Dopaminergic receptor sites in human brain

Baron, Jean‐Claude; Comar, D.; Zarifian, E.; Agid, Yves; Crouzel, C.; Lôo, Henri; Deniker, P; Kellershohn, C.

doi:10.1212/wnl.35.1.16

Cited by 32 publications

(7 citation statements)

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“…Furthermore, DA receptors are abundantly expressed in brain areas known to be damaged after TBI, such as the frontal cortex and striatum, which are important for cognitive function (Seeman et al, 1978; Baron et al, 1985; McDonald et al, 2002; Chudasama and Robbins, 2006). The hippocampus, which is also critical for cognitive function does not have a high level of DA receptor expression, but is dependent on DA activity to modulate function (Lemon and Manahan-Vaughan, 2006; O'Carroll et al, 2006; Granado et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis

Bales

Wagner

Kline

et al. 2009

Neuroscience & Biobehavioral Reviews

221

190

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Traumatic brain injury (TBI) represents a significant cause of death and disability in industrialized countries. Of particular importance to patients the chronic effect that TBI has on cognitive function. Therapeutic strategies have been difficult to evaluate because of the complexity of injuries and variety of patient presentations within a TBI population. However, pharmacotherapies targeting dopamine (DA) have consistently shown benefits in attention, behavioral outcome, executive function, and memory. Still it remains unclear what aspect of TBI pathology is targeted by DA therapies and what time-course of treatment is most beneficial for patient outcomes. Fortunately, ongoing research in animal models has begun to elucidate the pathophysiology of DA alterations after TBI. The purpose of this review is to discuss clinical and experimental research examining DAergic therapies after TBI, which will in turn elucidate the importance of DA for cognitive function/dysfunction after TBI as well as highlight the areas that require further study.

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Section: Introductionmentioning

confidence: 99%

Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis

Bales

Wagner

Kline

et al. 2009

Neuroscience & Biobehavioral Reviews

221

190

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“…For these PET applications in human subjects, [ 11 C]raclopride or radiolabeled analogs of spiperone have been commonly used [9].…”

Section: Introductionmentioning

confidence: 99%

Validation of the reference tissue model for estimation of dopaminergic D2-like receptor binding with [18F](N-methyl)benperidol in humans

Antenor-Dorsey

Markham

Moerlein

et al. 2008

Nuclear Medicine and Biology

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PET measurements of dopaminergic D 2 -like receptors may provide important insights into disorders such as Parkinson's disease, schizophrenia, dystonia and Tourette's syndrome. The PET radioligand [ 18 F] (N-Methyl)Benperidol ([ 18 F]-NMB) has high affinity and selectivity for D 2 -like receptors and is not displaced by endogenous dopamine. The goal of this study is to evaluate use of a graphical method utilizing a reference tissue region for ([ 18 F]-NMB PET analysis by comparisons to an explicit three-compartment tracer kinetic model and graphical method that use arterial blood measurements. We estimated binding potential (BP) in the caudate and putamen using all three methods in 16 humans and found that the three-compartment tracer kinetic method provided the highest BP estimates while the graphical method using a reference region yielded the lowest estimates (p<0.0001 by repeated measures ANOVA). However, the three methods yielded highly correlated BP estimates for the two regions of interest. We conclude that the graphical method using a reference region still provides a useful estimate of BP comparable to methods using arterial blood sampling, especially since the reference region method is less invasive and computationally more straightforward; thereby simplifying these measurements.

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“…Characterization of dopaminergic receptors in the living human brain has recently become possible by means of positroc emission tomography (PET) and single photon emission computed tomography (SPECT). The dopaminergic system can be visualized by short-lived radionuclides combined in different drugs to form pre-and postsynaptic markers, for example "C-N-methyl-spiperone ("C-NMSP) (l), 77Br-p-bromo-spiperone (2), 18F-6-fluoro-Ldopa (3) "C-pimozide (4) and "C-raclopride (5).…”

mentioning

confidence: 99%

Dopamine receptor properties in Parkinson's disease and Huntington's chorea evaluated by positron emission tomography using¹¹C-N-methyl-spiperone

Hägglund¹,

Sm²,

Sa³

et al. 1987

Acta Neurologica Scandinavica

106

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Dopaminergic receptor properties in the striatum of patients with Parkinson's disease (PD) and Huntington's chorea (HD) were studied by positron emission tomography (PET), using 11C-N-methyl-spiperone as a dopamine D2 receptor ligand. The time-dependent regional radioactive uptake in the caudate nucleus and the putamen was measured and fitted to a 3-compartment pharmacokinetic model. The rate constant k3 for specific binding to the receptor compartment in the striatum was determined in relation to the binding in regions with a low density of specific binding sites, such as the cerebellum and the frontal cortex . k3, which is a measure of the receptor density, was reduced in one patient with HD but less affected in PD in comparison with healthy controls. The pattern of k3 values calculated from the 6 PD patients is discussed in relation to any side-to-side differences in dopamine receptor densities in hemiparkinsonism and to possible "hypersensitivity" of dopamine receptors in the early stage of the disease and down-regulation in more advanced disease.

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Dopaminergic receptor sites in human brain

Cited by 32 publications

References 0 publications

Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis

Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis

Validation of the reference tissue model for estimation of dopaminergic D2-like receptor binding with [18F](N-methyl)benperidol in humans

Dopamine receptor properties in Parkinson's disease and Huntington's chorea evaluated by positron emission tomography using¹¹C-N-methyl-spiperone

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Dopaminergic receptor sites in human brain

Cited by 32 publications

References 0 publications

Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis

Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis

Validation of the reference tissue model for estimation of dopaminergic D2-like receptor binding with [18F](N-methyl)benperidol in humans

Dopamine receptor properties in Parkinson's disease and Huntington's chorea evaluated by positron emission tomography using11C-N-methyl-spiperone

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Dopamine receptor properties in Parkinson's disease and Huntington's chorea evaluated by positron emission tomography using¹¹C-N-methyl-spiperone