DORMEX^® -hydrogen cyanamide poisoning

Abstract

Case reports of acute and chronic exposure to hydrogen cyanamide (DORMEX®) have been reported but mainly as a result of occupational or accidental exposure and without any mortality. We report a case of acute hydrogen cyanamide poisoning in a young male due to suicidal intent. The patient was managed under intensive care with all the standard protocols for detoxification. However, in spite of aggressive management, patient could not be rescued. An extensive literature search did not yield any similar case reports. Hence, we report this case to the medical community to be aware of the entity.

The MADS-Box Gene MdDAM1 Controls Growth Cessation and Bud Dormancy in Apple

“…In contrast, climate warming in Southern Europe affect the chilling requirements with a direct impact on bud break and flowering periods (Legave et al, 2013). The use of toxic chemicals such as hydrogen cyanamide is often the last resort for fruit growers to artificially break dormancy but with adverse effects on human health and on the environment (Sheshadri et al, 2011).…”

Unveiling the Deadly Effects of Hydrogen Cyanamide Poisoning: A Case Report

“…Hypotension and shock are early symptoms observed in these patients, with a reported occurrence of 50% according to Gamaluddin H [5] . Sheshadri SH et al [12] proposed that this phenomenon may be attributed to a vasodilatory effect caused by nitro, resulting from the oxidation of hydrogen cyanamide by catalase. It is noteworthy that hydrogen cyanamide is also an aldehyde dehydrogenase inhibitor, potentially leading to a severe cyanamide-ethanol reaction if the patient concurrently consumes a large quantity of alcohol, thereby exacerbating the shock [13] .…”

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“…The need for the use of HC by fruit growers is predicted to increase with the effects of climate change and a general warming of growing regions [13]. HC is toxic, and its use has either already been banned or is predicted to be banned in several countries [14]. This is especially concerning as markets are sensitive, emphasizing the importance of looking for environmentally friendly production practices for grape products.…”