Dopaminergic neurotransmission in ventral and dorsal striatum differentially modulates alcohol reinforcement

Spoelder, Marcia; Hesseling, Peter; Styles, Matthew; Baars, Annemarie M.; Klooster, José G. Lozeman-van ‘t; Lesscher, Heidi M. B.; Vanderschuren, Louk J. M. J.

doi:10.1111/ejn.13358

Cited by 11 publications

(9 citation statements)

References 88 publications

(122 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, across the literature, lower SB doses seem to suppress behavior involving other putative high-motivation states, including nicotine intake [181] and alcohol drinking in genetically-preferring rats [164]. Additionally, the NAcb shell [150,182] and Ox1Rs [183] regulate several types of compulsion-like behaviors, and the former is also a region where lower dose receptor inhibition can impact highereffort responding (progressive ratio), while higher antagonist doses are required to reduce lower-effort responding [184,185]. Thus, our interest in the NAcb shell as a regulator of compulsion-like drinking in both sexes remains.…”

Section: Systemic Test Of Orexin Receptor Regulation Of Binge and Compulsion-like Alcohol Drinkingmentioning

confidence: 99%

Recent Perspectives on Sex Differences in Compulsion-Like and Binge Alcohol Drinking

Radke

Sneddon

Frasier

et al. 2021

IJMS

View full text Add to dashboard Cite

Alcohol use disorder remains a substantial social, health, and economic problem and problem drinking levels in women have been increasing in recent years. Understanding whether and how the underlying mechanisms that drive drinking vary by sex is critical and could provide novel, more targeted therapeutic treatments. Here, we examine recent results from our laboratories and others which we believe provide useful insights into similarities and differences in alcohol drinking patterns across the sexes. Findings for binge intake and aversion-resistant, compulsion-like alcohol drinking are considered, since both are likely significant contributors to alcohol problems in humans. We also describe studies regarding mechanisms that may underlie sex differences in maladaptive alcohol drinking, with some focus on the importance of nucleus accumbens (NAcb) core and shell regions, several receptor types (dopamine, orexin, AMPA-type glutamate), and possible contributions of sex hormones. Finally, we discuss how stressors such as early life stress and anxiety-like states may interact with sex differences to contribute to alcohol drinking. Together, these findings underscore the importance and critical relevance of studying female and male mechanisms for alcohol and co-morbid conditions to gain a true and clinically useful understanding of addiction and neuropsychiatric mechanisms and treatment.

show abstract

Section: Systemic Test Of Orexin Receptor Regulation Of Binge and Compulsion-like Alcohol Drinkingmentioning

confidence: 99%

Recent Perspectives on Sex Differences in Compulsion-Like and Binge Alcohol Drinking

Radke

Sneddon

Frasier

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Interestingly, whereas inactivation of the DMS prevented the expression of an ethanol devaluation effect following 2 weeks of training, this manipulation was ineffective after 8 weeks of training when inactivation of the DLS restored sensitivity to devaluation 56 . Altogether, it is tempting to speculate that the higher motivation to consume ethanol in sensitized mice (compared with resistant mice) may be associated with habit learning processes and the abnormal response of the DLS that has also a well‐known role in incentive motivation 57 . It could be interesting to test in a future work whether targeting the DLS with lesions, denervation, or pharmacological inactivation could have an impact on the increased motivation for ethanol intake in sensitized mice.…”

Section: Discussionmentioning

confidence: 99%

Vulnerability to ethanol sensitization predicts higher intake and motivation to self‐administer ethanol: Proof of the incentive salience sensitization theory?

2019

View full text Add to dashboard Cite

Ethanol-induced behavioral sensitization (EIBS) is thought to play a key role in addiction. However, whether EIBS is linked to an increase in the motivation to selfadministerethanol in an operant paradigm has never been demonstrated, and thus, the motivational sensitization theory (increase in drug wanting) has not been yet confirmed. We investigated using the operant ethanol self-administrationparadigm if the motivation to self-administerethanol (breakpoint) is increased in female mice prone to develop EIBS. Outbred female Swiss mice were treated once a day with 2.5-g ethanol per kilogram during 10 days and challenged with the same dose of ethanol 7 days later. EIBS-pronegroup was characterized by a significant increase in locomotion between the challenge day and day 1. When the difference was not significant, mice were considered as the "EIBS-resistant"group. Mice were then trained to nose poke for a 20% ethanol solution reinforcer under a FR1 and then a FR-2schedule of reinforcement. Motivation was assessed more directly with a progressive ratio schedule. Our results show that there is a positive correlation between EIBS and both the level of intake and motivation. Interestingly, acquisition of ethanol self-administrationwas faster in sensitized mice that also display a quick and long-lastingincrease in ethanol intake together with a lack of effect of alcohol challenge on c-Fosexpression restricted to the dorsolateral striatum. These results further support that EIBS vulnerability is crucial in the development of addictive behaviors and suggest a potential link with habit learning processes.

show abstract

“…The reason is that this slice contains the enlarged ventricle and the shrunk gray matter caused by alcoholism. On the contrary, hippocampus [36] and striatum [37] are also related to alcoholism. Nevertheless, their altered volumes are relatively small and hence do not provide an excellent performance in this task.…”

Section: Validation Of the Selected Slicementioning

confidence: 96%

Identification of Alcoholism Based on Wavelet Renyi Entropy and Three‐Segment Encoded Jaya Algorithm

Wang

Muhammad

et al. 2018

Complexity

View full text Add to dashboard Cite

The alcohol use disorder (AUD) is an important brain disease, which could cause the damage and alteration of brain structure. The current diagnosis of AUD is mainly done manually by radiologists. This study proposes a novel computer-vision-based method for automatic detection of AUD based on wavelet Renyi entropy and three-segment encoded Jaya algorithm from MRI scans. The wavelet Renyi entropy is proposed to provide multiresolution and multiscale analysis of features, describe the complexity of the brain structure, and extract the distinctive features. Grid search method was used to select the optimal wavelet decomposition level and Renyi order. The classifier was constructed based on feedforward neural network and a three-segment encoded (TSE) Jaya algorithm providing parameter-free training of the weights, biases, and number of hidden neurons. We have conducted the experimental evaluation on 235 subjects (114 are AUDs and 121 healthy). -fold cross validation has been used to avoid overfitting and report out-of-sample errors. The results showed that the proposed method outperforms four state-of-the-art approaches in terms of accuracy. The proposed TSE-Jaya provides a better performance, compared to the conventional approaches including plain Jaya, multiobjective genetic algorithm, particle swarm optimization, bee colony optimization, modified ant colony system, and real-coded biogeography-based optimization.

show abstract

Dopaminergic neurotransmission in ventral and dorsal striatum differentially modulates alcohol reinforcement

Cited by 11 publications

References 88 publications

Recent Perspectives on Sex Differences in Compulsion-Like and Binge Alcohol Drinking

Recent Perspectives on Sex Differences in Compulsion-Like and Binge Alcohol Drinking

Vulnerability to ethanol sensitization predicts higher intake and motivation to self‐administer ethanol: Proof of the incentive salience sensitization theory?

Identification of Alcoholism Based on Wavelet Renyi Entropy and Three‐Segment Encoded Jaya Algorithm

Contact Info

Product

Resources

About