Doping bioactive elements into a collagen scaffold based on synchronous self-assembly/mineralization for bone tissue engineering

Liu, Huanhuan; Lin, Mingli; Li, Xue; Zhang, Ye; Luo, Yang; Pang, Yanyun; Chen, Haitao; Zhu, Dongwang; Zhong, Xichun; Ma, Shiqing; Zhao, Yanhong; Yang, Qiang; Zhang, Xu

doi:10.1016/j.bioactmat.2020.06.005

Cited by 56 publications

(18 citation statements)

References 56 publications

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“…152RM is essentially a polypeptide that needs to be released stably under the control of appropriate scaffolds. Under acidic conditions in bone defects, collagen matrix formation is thought to precede mineralization [ 13 ]. Demineralized bone matrix (DBM) is a porous bone bioactive scaffold that is composed of collagen I and has cell adhesion and osteogenesis induction capacity [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering

Tang

Luo

Chen

et al. 2021

Bioactive Materials

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Section: Introductionmentioning

confidence: 99%

Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering

Tang

Luo

Chen

et al. 2021

Bioactive Materials

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“…Meanwhile, incorporation of strontium may contribute to osseointegration via its proven capability has been proven to of triggering new bone formation through enhanced osteoblastic activity [ 64 , 65 ]. In the context of infectious bone implantation, the synergy between antibacterial and osteogenic properties ought to be the two unreplaceable determinants leading to rapid and strong osseointegration [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

“…In this aspect, the biomimetic mineralized coatings exhibit a variety of rough surface microstructures, which contains many promising biological values [ 35 ]. Besides, it is a feasible way to integrate metal ions such as zinc ion into the mineral layer to obtain some potential biological functions [ 36 , 37 ]. Thus, we hypothesized that integration of these alternative approaches which intrinsically possess antibacterial properties onto implant surfaces, could serve as an efficient anti-infection strategy and overcome the shortcomings associated with antibiotic-eluting implants.…”

Section: Introductionmentioning

confidence: 99%

A trilogy antimicrobial strategy for multiple infections of orthopedic implants throughout their life cycle

Yikai

Teng

Zhang

et al. 2021

Bioactive Materials

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Bacteria-associated infection represents one of the major threats for orthopedic implants failure during their life cycles. However, ordinary antimicrobial treatments usually failed to combat multiple waves of infections during arthroplasty and prosthesis revisions etc. As these incidents could easily introduce new microbial pathogens in/onto the implants. Herein, we demonstrate that an antimicrobial trilogy strategy incorporating a sophisticated multilayered coating system leveraging multiple ion exchange mechanisms and fine nanotopography tuning, could effectively eradicate bacterial infection at various stages of implantation. Early stage bacteriostatic effect was realized via nano-topological structure of top mineral coating. Antibacterial effect at intermediate stage was mediated by sustained release of zinc ions from doped CaP coating. Strong antibacterial potency was validated at 4 weeks post implantation via an implanted model in vivo . Finally, the underlying zinc titanate fiber network enabled a long-term contact and release effect of residual zinc, which maintained a strong antibacterial ability against both Staphylococcus aureus and Escherichia coli even after the removal of top layer coating. Moreover, sustained release of Sr 2+ and Zn 2+ during CaP coating degradation substantially promoted implant osseointegration even under an infectious environment by showing more peri-implant new bone formation and substantially improved bone-implant bonding strength.

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“…The results mentioned before prove that the combined application of bioskiving and adequate sonication treatment is a feasible approach for preparing the porous collagen membrane. Recently, synchronous self-assembly/mineralization (SSM) is an emerging novel approach to fabricate mineralized porous collagen membranes ( Lin et al, 2019 ; Liu et al, 2020 ). In brief, collagen molecules and amorphous mineral nanoparticles stabilized by the polyampholytes were mixed in the acidic solution.…”

Section: Discussionmentioning

confidence: 99%

A Rapid and Convenient Approach to Construct Porous Collagen Membranes via Bioskiving and Sonication-Feasible for Mineralization to Induce Bone Regeneration

Zhong²,

Yu³

et al. 2021

Front. Bioeng. Biotechnol.

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Porous mineralized collagen membranes efficiently promote bone regeneration. To generate them, we need to fabricate collagen membranes that are porous. However, the current fabrication method is primarily based on a bottom-up strategy, with certain limitations, such as a long manufacturing process, collagen denaturation, and failure to control fibril orientation. Using a top-down approach, we explore a novel method for constructing porous collagen membranes via the combined application of bioskiving and sonication. Numerous collagen membranes with well-aligned fibril structures were rapidly fabricated by bioskiving and then sonicated at 30, 60, 90, and 120 W for 20 min. This treatment allowed us to study the effect of power intensity on the physicochemical traits of collagen membranes. Subsequently, the prepared collagen membranes were immersed in amorphous calcium phosphate to evaluate the feasibility of mineralization. Additionally, the bioactivities of the membranes were assessed using preosteoblast cells. Tuning the power intensity was shown to modulate fibril orientation, and the porous membrane without denatured collagen could be obtained by a 20-min sonication treatment at 90 W. The prepared collagen membrane could also be further mineralized to enhance osteogenesis. Overall, this study offers a rapid and convenient approach for fabricating porous collagen membranes via bioskiving and sonication.

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Doping bioactive elements into a collagen scaffold based on synchronous self-assembly/mineralization for bone tissue engineering

Cited by 56 publications

References 56 publications

Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering

Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering

A trilogy antimicrobial strategy for multiple infections of orthopedic implants throughout their life cycle

A Rapid and Convenient Approach to Construct Porous Collagen Membranes via Bioskiving and Sonication-Feasible for Mineralization to Induce Bone Regeneration

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