Dopaminergic Modulation of Spiny Neurons in the Turtle Striatum

Barral, Jaime; Galarraga, Elvira; Tapia, Dagoberto; Flores-Barrera, Edén; Reyes, Alfonso; Bargas, José

doi:10.1007/s10571-010-9499-7

Cited by 11 publications

(10 citation statements)

References 54 publications

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“…In the present study we observed a marked reduction of discharge in lamprey striatal neurons upon D2 receptor activation, a finding that is consistent with results from reptiles, birds and mammals [31], [32], [48]. The D2 receptor agonist, TNPA, shifted the threshold to more depolarized levels for both action potentials and PIR spikes, as well as reducing their amplitudes.…”

Section: Discussionsupporting

confidence: 92%

“…In mammals and birds, selective activation of D2 receptors reduces the overall excitability of striatal projection and interneurons through modulation of intrinsic and synaptic properties [12], [31], [32]. To investigate the effects of D2 receptor activation on lamprey striatal neurons, we applied the selective D2 agonist, TNPA, during whole cell current-clamp recordings.…”

Section: Resultsmentioning

confidence: 99%

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The Dopamine D2 Receptor Gene in Lamprey, Its Expression in the Striatum and Cellular Effects of D2 Receptor Activation

et al. 2012

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All basal ganglia subnuclei have recently been identified in lampreys, the phylogenetically oldest group of vertebrates. Furthermore, the interconnectivity of these nuclei is similar to mammals and tyrosine hydroxylase-positive (dopaminergic) fibers have been detected within the input layer, the striatum. Striatal processing is critically dependent on the interplay with the dopamine system, and we explore here whether D2 receptors are expressed in the lamprey striatum and their potential role. We have identified a cDNA encoding the dopamine D2 receptor from the lamprey brain and the deduced protein sequence showed close phylogenetic relationship with other vertebrate D2 receptors, and an almost 100% identity within the transmembrane domains containing the amino acids essential for dopamine binding. There was a strong and distinct expression of D2 receptor mRNA in a subpopulation of striatal neurons, and in the same region tyrosine hydroxylase-immunoreactive synaptic terminals were identified at the ultrastructural level. The synaptic incidence of tyrosine hydroxylase-immunoreactive boutons was highest in a region ventrolateral to the compact layer of striatal neurons, a region where most striatal dendrites arborise. Application of a D2 receptor agonist modulates striatal neurons by causing a reduced spike discharge and a diminished post-inhibitory rebound. We conclude that the D2 receptor gene had already evolved in the earliest group of vertebrates, cyclostomes, when they diverged from the main vertebrate line of evolution (560 mya), and that it is expressed in striatum where it exerts similar cellular effects to that in other vertebrates. These results together with our previous published data (Stephenson-Jones et al. 2011, 2012) further emphasize the high degree of conservation of the basal ganglia, also with regard to the indirect loop, and its role as a basic mechanism for action selection in all vertebrates.

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Section: Discussionsupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

The Dopamine D2 Receptor Gene in Lamprey, Its Expression in the Striatum and Cellular Effects of D2 Receptor Activation

et al. 2012

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“…The former are of two subtypes expressing substance P or enkephalin, respectively. They are similar to the mammalian, avian and reptile spiny projection neurons (Kawaguchi et al 1989;Farries & Perkel, 2000;Farries et al 2005;Barral et al 2010), and project to the lamprey homologues of the globus pallidus and substantia nigra pars reticulata (Stephenson-Jones et al 2011, 2012.…”

Section: Introductionmentioning

confidence: 90%

“…1989; Farries & Perkel, 2000; Farries et al . 2005; Barral et al . 2010), and project to the lamprey homologues of the globus pallidus and substantia nigra pars reticulata (Stephenson‐Jones et al .…”

Section: Introductionmentioning

confidence: 99%

Evolutionarily conserved differences in pallial and thalamic short‐term synaptic plasticity in striatum

Ericsson

Stephenson-Jones

Kardamakis

et al. 2012

The Journal of Physiology

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Key points• Recent studies have shown that the striatum and the basal ganglia are to a remarkable degree conserved throughout the vertebrate phylum.• As the basic organization of the neural machinery for action selection is present in the lamprey, it is essential to understand how the striatum is activated.• In this study we characterize the pharmacology and synaptic dynamics from the lateral pallium (LPal; cortex) and thalamus (Th), the main excitatory input to the striatum.• We show that, as in mammals, the LPal and Th provide glutamatergic excitation to the striatum, but with completely opposite short-term synaptic plasticity due to differences in presynaptic properties.• These synaptic differences are also characteristic of the mammalian striatum, suggesting that these are fundamental components of the vertebrate mechanisms for action selection.Abstract The striatum of the basal ganglia is conserved throughout the vertebrate phylum. Tracing studies in lamprey have shown that its afferent inputs are organized in a manner similar to that of mammals. The main inputs arise from the thalamus (Th) and lateral pallium (LPal; the homologue of cortex) that represents the two principal excitatory glutamatergic inputs in mammals. The aim here was to characterize the pharmacology and synaptic dynamics of afferent fibres from the LPal and Th onto identified striatal neurons to understand the processing taking place in the lamprey striatum. We used whole-cell current-clamp recordings in acute slices of striatum with preserved fibres from the Th and LPal, as well as tract tracing and immunohistochemistry. We show that the Th and LPal produce monosynaptic excitatory glutamatergic input through NMDA and AMPA receptors. The synaptic input from the LPal displayed short-term facilitation, unlike the Th input that instead displayed strong short-term synaptic depression. There was also an activity-dependent recruitment of intrastriatal oligosynaptic inhibition from both inputs. These results indicate that the two principal inputs undergo different activity-dependent short-term synaptic plasticity in the lamprey striatum. The difference observed between Th and LPal (cortical) input is also observed in mammals, suggesting a conserved trait throughout vertebrate evolution.

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“…The dopamine‐immunoreactive (DA‐IR) neurons and their projection fibers were studied in the cerebellum of various mammals and nonmammalian vertebrates, such as the cat (Nieoullon et al, ), the rat (Panagopoulos et al, ; Ikai et al, ), and the European eel (Roberts et al, ). In the central nervous systems of the reptiles, DA‐IR neurons and fibers were reported in the adult tortoise Geochelone chilensis (Juorio, ), the red‐eared turtle (Smeets et al, ), the turtle Trachemys scripta (Milton and Lutz, ; Barral et al, ), the snake Python regius (Smeets, ), and the lizard Gekko gecko (Russchen et al, ; Stoof et al, ; Smeets et al, ), the lizard Gallotia galloti (Medina et al, ). However, although there were few studies about the distribution of DA in the central nervous systems of reptiles, there were no reports about the DA in the cerebellum of the Yangtze alligator.…”

Section: Introductionmentioning

confidence: 99%

5‐Hydroxytryptamine and Dopamine Neurons in the Cerebellum of the New‐Hatching Yangtze AlligatorAlligator sinensis

Ren

Chen

Yang

et al. 2018

The Anatomical Record

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Nissl and immunohistochemical staining methods were used to morphologically characterize the cerebellum of the new‐hatching Yangtze alligator, and the cerebellar histological structure and the distribution profiles of 5‐hydroxytryptamine (5‐HT) and dopamine (DA) neurons were investigated for the first time. The results of cerebellar histological structure showed that there was a ventriculus cerebelli in the cerebellum of the new‐hatching Yangtze alligator, the surface of the cerebellar cortex was not very smooth, the cerebellar cortex could be divided into four layers, which include external granular layer, molecular layer, Purkinje cell layer and granular layer, Purkinje cell layer could be characterized specially by multilayer, two cerebellar nuclei termed as the nucleus cerebelli lateralis and the nucleus cerebelli medialis were found in the cerebellar medulla. 5‐hydroxytryptamine‐immunoreactive (5‐HT‐IR) and dopamine‐immunoreactive (DA‐IR) neurons and fibers distributed widely in the cerebellum. The structures and profiles of 5‐HT‐IR and DA‐IR neurons and fibers in the cerebellum of the Yangtze alligator were similar to that reported in other reptiles, but also had some specific features. The abundance of 5‐HT and DA in cerebellum suggested that these highly conserved neurotransmitters would play important roles in motor control. Anat Rec, 302:861–868, 2019. © 2018 Wiley Periodicals, Inc.

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Dopaminergic Modulation of Spiny Neurons in the Turtle Striatum

Cited by 11 publications

References 54 publications

The Dopamine D2 Receptor Gene in Lamprey, Its Expression in the Striatum and Cellular Effects of D2 Receptor Activation

The Dopamine D2 Receptor Gene in Lamprey, Its Expression in the Striatum and Cellular Effects of D2 Receptor Activation

Evolutionarily conserved differences in pallial and thalamic short‐term synaptic plasticity in striatum

5‐Hydroxytryptamine and Dopamine Neurons in the Cerebellum of the New‐Hatching Yangtze AlligatorAlligator sinensis

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