Doppler perfusion index (DPI) and homa are highly predictive of fatty liver in patients with NAFLD

Dugoni, Manfredo; Miglioli, L.; Borelli, Lucia; Anderlini, R.; Bedogni, Giorgio; Mariano, M.; Battistini, N.; Bellentani, Stefano

doi:10.1016/j.dld.2007.12.097

Cited by 5 publications

(4 citation statements)

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“…For example, elevated DPI has been shown to be present in patients with metastatic colorectal cancer [112]. In small trials, altered DPI has been found in patients with NAFLD [113][114][115]. However, the full results were not disclosed.…”

Section: Imagingmentioning

confidence: 98%

Nonalcoholic Fatty Liver Disease: A Review and Update

2010

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The spectrum of nonalcoholic fatty liver disease (NAFLD) ranges from asymptomatic steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. Hepatic steatosis occurs when free fatty acids, released in the setting of insulin resistance and the metabolic syndrome, are taken up by the liver. Additional biochemical insults, including oxidative stress, upregulation of inflammatory mediators, and dysregulated apoptosis, can result in inflammation (producing NASH) and fibrosis. Noninvasive methods (e.g., abdominal ultrasonography) are safe ways to support a diagnosis of hepatic steatosis, but advanced liver histopathologic findings including NASH and fibrosis cannot be identified without pursuing liver biopsy. Recent advances in serologic and imaging methods aim to determine severity of inflammation and fibrosis noninvasively. Currently, therapeutic options for NAFLD are limited to medications that reduce risk factors, but the future holds promise for therapies that might slow the progression of this increasingly prevalent disorder.

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Section: Imagingmentioning

confidence: 98%

Nonalcoholic Fatty Liver Disease: A Review and Update

2010

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“…In addition, they indicated that the grade of fatty liver was inversely associated with DPI (16). In the study by Dugoni et al, DPI was significantly higher in adults with NAFLD and was highly predictive of fatty liver in these patients (27). The differences between our findings with the studies by Kakkos et al ( 16) and Dugoni et al (27) can be explained by the fact that subjects in these studies were obese and overweight adult patients whereas the patients in our study were adolescents with NAFLD.…”

Section: Discussionmentioning

confidence: 95%

“…Doppler perfusion index (DPI) that has been used in the detection of overt liver metastatic disease examines the relationship between HABF volume and total liver blood flow (26). Studies revealed that DPI has changed in patients with fatty liver (16,27). As mentioned above, several methods with different weaknesses and strengths have been used to diagnose fatty liver in patients; however, there is limited evidence regarding the application of DPI as compared to other diagnostic modalities, especially in adolescence.…”

Section: Key Pointmentioning

confidence: 99%

Doppler perfusion index in adolescents with non-alcoholic fatty liver disease

et al. 2020

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Introduction: Non-alcoholic fatty liver disease (NAFLD) as a multi-factorial disorder is the most common cause of abnormal liver function tests in adolescents. Objectives: The present study aimed to assess Doppler perfusion index (DPI) in adolescents with NAFLD as compared with healthy subjects. Patients and Methods: Thirty-seven adolescents with NAFLD and 25 healthy individuals were enrolled in the study. Hemodynamic indices were measured using a color Doppler ultrasound machine. Severity of fatty liver disease and steatosis grade were assessed using FibroScan. The measured indices were peak systolic velocity (PSV), resistive index (RI), end-diastolic velocity (EDV), time-averaged mean velocity (TAMV), time-averaged peak velocity (TAPV), portal venous blood flow (PVBF) volume, hepatic arterial blood flow (HABF) volume, and DPI. Results: The mean of DPI in the case and control groups was 0.31±0.11 and 0.31±0.09, respectively (P=0.972). HABF volume was significantly lower in the case group as compared with the control group (103.8 versus 153.3 respectively, P=0.015). PSV, TAMV, mean velocity, and PVBF volume were significantly lower in the case group as compared with the control group (P<0.05). Patients with a higher steatosis grade indicated a significantly lower mean of PSV and TAMV portal than controls (P<0.05). Conclusion: DPI was similar in adolescents with NAFLD and healthy subjects and was not associated with severity of fatty liver disease and steatosis grade. In addition, the percentage of steatosis would be increased with increased liver span.

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“…DPI allows for the detection of overt liver metastatic disease and helps to differentiate between benign and malignant focal hepatic lesions [Kyriakopoulou et al ,2008]. DPI was also found predictive of the liver steatosis in patients with NAFLD in the study conducted on a small group of patients, therefore it requires further evaluation [Dugoni et al 2007]. Conventional Doppler ultrasound examination of hepatic vasculature is, unfortunately not a good tool to evaluate mild and moderate fibrosis.…”

Section: Doppler Ultrasoundmentioning

confidence: 99%

Non-Invasive Assessment of the Liver – Serum Markers and Imaging Techniques

Mania¹,

Kemnitz²,

Mazur‐Melewska³

et al. 2011

Liver Biopsy

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Management and prognosis of the liver diseases highly depends on the advancement of the liver lesions. It is particularly important to distinguish patients at greatest risk of developing liver cirrhosis, liver failure and hepatocellular carcinoma. Liver biopsy remains the gold standard for evaluating the liver tissue. It allows not only for establishing the grade of inflammatory activity and the stage of fibrosis, but also for more accurate differential diagnosis and detection of coexisting liver diseases. Needle biopsy removes, however, only about 1/50,000 of the liver tissue and carries the risk of sampling error. Furthermore, the specimen should be sufficient in length (20-25 mm), width, fragmentation and number of complete portal tracts (at least 11) [Cholongitas et al., 2006]. Moreover, liver assessment is affected by significant interpretative error and interobserver variability of histological interpretation. Besides, many patients are reluctant to experience repeated biopsies, which limits the ability to monitor disease progression and the effects of treatments. Search for new non-invasive approaches have been initiated as a result of the limitations of the liver biopsy. Non-invasive tests for the assessment of the severity of chronic liver diseases seem to be an attractive option designed to replace liver biopsy in the near future. Ideal non-invasive marker of particular liver lesion should be reliable, liver specific, inexpensive and easy to perform. In addition, it should allow not only to diagnose particular liver problem but also to monitor its progression. Recently extensive research is performed to evaluate non-invasive techniques for the detection of liver fibrosis, necroinflammatory activity and steatosis in various liver diseases. This chapter revises currently used noninvasive techniques of liver assessment. 2. Serum biochemical markers 2.1 Serum markers of fibrosis in hepatitis The progression of liver fibrosis is a complex wound-healing process, that involves various types of cells and their mediators that eventually leads to the deposition and accumulation of various extracellular matrix (ECM) components. www.intechopen.com Liver Biopsy 266 Serum biochemical tests including direct and indirect markers of fibrosis have been most widely investigated. Certain markers, especially cytokines, growth factors, metaloproteinases and their inhibitors may reflect balance or imbalance between fibrogenesis and fibrinolysis, revealing information about the progression of the disease. 2.2 Direct markers Direct markers include profibrotic cytokines as transforming growth factor beta-1 (TGF beta-1), ECM components-glycoproteins as hyaluronan (HA), laminin, metaloproteinases their tissue inhibitors and others. Some of them demonstrated associations with liver fibrosis. Fibryl-forming collagens accumulate in the process of liver fibrosis being important components of extracellular matrix. The most extensively studied collagen is PIIINP, an aminotreminal peptide of procollagen III, that is cleaved from procolag...

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Doppler perfusion index (DPI) and homa are highly predictive of fatty liver in patients with NAFLD

Cited by 5 publications

References 0 publications

Nonalcoholic Fatty Liver Disease: A Review and Update

Nonalcoholic Fatty Liver Disease: A Review and Update

Doppler perfusion index in adolescents with non-alcoholic fatty liver disease

Non-Invasive Assessment of the Liver – Serum Markers and Imaging Techniques

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