Dormant phages communicate via arbitrium to control exit from lysogeny

Aframian, Nitzan; Bendori, Shira Omer; Kabel, Stav; Guler, Polina; Stokar-Avihail, Avigail; Manor, Erica; Msaeed, kholod; Lipsman, Valeria; Grinberg, Ilana; Mahagna, Alaa; Eldar, Avigdor

doi:10.1038/s41564-021-01008-5

Cited by 32 publications

(31 citation statements)

References 41 publications

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“…Consistent with this idea, several molecules were identified as triggers (inducing agents) for (soil) temperate phages to enter the lytic cycle, some of which indicate a coupling between host cell and/or prophage densities and viral replication [81][82][83][84]. Pseudolysogeny, that is, the maintenance of a phage genome in a host cell in a 'stalled' infection state, may represent another avenue for viral persistence in soil [19,84].…”

Section: Trends In Microbiologymentioning

confidence: 85%

Diversity in the soil virosphere: to infinity and beyond?

Roux

Emerson

2022

Trends in Microbiology

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Section: Trends In Microbiologymentioning

confidence: 85%

Diversity in the soil virosphere: to infinity and beyond?

Roux

Emerson

2022

Trends in Microbiology

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“…However, the induction of prophage leading to the reinitiation of the lytic pathway would become especially relevant in the long term. Recent work shows that communicating phage restarts lysis via arbitrium induction, preventing spontaneous induction via DNA damage ( Aframian 2022 ) and triggering prophage induction when signal concentrations decline, potentially indicating the presence of new susceptible hosts nearby ( Bruce et al. 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Timescales modulate optimal lysis–lysogeny decision switches and near-term phage reproduction

Shivam¹,

Lucía-Sanz

et al. 2022

Virus Evolution

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Temperate phage can initiate lysis or lysogeny after infecting a bacterial host. The genetic switch between lysis and lysogeny is mediated by phage regulatory genes as well as host and environmental factors. Recently, a new class of decision switches was identified in phage of the SPbeta group, mediated by the extracellular release of small, phage-encoded peptides termed arbitrium. Arbitrium peptides can be taken up by bacteria prior to infection, modulating the decision switch in the event of a subsequent phage infection. Increasing concentration of arbitrium increases the chance that a phage infection will lead to lysogeny, rather than lysis. Although prior work has centered on the molecular mechanisms of arbitrium-induced switching, here we focus on how selective pressures impact the benefits of plasticity in switching responses. In this work, we examine the possible advantages of near-term adaptation of communication-based decision switches used by the SPbeta-like group. We combine a nonlinear population model with a control theoretic approach to evaluate the relationship between a putative phage reaction norm (i.e., the probability of lysogeny as a function of arbitrium) and the extent of phage reproduction at a near-term time horizon. We measure phage reproduction in terms of a cellular-level metric previously shown to enable comparisons of near-term phage fitness across a continuum from lysis to latency. We show the adaptive potential of communication-based lysis-lysogeny responses and find that optimal switching between lysis to lysogeny increases near-term phage reproduction compared to fixed responses, further supporting both molecular and model-based analyses of the putative benefits of this class of decision switches. We further find that plastic responses are robust to the inclusion of cellular-level stochasticity, variation in life history traits, and variation in resource availability. These findings provide further support to explore the long-term evolution of plastic decision systems mediated by extracellular decision-signaling molecules, and the feedback between phage reaction norms and ecological context.

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“…The peptides, referred to as arbitrium signals, were found to be phage-specific in many cases, presumably limiting cross-talk between the systems of different infecting phages. Subsequent studies went on to show that prophages continue to communicate via the arbitrium system after integration and that both the entry and exit from lysogeny are influenced by these dynamics [ 150 ]. Interestingly, both arbitrium-mediated communication and lysis inhibition can be viewed as signals sent from previously infected to currently infected cells that can be used to assess extracellular conditions and guide phage infection strategy.…”

Section: Ecological Complexitymentioning

confidence: 99%

Viral Complexity

Aylward

Moniruzzaman

2022

Biomolecules

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Although traditionally viewed as streamlined and simple, discoveries over the last century have revealed that viruses can exhibit surprisingly complex physical structures, genomic organization, ecological interactions, and evolutionary histories. Viruses can have physical dimensions and genome lengths that exceed many cellular lineages, and their infection strategies can involve a remarkable level of physiological remodeling of their host cells. Virus–virus communication and widespread forms of hyperparasitism have been shown to be common in the virosphere, demonstrating that dynamic ecological interactions often shape their success. And the evolutionary histories of viruses are often fraught with complexities, with chimeric genomes including genes derived from numerous distinct sources or evolved de novo. Here we will discuss many aspects of this viral complexity, with particular emphasis on large DNA viruses, and provide an outlook for future research.

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Dormant phages communicate via arbitrium to control exit from lysogeny

Cited by 32 publications

References 41 publications

Diversity in the soil virosphere: to infinity and beyond?

Diversity in the soil virosphere: to infinity and beyond?

Timescales modulate optimal lysis–lysogeny decision switches and near-term phage reproduction

Viral Complexity

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