Doppler Ultrasonographic Evaluation of Gastrointestinal Hemodynamics in Food Hypersensitivities: A Canine Model

Kircher, Patrick R.; Spaulding, Kathy A.; Vaden, Shelly L.; Lang, Johann; Doherr, Marcus G.; Gaschen, Lorrie

doi:10.1111/j.1939-1676.2004.tb02594.x

Cited by 14 publications

(2 citation statements)

References 34 publications

(39 reference statements)

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“…A recent study has reported a novel non-invasive procedure involving Doppler ultrasound analysis of the coeliac and cranial mesenteric arteries in dogs with food allergy challenged orally with the antigen to which they were most reactive. The observed lowered resistance to diastolic flow is interpreted to reflect vasodilation occurring as part of the local intestinal inflammatory response, and the authors propose that this test may be of diagnostic value in patients with food allergy (Kircher et al 2004).…”

Section: Spontaneously-arising Canine Dietary Hypersensitivitymentioning

confidence: 99%

The canine model of dietary hypersensitivity

Day

2005

Proc. Nutr. Soc.

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IgE-mediated dietary hypersensitivity affects approximately 1 % of the canine population. There are no breed associations and £50 % of the patients are aged < 1 year at presentation. The most common causative allergens are beef, chicken, milk, eggs, maize, wheat and soyabean. Affected dogs generally display cutaneous disease and 10-15 % of the patients may have concurrent alimentary involvement. Diagnosis is currently based on dietary restriction followed by provocation. Procedures for the detection of serum allergen-specific IgE and IgG antibodies are widely available, but these tests correlate poorly with clinical presentation and dietary testing. Recent studies have demonstrated the allergen specificity of IgE antibodies by immunoblotting and have described blood lymphocyte proliferative responses to food allergens. In addition to investigations of spontaneously-arising dietary hypersensitivity, it has also proved possible to study this disorder experimentally. Small colonies of dogs sensitive to particular dietary proteins have been used to study clinical and serological responses to allergen challenge. Hypersensitivity has been experimentally induced in dogs of an atopic phenotype by repeated subcutaneous injection of alum-adjuvanted dietary allergen during neonatal life. These models have been used to trial a range of modified protein or hydrolysate diets. The dog provides a unique large-animal model for investigation of the immunopathogenesis of human dietary hypersensitivity. The dog is closely related genetically to man and shares environmental disease triggers with man. Spontaneously arising canine dietary hypersensitivity is a good clinical mimic of the human disease, and ability to therapeutically manipulate this adverse response in the dog might lead to benefits for human patients. Dog: Food allergy

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Section: Spontaneously-arising Canine Dietary Hypersensitivitymentioning

confidence: 99%

The canine model of dietary hypersensitivity

Day

2005

Proc. Nutr. Soc.

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“…The velocity of blood flow in the superior mesenteric artery was markedly higher in CD patients compared to controls. By contrast, the resistance index of the superior mesenteric artery was lower in active CD than controls[ 42 , 43 ]. The cumulative clinical evidence suggests that the function of vasculature is altered in CD.…”

Section: Blood Vesselsmentioning

confidence: 99%

Role of mesenteric component in Crohn’s disease: A friend or foe?

Yin¹,

Zhu²,

Li³

et al. 2021

WJGS

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Crohn’s disease (CD) is a complex and relapsing gastrointestinal disease with mesenteric alterations. The mesenteric neural, vascular, and endocrine systems actively take part in the gut dysbiosis-adaptive immunity-mesentery-body axis, and this axis has been proven to be bidirectional. The abnormalities of morphology and function of the mesenteric component are associated with intestinal inflammation and disease progress of CD via responses to afferent signals, neuropeptides, lymphatic drainage, adipokines, and functional cytokines. The hypertrophy of mesenteric adipose tissue plays important roles in the pathogenesis of CD by secreting large amounts of adipokines and representing a rich source of proinflammatory or profibrotic cytokines. The vascular alteration, including angiogenesis and lymphangiogenesis, is concomitant in the disease course of CD. Of note, the enlarged and obstructed lymphatic vessels, which have been described in CD patients, are likely related to the early onset submucosa edema and being a cause of CD. The function of mesenteric lymphatics is influenced by endocrine of mesenteric nerves and adipocytes. Meanwhile, the structure of the mesenteric lymphatic vessels in hypertrophic mesenteric adipose tissue is mispatterned and ruptured, which can lead to lymph leakage. Leaky lymph factors can in turn stimulate adipose tissue to proliferate and effectively elicit an immune response. The identification of the role of mesentery and the crosstalk between mesenteric tissues in intestinal inflammation may shed light on understanding the underlying mechanism of CD and help explore new therapeutic targets.

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