Abstract:Acute hyperglycemia induced in healthy pregnant women does not affect blood flow velocimetric characteristics in the umbilical or uterine arteries at any stage of oral glucose tolerance testing.
“…Earlier studies concerning the possible effects of maternal glucose intake on placental blood flow measured umbilical artery blood flow velocity indices, i.e. indirect measures of flow impedance . A strength of the present study is the use of volume blood flow which by definition measures organ perfusion.…”
Section: Discussionmentioning
confidence: 97%
“…The proportion of UV flow that perfuses the liver is related to maternal weight gain during pregnancy and to body composition and diet before pregnancy . We are unaware of any studies on the short‐term effects of diets that vary in carbohydrate content on human fetal volume blood flow (ml/min); however, no immediate effect of maternal glucose load on umbilical artery Doppler resistance indices has been shown .…”
“…Earlier studies concerning the possible effects of maternal glucose intake on placental blood flow measured umbilical artery blood flow velocity indices, i.e. indirect measures of flow impedance . A strength of the present study is the use of volume blood flow which by definition measures organ perfusion.…”
Section: Discussionmentioning
confidence: 97%
“…The proportion of UV flow that perfuses the liver is related to maternal weight gain during pregnancy and to body composition and diet before pregnancy . We are unaware of any studies on the short‐term effects of diets that vary in carbohydrate content on human fetal volume blood flow (ml/min); however, no immediate effect of maternal glucose load on umbilical artery Doppler resistance indices has been shown .…”
“… did not observe any changes in UA PI except an increase in women with higher plasma glucose levels after GCT. Three other small studies including between 15 and 30 pregnancies from gestational weeks 24 to term used 50‐, 75‐ or 100‐g glucose intake. The examinations were performed before and 1–3 h after maternal glucose loading.…”
Section: Discussionmentioning
confidence: 99%
“…Using a 50-g glucose challenge test (GCT) on 21 pregnancies at 24-28 weeks of gestation Pardo et al (6) did not observe any changes in UA PI except an increase in women with higher plasma glucose levels after GCT. Three other small studies (5,7,9) including between 15 and 30 pregnancies from gestational weeks 24 to term used 50-, 75-or 100-g glucose intake.…”
Introduction. Our aim was to study umbilical and fetal cerebral arterial blood flow velocity waveforms related to fetal biometric measures and maternal body mass index, glucose levels and parity following maternal oral glucose loading. Material and methods. The study had an experimental design in a cross-sectional observational study including 105 low-risk pregnancies (30-32 weeks of gestation). Ultrasound Doppler measurements of umbilical and middle cerebral arterial (UA and MCA) velocity waveforms were performed before and at 2 h after completed 75-g oral glucose tolerance tests (OGTT). We assessed changes in UA and MCA pulsatility indices (PI). Results. MCA PI was significantly reduced following OGTT (p < 0.001); these changes were not related to changes in fetal heart rate (r = À0.11, p = 0.278). UA PI was also significantly reduced following OGTT (p = 0.033); these changes were related to fetal heart rate (r = À0.47, p < 0.001). This reduction was not significant (p = 0.230) when the PI values were adjusted for fetal heart rate. The ratio MCA PI to UA PI was reduced (p = 0.001). The effect of OGTT on MCA PI was not related to fetal abdominal circumference whereas the effect on the adjusted UA PI values was correlated to abdominal circumference (r = À0.20, p = 0.045) but not to abdominal circumference Z-score (r = À0.16, p = 0.115). The influence of OGTT on the Doppler parameters as well as heart rates was not related to prepregnant body mass index, glucose levels before or after OGTT, parity, fetal sex or gestational age. Conclusions. Maternal glucose loading seems to decrease fetal cerebral blood flow impedance independent of fetal size.
“…Further, it could be a result of the low‐risk cohort studied 25 . Healthy pregnant women adapt to acute changes in blood glucose level without major changes in the uterine artery blood flow velocity 26 . The UADV was not affected by the number of days fasting.…”
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