Dopaminergic reward system: a short integrative review

Arias-Carrión, Óscar; Stamelou, María; Murillo-Rodrı́guez, Eric; Menéndez-González, Manuel; Pöppel, Ernst

doi:10.1186/1755-7682-3-24

Cited by 309 publications

(185 citation statements)

References 74 publications

(92 reference statements)

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“…By providing information about the individual value and significance of environmental stimuli, these dopaminergic projections profoundly influence behavior and modulate higher brain functions (Arias-Carrion et al 2010;Bromberg-Martin et al 2010). Between species, pronounced differences in magnitude and complexity of cortical dopaminergic innervation have to be taken into account.…”

Section: Introductionmentioning

confidence: 99%

Topography and collateralization of dopaminergic projections to primary motor cortex in rats

2015

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Dopaminergic signaling within the primary motor cortex (M1) is necessary for successful motor skill learning. Dopaminergic neurons projecting to M1 are located in the ventral tegmental area (VTA, nucleus A10) of the midbrain. It is unknown which behavioral correlates are encoded by these neurons. The objective here is to investigate whether VTA-M1 fibers are collaterals of projections to prefrontal cortex (PFC) or nucleus accumbens (NAc) or if they form a distinct pathway. In rats, multiple-site retrograde fluorescent tracers were injected into M1, PFC and the core region of the NAc and VTA sections investigated for concomitant labeling of different tracers. Dopaminergic neurons projecting to M1, PFC and NAc were found in nucleus A10 and to a lesser degree in the medial nucleus A9. Neurons show high target specificity, minimal collateral branching to other than their target area and hardly cross the midline. Whereas PFC-and NAc-projecting neurons are indistinguishably intermingled within the ventral portion of dopaminergic nuclei in middle and caudal midbrain, M1-projecting neurons are only located within the dorsal part of the rostral midbrain. Within M1, the forelimb representation receives sevenfold more dopaminergic projections than the hindlimb representation. This strong rostro-caudal gradient as well as the topographical preference to dorsal structures suggest that projections to M1 emerged late in the development of the dopaminergic systems in and form a functionally distinct system.

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Section: Introductionmentioning

confidence: 99%

Topography and collateralization of dopaminergic projections to primary motor cortex in rats

2015

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“…Surprisingly, the D1R partial agonist ((+/−)-1-phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7, 8-diol hydrochloride) (SKF-38393) also decreased alcohol intake in both rats (Cohen et al 1999;Dyr et al 1993;Silvestre et al 1996) and mice (Ng and George 1994). We are focusing on D1 receptors expressed in medium spiny neurons, because they are expressed at high levels in the ventral striatum (Caille et al 1996;Matamales et al 2009;Muly et al 2010;Podda et al 2010) and are thought to be major regulators of dopaminergic neurons originating from the ventral tegmental area (VTA) that provide innervation to the NAc (Altier and Stewart 1999;Arias-Carrion et al 2010;Cooper 2002;Gonzales et al 2004;Herz 1997;McBride et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Involvement of nucleus accumbens dopamine D1 receptors in ethanol drinking, ethanol-induced conditioned place preference, and ethanol-induced psychomotor sensitization in mice

Bahí

Dreyer

2012

Psychopharmacology

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Rationale Dopamine D1 receptor (D1R) signaling has been associated to ethanol consumption and reward in laboratory animals. Objectives Here, we hypothesize that this receptor, which is located within the nucleus accumbens (NAc) neurons, modulates alcohol reward mechanisms. Methods To test this hypothesis, we measured alcohol consumption and ethanol-induced psychomotor sensitization and conditioned place preference (CPP) in mice that received bilateral microinjections of small interference RNA (siRNA)-expressing lentiviral vectors (LV-siD1R) producing D1R knock-down. The other group received control (LV-Mock) viral vectors into the NAc. Results There were no differences in the total fluid consumed and also no differences in the amount of ethanol consumed between groups prior to surgery. However, after surgery, the LV-siD1R group consumed less ethanol than the control group. This difference was not associated to taste neophobia. In addition, results have shown that downregulation of endogenous D1R using viral-mediated siRNA in the NAc significantly decreased ethanol-induced behavioral sensitization as well as acquisition, but not expression, of ethanol-induced place preference.Conclusions We conclude that decreased D1R expression into the NAc led to reduced ethanol rewarding properties, thereby leading to lower voluntary ethanol consumption. Together, these findings demonstrate that the D1 receptor pathway within the NAc controls ethanol reward and intake.

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“…At present, the mechanism of methamphetamine addiction is not clear, but previous studies have shown that methamphetamine addiction is associated with the dopamine reward system in the ventral tegmental area of the brain [21]. Methamphetamine is an indirect agonist of dopamine that promotes the release of monoamine neurotransmitter [22][23].…”

Section: Mechanisms Of Psychiatric Diseasementioning

confidence: 92%

Nanomedicine: A New Approach for Treatment Neuropsychiatric Diseases

Wang¹,

Xue²

2017

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Abstract:Nervous system diseases, such as Alzheimer's disease, stroke, and Parkinson's disease, are spreading around the world. These diseases involve complicatedly pathological processes, and so far, there are no effective medicines for therapy. Another type of psychiatric disorder is induced by drugs. The synthetic drugs, represented by methamphetamine, are becoming widely abuse. At present, the cure of methamphetamine dependence is mainly symptomatic treatment, but the recurrence rate is very high. As the common brain impairments in neuropsychiatric disease, it is necessary to summary novel strategies effectively restored brain function. In recent years, carbon nanotubes have attracted the attention due to their unique properties in the field of translational medicine. Recently, new advances reported that carbon nanotubes as a nanomedicine to treat various neuropsychiatric disorders. The purpose of this review is to introduce the therapeutic approaches and mechanisms of carbon nanotubes on neuropsychiatric disorders.

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Dopaminergic reward system: a short integrative review

Cited by 309 publications

References 74 publications

Topography and collateralization of dopaminergic projections to primary motor cortex in rats

Topography and collateralization of dopaminergic projections to primary motor cortex in rats

Involvement of nucleus accumbens dopamine D1 receptors in ethanol drinking, ethanol-induced conditioned place preference, and ethanol-induced psychomotor sensitization in mice

Nanomedicine: A New Approach for Treatment Neuropsychiatric Diseases

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