Doped Ferrite Nanoparticles Exhibiting Self-Regulating Temperature as Magnetic Fluid Hyperthermia Antitumoral Agents, with Diagnostic Capability in Magnetic Resonance Imaging and Magnetic Particle Imaging

Abstract

This paper reports a comprehensive investigation of a magnetic nanoparticle (MNP), named M55, which belongs to a class of innovative doped ferrite nanomaterials, characterized by a self-limiting temperature. M55 is obtained from M48, an MNP previously described by our group, by implementing an additional purification step in the synthesis. M55, after citrate and glucose coating, is named G-M55. The present study aimed to demonstrate the properties of G-M55 as a diagnostic contrast agent for MRI and magnetic particle imaging (MPI), and as an antitumoral agent in magnetic fluid hyperthermia (MFH). Similar specific absorption rate values were obtained by standard MFH and by an MPI apparatus. This result is of interest in relation to the application of localized MFH by MPI apparatus. We demonstrated the biocompatibility of G-M55 in a triple-negative human breast cancer line (MDA-MB-231), and its efficacy as an MFH agent in the same cell line. We also demonstrated the efficacy of MFH treatment with G-M55 in an experimental model of breast cancer. Overall, our results pave the way for the clinical application of G-M55 as an MFH agent in breast cancer therapy, allowing not only efficient treatment by both standard MFH apparatus and MPI but also temperature monitoring.

Optical magnetic field sensors based on nanodielectrics: From biomedicine to IoT‐based energy internet

“…Besides, some advanced amorphous alloy materials such as Metglas and FeSiB [19] are extensively applied and suitable for fabricating sensitive components to satisfy various demands such as energy harvesting [20], as well as the detection of special frequency magnetic fields [21]. Although the continuous progress of materials promotes the development of the sensors, the application of magnetostrictive materials in some special fields still has limitations, such as targeted drug delivery [22, 23], diagnosis [24, 25], and therapeutic [26]. Due to the lack of comprehensive and systematic biosafety research on in vitro and in vivo biocompatibility of magnetostrictive materials [27], coupled with lack of fluidity, it is difficult to be applied in vivo drug delivery, treatment, and other fields.…”

Progress in magnetic particle imaging signal and iron quantification methods in vivo – application to long circulating SPIONs

“…4,5 However, as these tracers continue to improve through metal doping and polymer coatings, their circulation will extend and produce more complex MPI images. 12,13 Further, in the case of intravenously (IV) administered SPION, the tracer is distributed across the vasculature and different organs, increasing the signal's bleed and making it difficult to accurately determine the size of a ROI and therefore quantify the amount of iron. To support the growth of MPI research, it is important to establish a precise, reproducible and universal analysis method that is user-independent for accurate iron quantication based on MPI signals throughout the entire body and individual organs.…”