Dorsal Radial Glial Cells Have the Potential to Generate Cortical Interneurons in Human But Not in Mouse Brain

Yu, Xiuli; Zečević, Nada

doi:10.1523/jneurosci.5249-10.2011

Cited by 71 publications

(68 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, interneurons expressing tyrosine hydroxylase appear to be particularly abundant in deep layers of human neocortex relative to other mammalian species (Defelipe 2011). Variation in GABAergic neuron subtype proportions between human and mouse neocortex has also been attributed to species' differences in the neuroanatomical origins of these cells (Letinic et al 2002;Jakovcevski et al 2011;Yu and Zecevic 2011;Radonjic et al 2014a), although this interpretation is not universally accepted (Hansen et al 2013;Ma et al 2013). Our finding of molecular differences in SCGN activity between humans and mice provides further support for efforts to clarify species' differences among subpopulations of GABAergic neurons.…”

Section: Discussionmentioning

confidence: 99%

Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity

et al. 2017

View full text Add to dashboard Cite

The neocortex of primates, including humans, contains more abundant and diverse inhibitory neurons compared with rodents, but the molecular foundations of these observations are unknown. Through integrative gene coexpression analysis, we determined a consensus transcriptional profile of GABAergic neurons in mid-gestation human neocortex. By comparing this profile to genes expressed in GABAergic neurons purified from neonatal mouse neocortex, we identified conserved and distinct aspects of gene expression in these cells between the species. We show here that the calcium-binding protein secretagogin (SCGN) is robustly expressed by neocortical GABAergic neurons derived from caudal ganglionic eminences (CGE) and lateral ganglionic eminences during human but not mouse brain development. Through electrophysiological and morphometric analyses, we examined the effects of SCGN expression on GABAergic neuron function and form. Forced expression of SCGN in CGE-derived mouse GABAergic neurons significantly increased total neurite length and arbor complexity following transplantation into mouse neocortex, revealing a molecular pathway that contributes to morphological differences in these cells between rodents and primates.

show abstract

Section: Discussionmentioning

confidence: 99%

Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Recently, it has been shown that chemokine signaling involving C-X-C motif ligand 12 (CXCL12) and its receptors CXCR4 and CXCR7 regulates the tangential migratory stream of interneurons (Sessa et al, 2010;Sánchez-Alcañiz et al, 2011;Wang et al, 2011). Although it has been suggested that some interneurons are derived from dorsal progenitors in the human fetal neocortex (Letinic et al, 2002;Yu and Zecevic, 2011), certain human interneuron subtypes are probably generated in the ventral telencephalon and enter the cortex via tangential migration (Fertuzinhos et al, 2009). Upon arrival in the neocortex, interneurons migrate radially to enter the CP (Nadarajah and Parnavelas, 2002;Ang et al, 2003;Yokota et al, 2007a) Prior to the onset of neurogenesis, neural progenitors (NPs) in the ventricular zone (VZ; blue) of the developing neocortex divide symmetrically to expand the progenitor pool, undergoing interkinetic nuclear migration (IKNM) as they progress through the cell cycle.…”

Section: Generation and Migration Of Neocortical Inhibitory Interneuronsmentioning

confidence: 99%

Transcriptional co-regulation of neuronal migration and laminar identity in the neocortex

2012

View full text Add to dashboard Cite

The cerebral neocortex is segregated into six horizontal layers, each containing unique populations of molecularly and functionally distinct excitatory projection (pyramidal) neurons and inhibitory interneurons. Development of the neocortex requires the orchestrated execution of a series of crucial processes, including the migration of young neurons into appropriate positions within the nascent neocortex, and the acquisition of layer-specific neuronal identities and axonal projections. Here, we discuss emerging evidence supporting the notion that the migration and final laminar positioning of cortical neurons are also co-regulated by cell type-and layerspecific transcription factors that play concomitant roles in determining the molecular identity and axonal connectivity of these neurons. These transcriptional programs thus provide direct links between the mechanisms controlling the laminar position and identity of cortical neurons. Key words: Neuronal specification, Neuronal migration, Neuronal identity, Axon pathfinding, Pyramidal neuron, Neuronal circuits, Cerebral cortex IntroductionThe cerebral cortex, an extensive sheet of neural tissue at the most superficial part of the cerebral hemispheres, is involved in a variety of higher cognitive, emotional, sensory and motor functions. The emergence of a six-layered neocortex, the phylogenetically most recent part of the cerebral cortex, and its extensive projections to subcortical regions are key features of mammalian evolution. The ability of the neocortex to mediate complex cognitive and motor tasks depends on the accurate execution of molecular processes that control the identity and positioning of neurons and the formation of their precise synaptic connections during development. The incorrect formation of neocortical organization and circuitry might lead to cognitive impairments and increased susceptibility to major psychiatric and neurological disorders (Valiente and Marín, 2010;Liu, 2011;Manzini and Walsh, 2011;Rubenstein, 2011).The neocortex is composed of six horizontal layers (L1-L6; see Glossary, Box 1) that are cytoarchitectonically and functionally distinct. Each layer contains a unique subset of neurons ( Fig. 1), including glutamatergic excitatory projection (pyramidal) neurons (see Glossary, Box 1) and GABAergic inhibitory interneurons (see Glossary, Box 1) (Jones, 1986;DeFelipe and Farinas, 1992). Furthermore, the projection neurons of L2-L6 exhibit marked layerand subtype-specific differences in their molecular expression and axon projections (DeFelipe and Farinas, 1992;O'Leary and Koester, 1993;Molyneaux et al., 2007). For example, corticofugal axons targeting subcortical structures arise solely from deep-layer (L5 and L6) and subplate (SP; see Glossary, Box 1) neurons, whereas upper-layer (L2-L4) neurons project within the cortex, either intra-hemispherically or contralaterally, mostly via the corpus callosum (see Glossary, Box 1). In addition to projection neurons, interneurons of distinct lineages and morphological, neurochemical and electro...

show abstract

“…Recently, studies have shown that in non-human primate, interneurons use a similar coding of transcription factors as in rodents and largely originate from the ganglionic eminences [93] (Figure 3C). However, a substantial proportion of them is likely to be generated in the pallium from the VZ and the SVZ [12,[94][95][96] (Figure 3C). Recently, migration of subclasses of human cortical interneurons has been reported to continue after birth [97].…”

Section: Serotonin -A Chemical Messenger Between All Types Of Living mentioning

confidence: 99%

Sculpting Cerebral Cortex with Serotonin in Rodent and Primate

Vitalis¹,

Verney²

2017

Serotonin - A Chemical Messenger Between All Types of Living Cells

View full text Add to dashboard Cite

The mammalian cerebral cortex is critical for sensory and motor integrations and, for higher-order cognitive functions. The construction of mammalian cortical circuits involves the coordinated interplay between cellular processes such as proliferation, migration and differentiation of neural and glial cell subtypes followed by accurate connectivity evolving in complexity in primates. Alteration in cortical development may induce the emergence of various pathological traits and behaviours. Among the large array of factors that regulate the assembly of cortical circuits, serotonin (5-HT) plays important role as a developmental signal that impacts on a broad diversity of cellular processes. 5-HT plays distinct roles during specific sensitive periods and is produced from various sources depending on the perinatal stage. Its roles are mediated by more than fourteen 5-HT receptors that are all G-protein coupled receptors except the ionotropic 5-HT type 3A receptor (5-HT 3A ) mediating rapid neuronal activation. Importantly, 5-HT metabolism and signalling are influenced by numerous epigenetic and genetic factors, including nutrition and gut microbiota, perinatal stress, infection and inflammation. In this review, we will recapitulate some evidences showing that dysregulation of 5-HT homeostasis and 5-HT 3A signalling impairs distinct steps of cortical circuit formation leading to the predisposition of the onset of various psychiatric diseases.

show abstract

Dorsal Radial Glial Cells Have the Potential to Generate Cortical Interneurons in Human But Not in Mouse Brain

Cited by 71 publications

References 56 publications

Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity

Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity

Transcriptional co-regulation of neuronal migration and laminar identity in the neocortex

Sculpting Cerebral Cortex with Serotonin in Rodent and Primate

Contact Info

Product

Resources

About