Dorsal Root Ganglion Stimulation for Chronic Groin Pain: A Review

Char, Steven; Barman, Ross; Deer, Timothy R; Hagedorn, Jonathan M

doi:10.1111/ner.13468

Cited by 3 publications

(3 citation statements)

References 38 publications

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“…Total knee arthroplasty (TKA) is one of the most common surgeries with over 700,000 performed in the USA annually. Unfortunately, 8–34% of post-TKA patients experience a complicated postsurgical course with persistent neuropathic postsurgical pain (NPP) [ 66 , 67 ]. DRG-S may offer a viable treatment modality for patients with persistent neuropathic knee pain refractory to conventional medical management.…”

Section: Resultsmentioning

confidence: 99%

“…Advantages of DRG-S over dorsal column SCS include targeting discrete areas, maintenance of efficacy with postural changes, and lack of paresthesia in non-targeted areas [6]. These unique features of DRGS posit it to be especially useful in post-herniorrhaphy groin pain, a notoriously challenging region to target via dorsal column SCS [65][66][67]. Inguinal hernia repair is a common procedure, and the literature suggests that between 5% and 25% of patients will manifest post-herniorrhaphy neuralgia [65,68].…”

Section: Groin Painmentioning

confidence: 99%

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Dorsal Root Ganglion Stimulation for Lower Extremity Neuropathic Pain Syndromes: An Evidence-Based Literature Review

et al. 2022

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Dorsal root ganglion stimulation (DRG-S) is a form of selective neuromodulation therapy that targets the dorsal root ganglion. DRG-S offers analgesia in a variety of chronic pain conditions and is approved for treatment of complex regional pain syndrome (CRPS) by the US Food and Drug Administration (FDA). There has been increasing utilization of DRG-S to treat various neuropathic pain syndromes of the lower extremity, although evidence remains limited to one randomized controlled trial and 39 observational studies. In this review, we appraised the current evidence for DRG-S in the treatment of lower extremity neuropathic pain using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) criteria. The primary outcome was change in pain intensity after DRG-S compared to baseline. We stratified presentation of results based of type of neuropathy (CRPS, painful diabetic neuropathy, mononeuropathy, polyneuropathy) as well as location of neuropathy (hip, knee, foot). Future powered randomized controlled trials with homogeneous participants are warranted.

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Section: Resultsmentioning

confidence: 99%

Section: Groin Painmentioning

confidence: 99%

Dorsal Root Ganglion Stimulation for Lower Extremity Neuropathic Pain Syndromes: An Evidence-Based Literature Review

et al. 2022

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“…[9][10][11] The neurons located within the DRG are responsible for sensory transduction and modulation from the periphery, including pain perception. [12][13][14][15] Epigenetic mechanisms, strongly affecting the regulation of gene expression, have been associated with pathophysiological pain. [16][17][18][19][20][21] Inhibiting DNA methylation prevents and reverses pain behaviors, suggesting a potential role of DNA demethylation in pain.…”

Section: Introductionmentioning

confidence: 99%

Increased ten-eleven translocation methylcytosine dioxygenase one in dorsal root ganglion contributes to inflammatory pain in CFA rats

Liu¹,

Zhang²,

Xu³

et al. 2022

Mol Pain

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DNA hydroxylation catalyzed by Tet dioxygenases occurs abundantly in neurons in mammals. However, effects of ten-eleven translocation methylcytosine dioxygenase 1 (TET1) expression and hydroxymethylation status on neuron injury remain unclear. This study was designed to explore the effects of TET1 and TET2 expression in the inflammatory pain of rats induced by complete Freund's adjuvant (CFA). Mechanical paw withdrawal threshold (PWT) and thermal withdrawal latency (TWL) were detected to assess pain behavior. The expression of TET1 and TET2 were measured in the dorsal root ganglion (DRG) with western blotting analysis. Immunofluorescence staining is employed to detect the expression and co-location of TRPV1 with TET1. Intrathecal administration of Bobcat339 was used to inhibit TET1 function in DRG. The PWT and TWL of rats were significantly reduced after CFA Injection. Western blot results showed that the expression of TET1 was significantly increased at 3 d after CFA injection, but TET2 had no statistical difference. Immunofluorescence results showed that TET1 was co-localized with TRPV1. Intrathecal administration of Bobcat339 improved mechanical and thermal pain threshold in CFA rats. Our findings highlight the role of TET1 in chronic inflammatory pain model. The expression of TET1 was increased in CFA rats, and suppression of TET1 will ameliorate inflammatory pain.

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Prediction of cell-cell communication patterns of dorsal root ganglion cells: single-cell RNA sequencing data analysis

Lian,

Wu,

Liu

et al. 2023

Neural Regeneration Research

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Dorsal root ganglion neurons transmit peripheral somatic information to the central nervous system, and dorsal root ganglion neuron excitability affects pain perception. Dorsal root ganglion stimulation is a new approach for managing pain sensation. Knowledge of the cell-cell communication among dorsal root ganglion cells may help in the development of new pain and itch management strategies. Here, we used the single-cell RNA-sequencing (scRNA-seq) database to investigate intercellular communication networks among dorsal root ganglion cells. We collected scRNA-seq data from six samples from three studies, yielding data on a total of 17,766 cells. Based on genetic profiles, we identified satellite glial cells, Schwann cells, neurons, vascular endothelial cells, immune cells, fibroblasts, and vascular smooth muscle cells. Further analysis revealed that eight types of dorsal root ganglion neurons mediated proprioceptive, itch, touch, mechanical, heat, and cold sensations. Moreover, we predicted several distinct forms of intercellular communication among dorsal root ganglion cells, including cell-cell contact, secreted signals, extracellular matrix, and neurotransmitter-mediated signals. The data mining predicted that Mrgpra3-positive neurons robustly express the genes encoding the adenosine Adora2b (A2B) receptor and glial cell line-derived neurotrophic factor family receptor alpha 1 (GFRa-1). Our immunohistochemistry results confirmed the coexpression of the A2B receptor and GFRa-1. Intrathecal injection of the A2B receptor antagonist PSB-603 effectively prevented histamine-induced scratching behaviour in a dose-dependent manner. Our results demonstrate the involvement of the A2B receptor in the modulation of itch sensation. Furthermore, our findings provide insight into dorsal root ganglion cell-cell communication patterns and mechanisms. Our results should contribute to the development of new strategies for the regulation of dorsal root ganglion excitability.

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Dorsal Root Ganglion Stimulation for Chronic Groin Pain: A Review

Cited by 3 publications

References 38 publications

Dorsal Root Ganglion Stimulation for Lower Extremity Neuropathic Pain Syndromes: An Evidence-Based Literature Review

Dorsal Root Ganglion Stimulation for Lower Extremity Neuropathic Pain Syndromes: An Evidence-Based Literature Review

Increased ten-eleven translocation methylcytosine dioxygenase one in dorsal root ganglion contributes to inflammatory pain in CFA rats

Prediction of cell-cell communication patterns of dorsal root ganglion cells: single-cell RNA sequencing data analysis

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