Dormancy in cancer metastasis: keys to moving forward

Welch, Danny R.

doi:10.1007/s10555-023-10083-5

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…These processes involve a number of cellular mechanisms led by cytoskeleton dynamics, as well as molecular changes such as the production of adhesion and proteolytic enzymes [28,29]. An altered expression of cell adhesion molecules, including cadherins and integrins, can enhance tumor cell adhesion to the extracellular matrix (ECM), thus promoting invasion and metastasis [30,31].…”

Section: Introductionmentioning

confidence: 99%

A Regulator Role for the ATP-Binding Cassette Subfamily C Member 6 Transporter in HepG2 Cells: Effect on the Dynamics of Cell–Cell and Cell–Matrix Interactions

Matera,

Miglionico,

Abruzzese

et al. 2023

IJMS

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There is growing evidence that various ATP-binding cassette (ABC) transporters contribute to the growth and development of tumors, but relatively little is known about how the ABC transporter family behaves in hepatocellular carcinoma (HCC), one of the most common cancers worldwide. Cellular model studies have shown that ABCC6, which belongs to the ABC subfamily C (ABCC), plays a role in the cytoskeleton rearrangement and migration of HepG2 hepatocarcinoma cells, thus highlighting its role in cancer biology. Deep knowledge on the molecular mechanisms underlying the observed results could provide therapeutic insights into the tumors in which ABCC6 is modulated. In this study, differential expression levels of mRNA transcripts between ABCC6-silenced HepG2 and control groups were measured, and subsequently, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed. Real-Time PCR and Western blot analyses confirmed bioinformatics; functional studies support the molecular mechanisms underlying the observed effects. The results provide valuable information on the dysregulation of fundamental cellular processes, such as the focal adhesion pathway, which allowed us to obtain detailed information on the active role that the down-regulation of ABCC6 could play in the biology of liver tumors, as it is involved not only in cell migration but also in cell adhesion and invasion.

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Section: Introductionmentioning

confidence: 99%

A Regulator Role for the ATP-Binding Cassette Subfamily C Member 6 Transporter in HepG2 Cells: Effect on the Dynamics of Cell–Cell and Cell–Matrix Interactions

Matera,

Miglionico,

Abruzzese

et al. 2023

IJMS

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A Senescence-Associated Secretory Phenotype of Bone Marrow Mesenchymal Stem Cells Inhibits the Viability of Breast Cancer Cells

Li,

Liu,

et al. 2024

Stem Cell Rev and Rep

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Nomograms to Predict Individual Potential Benefit from Targeted Therapy for patients with lymph node positive Luminal B (HER2-) breast cancer

Yue,

Meng,

et al. 2024

Preprint

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Purpose To construct nomograms combining clinicopathological characteristics, bone metastases (BM), viscera metastases (VM) and cancer-related deaths (CRD) to predict the higher-risk patients with lymph node positive (N+) Luminal B (HER2-) breast cancer (BC). Method Kaplan-Meier survival analysis, Venn diagram, Bar charts were used to describe the data for subsequent metastasis and CRD. Thirty-six clinicopathological characteristics were extracted in univariate and multivariate Cox regression analyses to develop nomogram to predict potential risk of BM, VM and CRD among patients with N+ Luminal B (HER2-) BC. The calibration plots, concordance index and receiver operating characteristics (ROC) analysis were applied to determine the nomogram accuracy. Result The median age of 8139 patients was 51 years, with a median follow-up of 124 months (4–216 months). There was no statistical difference between the metachronous primary bilateral BC and synchronous primary bilateral BC. The number-peak period of patients with subsequent BM was the third year, VM was the 4th year and CRD was the 6th year (range second–6th year, 4th–6th year and third–8th year, respectively). BM, VM and CRD nomograms showed outstanding performance and discriminative ability (C-index 0.69, 0.68 and 0.71, respectively). The calibration curves and ROC curves analysis demonstrated the considerable clinical usefulness of the combined nomogram. Three clinical examples showed results differences in optimal period who had similar pathological stage. Conclusion The developed nomogram model consisting of time-event-dependent clinicopathological characteristics could reliable in predicting BM, VM and CRD probability of patients with N+ Luminal B (HER2-) BC.

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Dormancy in cancer metastasis: keys to moving forward

Cited by 3 publications

References 7 publications

A Regulator Role for the ATP-Binding Cassette Subfamily C Member 6 Transporter in HepG2 Cells: Effect on the Dynamics of Cell–Cell and Cell–Matrix Interactions

A Regulator Role for the ATP-Binding Cassette Subfamily C Member 6 Transporter in HepG2 Cells: Effect on the Dynamics of Cell–Cell and Cell–Matrix Interactions

A Senescence-Associated Secretory Phenotype of Bone Marrow Mesenchymal Stem Cells Inhibits the Viability of Breast Cancer Cells

Nomograms to Predict Individual Potential Benefit from Targeted Therapy for patients with lymph node positive Luminal B (HER2-) breast cancer

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