DOR-1, A novel CD10+ stromal cell line derived from progressive Langerhans cell histiocytosis of bone

Gogusev, Jean; Telvi, Louise; Murakami, Ichiro; Lepelletier, Yves; Nézelof, C; Stojkoski, Alexandre; Glorion, Christophe; Jaubert, Françis

doi:10.1002/pbc.20090

Cited by 8 publications

(13 citation statements)

References 35 publications

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“…However, to our knowledge no investigator has been able to propagate these cells in vitro for more than a few days, nor has successful maintenance of LCH cells in immune‐deficient mice been claimed (79). The only reported attempt in this direction is the generation of the DOR‐1 cell line established from a pediatric bone lesion LCH (80). However, as the authors state, the cellular origin of this cell line is probably not an LCH cell, as DOR‐1 cells lack the typical features of LCH cells, such as CD1a, Langerin, and HLA‐DR expression.…”

Section: Are Lch Cells Intrinsically Aberrant?mentioning

confidence: 99%

Langerhans cell histiocytosis: fascinating dynamics of the dendritic cell–macrophage lineage

Egeler

Halteren

Hogendoorn

et al. 2010

Immunological Reviews

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In its rare occurrence, Langerhans cell histiocytosis (LCH) is a dangerous but intriguing deviation of mononuclear phagocytes, especially dendritic cells (DCs). Clinically, the disease ranges from self-resolving or well manageable to severe and even fatal. LCH lesions in skin, bone, and other sites contain high numbers of cells with phenotypic features resembling LCs admixed with macrophages, T cells, eosinophils, and multinucleated giant cells. Here we review current progress in the LCH field based on two central questions: (i) are LCH cells intrinsically aberrant, and (ii) how does the lesion drive pathogenesis? We argue that LCH cells may originate from different sources, including epidermal LCs, tissue Langerin(+) DCs, or mononuclear phagocyte precursors. Current and prospective in vitro and in vivo models are discussed. Finally, we discuss recent insights into plasticity of T-helper cell subsets in light of the lesion microenvironment. LCH continues to provide urgent clinical questions thereby inspiring innovative DC lineage research.

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Section: Are Lch Cells Intrinsically Aberrant?mentioning

confidence: 99%

Langerhans cell histiocytosis: fascinating dynamics of the dendritic cell–macrophage lineage

Egeler

Halteren

Hogendoorn

et al. 2010

Immunological Reviews

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“…Recent reports pointed out the expression of CD10 in the bone involvement of various inflammatory and tumoral lesions 6 . Because joint destruction is a characteristic feature of MRH (Fig.…”

Section: Expression Of Cd10 In Multinucleated Giant Cellsmentioning

confidence: 99%

“…Recent reports pointed out the expression of CD10 in the bone involvement of various inflammatory and tumoral lesions. 6 Because joint destruction is a characteristic feature of MRH ( Fig. 1a), we decided to investigate the expression of CD10 in MRH in comparison with other histiocytic lesions manifesting giant cells in skin and synovial lesions such as giant-cell tendon sheath tumor, granuloma annulare, ruptured epidermoid cyst, sarcoidosis, xanthogranuloma, pigmented villonodular synovitis and rheumatoid arthritis.…”

mentioning

confidence: 99%

Aberrant expression of CD10 in ground‐glass‐like multinucleated giant cells of multicentric reticulohistiocytosis

Tashiro

Takeuchi

Nakahara

et al. 2010

The Journal of Dermatology

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“…Attempts have been made to culture pathologic LCs with the intention of using them in a xenotransplantation model. However, the one report of a cell line that grew from a CD1a + LCH bone lesion describes the cells as CD1a -and Langerin -, indicating that they are not pathologic LCs (Gogusev et al, 2005). Another group used HeLa cells that were engineered to express CD1a as a model for testing the diagnostic and therapeutic efficacy of derivatized anti-CD1a antibodies (Murray et al, 2000).…”

Section: Modelsmentioning

confidence: 99%

Langerhans cell histiocytosis: malignancy or inflammatory disorder doing a great job of imitating one?

Degar

Rollins

2009

Disease Models &Amp; Mechanisms

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Langerhans cell histiocytosis (LCH) is the unifying designation for a rare proliferative disorder that occurs predominantly in childhood and involves the main antigen-presenting cell of the epidermis. LCH can present in a multitude of ways, from a self-limited rash that resolves spontaneously to a systemic multi-organ disease with a 20% mortality rate. Because some forms behave in a relatively benign manner and are associated with an inflammatory cell infiltrate, it has been proposed that LCH might be a reactive disease. However, its neoplastic nature is suggested by the fact that the proliferating cells in LCH are clonal and overexpress p53. Nonetheless, no recurrent genomic, genetic or epigenetic abnormalities have been identified. Instead, a variety of molecular abnormalities that are consistent with disordered Langerhans cell maturation have been described. A faithful small animal model would aid our understanding of the pathophysiology of LCH but, to date, none exists. Challenges to the creation of a model include the lack of characteristically recurrent genetic abnormalities and the absence of a truly tissue-specific promoter to drive expression of genetic elements solely in Langerhans cells. Still, some of the phenotypic abnormalities in adhesion molecule or chemokine receptor expression might be modeled with sufficient precision to allow the testing of novel therapies.

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DOR-1, A novel CD10+ stromal cell line derived from progressive Langerhans cell histiocytosis of bone

Abstract: The DOR-1 cell line exhibits distinct immuno-cytochemical features and carries the t (9; 17) (p23; p13) translocation suggesting involvement of stromal-like cell lineage in LCH initiation and progression.

Cited by 8 publications

References 35 publications

Langerhans cell histiocytosis: fascinating dynamics of the dendritic cell–macrophage lineage

Langerhans cell histiocytosis: fascinating dynamics of the dendritic cell–macrophage lineage

Aberrant expression of CD10 in ground‐glass‐like multinucleated giant cells of multicentric reticulohistiocytosis

Langerhans cell histiocytosis: malignancy or inflammatory disorder doing a great job of imitating one?

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