability (pDAP) at baseline as an estimate for central dopamine levels. The HFS group had a significantly higher pDAP at baseline compared...

show abstract

Dorsal Striatal Dopamine, Food Preference and Health Perception in Humans

Cited by 21 publications

References 30 publications

Dopamine Synthesis Capacity is Associated with D2/3 Receptor Binding but Not Dopamine Release

Dopamine Synthesis Capacity is Associated with D2/3 Receptor Binding but Not Dopamine Release

Genotype status of the dopamine-related catechol-O-methyltransferase (COMT) gene corresponds with desirability of “unhealthy” foods

Differences in intake of high-fat high-sugar diet are related to variations in central dopamine in humans

Contact Info

Product

Resources

About