Dopaminergic projection from nucleus raphe dorsalis to neostriatum in the rat

Descarries, Laurent; Berthelet, France; Garcia, Sylvia; Beaudet, Alain

doi:10.1002/cne.902490407

Cited by 88 publications

(42 citation statements)

References 54 publications

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Section: Nih Public Accessmentioning

confidence: 99%

“…Anterograde tracing studies with Phaseolus vulgaris leucoagglutinin (PHA-L) or biotinylated dextran amine (BDA) have demonstrated that regions of the basal forebrain are heavily targeted by DRN projections (Vertes, 1991;Sim and Joseph, 1993;Morin and Meyer-Bernstein, 1999), and retrograde tracing has confirmed that this projection arises, in part, from nonserotonergic neurons (Descarries et al, 1986;Semba et al, 1988;Stratford and Wirtshafter, 1990;Li et al, 1990; Van Bockstaele et al, 1993;Petrov et al, 1994;Ford et al, 1995;Gasbarri et al, 1999; Hansue and Shammah-Lagnado, 2002;Halberstadt and Balaban, 2006a). A recent study combined BDA anterograde tracing with 5-HT-immunofluorescent staining to demonstrate that the vast majority of DRN fibers innervating the septum are nonserotonergic (Aznar et al, 2004).…”

Section: Nih Public Accessmentioning

confidence: 99%

“…Experiments combining retrograde tracing with serotonin (5-HT) immunostaining have established that many nonserotonergic DRN neurons project extrinsically (Beitz et al, 1986;Ma et al, 1991;Petrov et al, 1992Petrov et al, , 1994 Van Bockstaele et al, 1993;Kirifides et al, 2001;Kim et al, 2004;Halberstadt and Balaban, 2006a). Nonserotonergic DRN projections are neurochemically heterogeneous, and may contain a number of transmitter substances, including glutamate (Schwarz and Schwarz, 1992;Kiss et al, 2002), dopamine (Pohle et al, 1984;Descarries et al, 1986;Yoshida et al, 1989;Stratford and Wirtshafter, 1990;Hasue and Shammah-Lagnado, 2002), GABA (Nanopoulos et al, 1982;Stamp and Semba, 1995;Ford et al, 1995;Jankowski and Sesack, 2002), nitric oxide (Xu and Hokfelt, 1997;Simpson et al, 2003), and neuropeptides such as vasoactive intestinal polypeptide (VIP) (Petit et al, 1995;Kozicz et al, 1998) and cholecystokinin Seroogy and Fallon, 1989).Although it is likely that non-5-HT DRN projections influence processing in target regions (Weiss and Pellet, 1982;Hajés-Korcsok and Sharp, 2002), very little is known about the anatomical organization of this pathway. Anterograde tracing studies with Phaseolus vulgaris leucoagglutinin (PHA-L) or biotinylated dextran amine (BDA) have demonstrated that regions of the basal forebrain are heavily targeted by DRN projections (Vertes, 1991;Sim and Joseph, 1993;Morin and Meyer-Bernstein, 1999), and retrograde tracing has confirmed that this projection arises, in part, from nonserotonergic neurons (Descarries et al, 1986;Semba et al, 1988;Stratford and Wirtshafter, 1990;…”

mentioning

confidence: 99%

“…Nonserotonergic DRN projections are neurochemically heterogeneous, and may contain a number of transmitter substances, including glutamate (Schwarz and Schwarz, 1992;Kiss et al, 2002), dopamine (Pohle et al, 1984;Descarries et al, 1986;Yoshida et al, 1989;Stratford and Wirtshafter, 1990;Hasue and Shammah-Lagnado, 2002), GABA (Nanopoulos et al, 1982;Stamp and Semba, 1995;Ford et al, 1995;Jankowski and Sesack, 2002), nitric oxide (Xu and Hokfelt, 1997;Simpson et al, 2003), and neuropeptides such as vasoactive intestinal polypeptide (VIP) (Petit et al, 1995;Kozicz et al, 1998) and cholecystokinin Seroogy and Fallon, 1989).…”

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confidence: 99%

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Selective anterograde tracing of nonserotonergic projections from dorsal raphe nucleus to the basal forebrain and extended amygdala

Halberstadt

Balaban

2008

Journal of Chemical Neuroanatomy

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The dorsal raphe nucleus (DRN) contains both serotonergic and non-serotonergic projection neurons. Retrograde tracing studies have demonstrated that components of the basal forebrain and extended amygdala are targeted heavily by input from nonserotonergic DRN neurons. The object of this investigation was to examine the terminal distribution of nonserotonergic DRN projections in the basal forebrain and extended amygdala, using a technique that allows selective anterograde tracing of nonserotonergic DRN projections. To trace nonserotonergic DRN projections, animals were pretreated with nomifensine, desipramine and the serotonergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT), 7 days prior to placing an iontophoretic injection of biotinylated dextran amine (BDA) into the DRN. In animals treated with 5,7-DHT, numerous nonserotonergic BDA-labeled fibers ascended to the basal forebrain in the medial forebrain bundle system. Some of these labeled fibers crossed through the lateral hypothalamus, bed nucleus of the stria terminalis, and substantial innominata. These fibers entered the amygdala through the ansa peduncularis and ramified within the central and basolateral amygdaloid nuclei. Other fibers entered the diagonal band of Broca and formed a dense plexus of labeled fibers in the dorsal half of the intermediate portion of the lateral septal nucleus and the septohippocampal nucleus. These findings demonstrate that the basal forebrain and extended amygdala receive a dense projection from nonserotonergic DRN neurons. Given that the basal forebrain plays a critical role in processes such as motivation, affect, and behavioral control, these findings support the hypothesis that nonserotonergic DRN projections may exert substantial modulatory control over emotional and motivational functions. Keywords amygdala; bed nucleus; 5,7-dihydroxytryptamine; septal nuclei; biotinylated dextran amine; tyrosine hydroxylase It is well known that the dorsal raphe nucleus contains more than half of all the serotonergic neurons in the brain (Leger and Wiklund, 1982) and is a source of projections that terminate extensively throughout the central nervous system (Vertes, 1991;Sim and Joseph, 1993;Vertes and Kocsis, 1994;Morin and Meyer-Bernstein, 1999 Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. within dorsomedial (DRNdm), ventromedial (DRNvm), and lateral (DRNl) cell groups . It has been proposed that the activity of serotonergic DRN neurons plays an important role in the coordination of sensory processing and motor output with the sleep-wake-arousal cycle (Jacobs and Azmitia, 1992; Forn...

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Section: Nih Public Accessmentioning

confidence: 99%

Section: Nih Public Accessmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Selective anterograde tracing of nonserotonergic projections from dorsal raphe nucleus to the basal forebrain and extended amygdala

Halberstadt

Balaban

2008

Journal of Chemical Neuroanatomy

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“…This cell group extends rostrocaudally for a little more than 0.5 mm, occupying the rostral third of this nucleus as defined by its content in 5HT neurons (Descarries et al, 1986). It begins rostral at the level of the oculomotor nucleus and reaches its greatest dimension at level A-770, and reduce abruptly at level A-470 (Steinbusch et al, 1980).…”

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confidence: 96%

Ascending projections of the dorsal raphe nucleus to the caudate-putamen complex in rat: A degeneration and anterograde tracing study

Jahanshahi¹,

Temel²,

Steinbusch³

2012

jecm

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Studies on neuropathological processes underlying the clinical syndromes of Parkinson's disease (PD) have confirmed that PD affects both dopaminergic as well as serotonergic projections of the dorsal raphe nucleus (DRN). These projections were investigated in the present study, using neurochemical lesion and anterograde tracing techniques. One of the suggested mechanisms responsible for the progressive loss of dopamine (DA) in PD is the oxidative stress-induced degeneration. The free radical nitric oxide (NO) appears to be of special interest. The presence of this molecule in both the serotonergic and dopaminergic DRN projections to the Caudate-Putamen (CPu) was examined in the present study, using a combined neurochemical lesion technique and NADPH-d histochemistry. NO and serotonin were found to be colocalized in the dorsomedial cluster of the DRN. However, no NOS-immunohistochemistry was detected in the serotonergic raphe-striatal projections. Loss of serotonergic neurons in the ventromedial dorsal raphe resulted in a reduction of the striatal dopaminergic innervation. Degenerating serotonergic elements were observed at both ends of the nigrostriatal pathway. Furthermore, loss of DA-immunoreactivity in the DRN was observed to be concomitant with an enhanced degeneration of the raphe cells. Serotonergic raphe neurons may therefore be inhibited by dopaminergic input of the DRN originating in the substantia nigra. Loss of this inhibition might augment the hypothesized degeneration of the serotonergic raphe-striatal projections in PD. Malfunction of such a feedback system could be a possible cause of the DA deficiency in PD.

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Early neuromeric distribution of tyrosine-hydroxylase-immunoreactive neurons in human embryos

1998

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A segmental mapping of brain tyrosine-hydroxylase-immunoreactive (TH-IR) neurons in human embryos between 4.5 and 6 weeks of gestation locates with novel precision the dorsoventral and anteroposterior topography of the catecholamine-synthetizing primordia relative to neuromeric units. The data support the following conclusions. (1) All transverse sectors of the brain (prosomeres in the forebrain, midbrain, rhombomeres in the hindbrain, spinal cord) produce TH-IR neuronal populations. (2) Each segment shows peculiarities in its contribution to the catecholamine system, but there are some overall regularities, which reflect that some TH-IR populations develop similarly in different segments. (3) Dorsoventral topology of the TH-IR neurons indicates that at least four separate longitudinal zones (in the floor and basal plates and twice in the alar plate) found across most segments are capable of producing the TH-IR phenotype. (4) Basal plate TH-IR neurons tend to migrate intrasegmentally to a ventrolateral superficial position, although some remain periventricular; those in the brainstem are related to motoneurons of the oculomotor and branchiomotor nuclei. (5) Some alar TH-IR populations migrate superficially within the segmental boundaries. (6) Most catecholaminergic anatomical entities are formed as fusions of smaller segmental components, each of which show similar histogenetic patterns. A nomenclature is proposed that partly adheres to previous terminology but introduces the distinction of embryologically different cell populations and unifies longitudinally analogous entities. Such a model, as presented in the present study, is convenient for resolving problems of homology of the catecholamine system across the diversity of vertebrate forms.

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Dopaminergic projection from nucleus raphe dorsalis to neostriatum in the rat

Cited by 88 publications

References 54 publications

Selective anterograde tracing of nonserotonergic projections from dorsal raphe nucleus to the basal forebrain and extended amygdala

Selective anterograde tracing of nonserotonergic projections from dorsal raphe nucleus to the basal forebrain and extended amygdala

Ascending projections of the dorsal raphe nucleus to the caudate-putamen complex in rat: A degeneration and anterograde tracing study

Early neuromeric distribution of tyrosine-hydroxylase-immunoreactive neurons in human embryos

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