Doppler ultrasonography imaging of hemodynamic alteration of retrobulbar circulation in type 1 diabetic children and adolescents without retinopathy

Ovalı, Gülgün Yılmaz; Ersoy, Betül; Tunçyürek, Özüm; Ürk, Vildan; Özkol, Mine; Özhan, Bayram; Başer, Esin; Pabuşçu, Yüksel

doi:10.1016/j.diabres.2007.09.001

Cited by 16 publications

(11 citation statements)

References 27 publications

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“…2000) or unchanged velocities compared with healthy controls (Goebel et al. 1995; Yilmaz Ovali et al. 2008).…”

Section: Discussionmentioning

confidence: 99%

“…Some investigators included type 1 diabetes patients with no diabetic retinopathy (Kawagishi et al. 1995; Yilmaz Ovali et al. 2008), whereas other included both type 1 and type 2 diabetes patients with various stages of retinopathy from no to proliferative retinopathy (Mendívil et al.…”

Section: Discussionmentioning

confidence: 99%

“…2000), whereas other groups reported that blood flow velocity is unchanged (Goebel et al. 1995; Yilmaz Ovali et al. 2008) or even increased compared with healthy controls (Dimitrova et al.…”

Section: Introductionmentioning

confidence: 92%

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Calculation of central retinal artery diameters from non‐invasive ocular haemodynamic measurements in type 1 diabetes patients

Pemp

Popa-Cherecheanu

Garhöfer

et al. 2013

Acta Ophthalmologica

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ABSTRACT.Purpose: The aim of the study was to compare the diameter of the central retinal artery (CRA) between patients with diabetes mellitus and healthy subjects in vivo. CRA diameters were calculated from retinal haemodynamic parameters measured with noninvasive measurement techniques.Methods: Sixteen patients with type 1 diabetes with no or mild diabetic retinopathy and 16 age-matched healthy controls were included in this study. Total retinal blood flow was assessed by combining bidirectional laser Doppler velocimetry in all veins entering the optic disc with measurements of retinal vessel diameters using a Dynamic Vessel Analyser. Blood flow velocity in the CRA was measured with colour Doppler imaging (CDI). The diameter of the CRA in the optic nerve was then calculated for each subject using the individual ocular haemodynamic data.Results: Calculated CRA diameters were significantly larger in patients with diabetes (180 ± 13 lm) compared with healthy controls (166 ± 10 lm, p = 0.001). No significant differences were found in retinal blood flow, retinal artery or vein diameters or mean flow velocity of the CRA. Conclusion:The data of the present study show increased calculated CRA diameter in patients with type 1 diabetes with no or mild retinopathy. Blood flow velocity measurements in retrobulbar vessels using CDI need to be interpreted with caution in terms of retinal blood flow, because no information about vessel diameters is obtained by this technique.

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“…2000) or unchanged velocities compared with healthy controls (Goebel et al. 1995; Yilmaz Ovali et al. 2008).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Calculation of central retinal artery diameters from non‐invasive ocular haemodynamic measurements in type 1 diabetes patients

Pemp

Popa-Cherecheanu

Garhöfer

et al. 2013

Acta Ophthalmologica

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“…There are promising results of altered ocular blood flow in common ocular diseases like diabetic retinopathy, age related macular disease and several forms of glaucoma [24, 27–31] and growing evidence showing that ocular blood flow alterations are associated with the development and progression of ophthalmologic diseases confirm the notion that abnormalities in vessel function exist before the development of structural changes occur. Considering this exciting point of view it seems promising to focus research of preclinical changes of ocular blood flow and prediction of progression of respective diseases.…”

Section: Discussionmentioning

confidence: 99%

Colour Doppler analysis of ophthalmic vessels in the diagnosis of carotic artery and retinal vein occlusion, diabetic retinopathy and glaucoma: systematic review of test accuracy studies

et al. 2016

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BackgroundColour Doppler analysis of ophthalmic vessels has been proposed as a promising tool in the diagnosis of various eye diseases, but the available diagnostic evidence has not yet been assessed systematically. We performed a comprehensive systematic review of the literature on the diagnostic properties of Colour Doppler imaging (CDI) assessing ophthalmic vessels and provide an inventory of the available evidence.MethodsEligible papers were searched electronically in (Pre) Medline, Embase and Scopus, and via cross-checking of reference lists. The minimum requirement to be included was the availability of original data and the possibility to construct a two-by-two table. Study selection, critical appraisal using the QUADAS II instrument and extraction of salient study characteristics was made in duplicate. Sensitivity and specificity was computed for each study.ResultsWe included 11 studies (15 two-by-two tables) of moderate methodological quality enrolling 820 participants (range 30 to 118). In 44.4% participants were female (range 37–59% in specific subgroups). CDI was assessed for internal carotid stenosis, diabetic retinopathy, glaucoma, and branch or central retinal vein occlusion diagnosis. There was insufficient data to pool the results for specific illnesses. For the assessments of ophthalmic arteries, mean sensitivity was 0.69 (range 0.27–0.96) with a corresponding mean specificity of 0.83 (range 0.70–0.96). Mean sensitivity of the central retinal artery assessments was 0.58 (range 0.31–0.84) and the corresponding mean specificity was 0.82 (range 0.63–0.94).ConclusionsRobust assessments of the diagnostic value of colour Doppler analysis remain uncommon, limiting the possibilities to extrapolate its true potential for clinical practice.PROSPERO 2014:CRD42014014027.

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“…Ocular vascular changes and, consequently, hemodynamic changes play the pivotal roles in the pathogenesis of diabetic retinopathy 26 – 29 . However, the effects of diabetes mellitus on the retinal circulation have been studied with conflicting evidence as to whether blood supplying the retina is increased or decreased 11 – 14 …”

Section: Discussionmentioning

confidence: 99%

Color Doppler Imaging Analysis of Retrobulbar Blood Flow Velocities in Diabetic Patients Without or With Retinopathy

Meng

Liu

Zhang

et al. 2014

J of Ultrasound Medicine

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Doppler ultrasonography imaging of hemodynamic alteration of retrobulbar circulation in type 1 diabetic children and adolescents without retinopathy

Cited by 16 publications

References 27 publications

Calculation of central retinal artery diameters from non‐invasive ocular haemodynamic measurements in type 1 diabetes patients

Calculation of central retinal artery diameters from non‐invasive ocular haemodynamic measurements in type 1 diabetes patients

Colour Doppler analysis of ophthalmic vessels in the diagnosis of carotic artery and retinal vein occlusion, diabetic retinopathy and glaucoma: systematic review of test accuracy studies

Color Doppler Imaging Analysis of Retrobulbar Blood Flow Velocities in Diabetic Patients Without or With Retinopathy

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