Doppel-Philadelphia-Chromosom und Isochromosom 17 in der terminalen Phase der chronischen myeloischen Leukämie

Ph¹-Disomy and Prognosis in Chronic Myelogenous Leukaemia

“…Sufficient chronological data are given in 8 patients described in the literature (7,8,10,16,17,18). In one patient (Case No.…”

Marker Chromosome in Myeloproliferative Syndrome

“…In this case the double or triple Philadelphia chromosome is the most typical in addition to the numerical aberrations. The development of isochromosomes is also comparatively frequent, and concerns generally one of the long arms of chromosome 17 or 18 [1,5,8,10]. Using the banding technique Lobb et al [6] demon strated recently in three cases the presence of the isomarker mentioned above, and assumed that this phenomenon is generally more frequent in tumorous diseases.…”

Two Ph1 Chromosomes in Blastic Crisis of a Granulocytic Leukaemia

“…Recently some cases of CGL in acute crisis (3,4,5,6,7,9,13,14), two cases in chronic phase (2,13) and one case of AML (9), have been described in which two Phi chromosomes were present. Two of these cases showed double Phi chromosomes in diploid cells also, another two cases contained Phi disomy in hypodiploid cells as well, all other cases had two Phi chromosomes in hyper diploid cells only.…”