Dopplersonographic measurement of global cerebral circulation time using echo contrast-enhanced ultrasound in normal individuals and patients with arteriovenous malformations

Schreiber, Stephan J.; Franke, Uwe; Doepp, Florian; Staccioli, Elda; Uludağ, Kâmil; Valdueza, José M.

doi:10.1016/s0301-5629(02)00477-5

Cited by 35 publications

(44 citation statements)

References 18 publications

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“…Despite different technical approaches used, mean CCT values were within a narrow range of 5.6 ± 1.7 to 7.0 ± 1.3 seconds (own data: 6.3 ± 1.2 seconds) for Dopplersonographic and 7.5 ± 1.1 second for duplexsonographic techniques, corresponding well with historic angiographically determined CCTs of 4.9 to 5.6 seconds (Gilroy et al, 1963). In our study, the approach reported by Schreiber et al (2002) was used. The authors described three different mathematical CCT definitions, of which the CCT 2 , defined as the time interval between the turning points of the ICA and internal jugular vein timeintensity curves, yielded the lowest variabilities and best reproducibility results (Schreiber et al, 2002).…”

Section: Figmentioning

confidence: 99%

“…Reported mean CBF in the ultrasound studies ranged from 567 ± 125 (Dörfler et al, 2000) to 727 ± 102 mL/min (Scheel et al, 2000) depending on the investigated age groups, while we found a mean CBF of 733 ± 99 mL/min. Ultrasonographic measurement of global CCT has recently been demonstrated in healthy volunteers (Hoffmann et al, 2000;Schreiber et al, 2002Schreiber et al, , 2003. Despite different technical approaches used, mean CCT values were within a narrow range of 5.6 ± 1.7 to 7.0 ± 1.3 seconds (own data: 6.3 ± 1.2 seconds) for Dopplersonographic and 7.5 ± 1.1 second for duplexsonographic techniques, corresponding well with historic angiographically determined CCTs of 4.9 to 5.6 seconds (Gilroy et al, 1963).…”

Section: Figmentioning

confidence: 99%

“…CCT analysis was performed immediately after CBF measurements without changing the subject's body position using a previously described Dopplersonographic approach (Schreiber et al, 2002). In brief, two pulsed 2-MHz Doppler probes of a dual-channel Doppler system (TCD X4, DWL, Sipplingen, Germany) were used for continuous extracranial signal detection of the dominant internal jugular vein and the contralateral ICA.…”

Section: Ultrasound Setupmentioning

confidence: 99%

“…Then, a 4-mL Levovist bolus (300 mg/mL, Schering AG, Berlin, Germany) was injected into a cubital vein using an infusion pump with an injection speed of 3 mL/s (Medrad Pulsar, Indianola, PA, U.S.A.). Bolus arrival in the ICA and internal jugular vein was monitored and the time interval between the turning points of a fitted time-intensity curve was defined as the global CCT (corresponding to CCT 2 in Schreiber et al, 2002).…”

Section: Ultrasound Setupmentioning

confidence: 99%

“…Applied to both internal carotid arteries (ICA) and vertebral arteries (VA), this technique measures global cerebral blood flow volume (CBF), which has been shown to be a precise and reliable approach (Dörfler et al, 2000;Scheel et al, 2000;Schöning and Scheel, 1996;Schöning et al, 1994). Recently, an ultrasonographic technique for the assessment of a global cerebral circulation time (CCT) in healthy volunteers was described (Hoffmann et al, 2000;Schreiber et al, 2002Schreiber et al, , 2003. The authors used an echocontrast bolus tracking method, analyzing the time interval of a Levovist®-bolus arrival between the distal extracranial ICA and the dominant internal jugular vein.…”

mentioning

confidence: 99%

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Ultrasonographic Assessment of Global Cerebral Blood Volume in Healthy Adults

Doepp

Schreiber

Brunecker

et al. 2003

J Cereb Blood Flow Metab

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Summary:The authors describe a new ultrasonographic method for analysis of global cerebral blood volume (CBV) and its application under controlled hyperventilation. CBV was determined as the product of global cerebral blood flow volume (CBF) and global cerebral circulation time. CBF was measured by duplex sonography and calculated as the sum of flow volumes in both internal carotid arteries and vertebral arteries. Extracranial Doppler assessed cerebral circulation time by determining the time interval of echo-contrast bolus arrival between internal carotid artery and contralateral internal jugular vein. Forty-four healthy volunteers (mean age 45 ± 19 years, range 20-79 years) were studied. Mean CBV was 77 ± 13 mL.

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Section: Figmentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

Section: Ultrasound Setupmentioning

confidence: 99%

Section: Ultrasound Setupmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Ultrasonographic Assessment of Global Cerebral Blood Volume in Healthy Adults

Doepp

Schreiber

Brunecker

et al. 2003

J Cereb Blood Flow Metab

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Tracking cerebral blood flow in BOLD fMRI using recursively generated regressors

Tong

Frederick

2014

Human Brain Mapping

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BOLD fMRI data is dominated by low frequency signals, many of them of unclear origin. We have recently shown that some portion of the low frequency oscillations found in BOLD fMRI are systemic signals closely related to the blood circulation (Tong, et al., 2013). They are commonly treated as physiological noise in fMRI studies. In the present study, we propose and test a novel data-driven analytical method that uses these systemic low frequency oscillations in the BOLD signal as a tracer to follow cerebral blood flow dynamically. Our findings demonstrate that: (1) systemic oscillations pervade the BOLD signal; (2) the temporal traces evolve as the blood propagates though the brain; and, (3) they can be effectively extracted via a recursive procedure and used to derive the cerebral circulation map. Moreover, this method is independent from functional analyses, and thus allows simultaneous and independent assessment of information about cerebral blood flow to be conducted in parallel with the functional studies. In this study, the method was applied to data from the resting state scans, acquired using a multiband EPI sequence (fMRI scan with much shorter TRs), of 7 healthy participants. Dynamic maps with consistent features resembling cerebral blood circulation were derived, confirming the robustness and repeatability of the method.

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Cerebral circulation time derived from fMRI signals in large blood vessels

Yao

Wang

Yang

et al. 2019

Magnetic Resonance Imaging

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Background The systemic low‐frequency oscillation (sLFO) functional (f)MRI signals extracted from the internal carotid artery (ICA) and the superior sagittal sinus (SSS) are found to have valuable physiological information. Purpose 1) To further develop and validate a method utilizing these signals to measure the delay times from the ICAs and the SSS. 2) To establish the delay time as an effective perfusion biomarker that associates with cerebral circulation time (CCT). 3) To explore within subject variations, and the effects of gender and age on the delay times. Study Type Prospective. Subjects In all, 100 healthy adults (Human Connectome Project [HCP], age range 22–36 years, 54 females and 46 males), 56 healthy children (Adolescent Brain Cognitive Development project) were included. Field Strength/Sequence Echo planar imaging (EPI) sequence at 3T. Assessment The sLFO fMRI signals from the ICAs and the SSSs were extracted from the resting state fMRI data. The maximum cross‐correlation coefficients and their corresponding delay times were calculated. The gender and age differences of delay times were assessed statistically. Statistical Tests T‐tests were conducted to measure the gender differences. The Kruskal–Wallis test was used to detect age differences. Results Consistent and robust results were found from 80% of the 400 HCP scans included. Negative correlations (–0.67) between the ICA and the SSS signals were found with the ICA signal leading the SSS signal by ∼5 sec. Within subject variation was 2.23 sec at the 5% significance level. The delay times were not significantly different between genders (P = 0.9846, P = 0.2288 for the left and right ICA, respectively). Significantly shorter delay times (4.3 sec) were found in the children than in the adults (P < 0.01). Data Conclusion We have shown that meaningful perfusion information (ie, CCT) can be derived from the sLFO fMRI signals of the large blood vessels. Level of Evidence: 1 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2019;50:1504–1513.

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Dopplersonographic measurement of global cerebral circulation time using echo contrast-enhanced ultrasound in normal individuals and patients with arteriovenous malformations

Cited by 35 publications

References 18 publications

Ultrasonographic Assessment of Global Cerebral Blood Volume in Healthy Adults

Ultrasonographic Assessment of Global Cerebral Blood Volume in Healthy Adults

Tracking cerebral blood flow in BOLD fMRI using recursively generated regressors

Cerebral circulation time derived from fMRI signals in large blood vessels

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