Dopaminergic medication boosts action–effect binding in Parkinson's disease

Moore, James W.; Schneider, Susanne A.; Schwingenschuh, Petra; Moretto, Giovanna; Bhatia, Kailash P.; Haggard, Patrick

doi:10.1016/j.neuropsychologia.2009.12.014

Cited by 77 publications

(98 citation statements)

References 60 publications

(41 reference statements)

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“…Here, it is harder to rule out remote effects. One recent study showed intact intentional binding in patients with Parkinson's disease (Moore et al 2010). BG dysfunction in Parkinson's disease, and putative disruption of BG function by remote effects of cTBS over pre-SMA, are clearly not strictly equivalent.…”

Section: (A) Limitationsmentioning

confidence: 99%

Disrupting the experience of control in the human brain: pre-supplementary motor area contributes to the sense of agency

et al. 2010

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The feeling of controlling events through one's actions is fundamental to human experience, but its neural basis remains unclear. This 'sense of agency' (SoA) can be measured quantitatively as a temporal linkage between voluntary actions and their external effects. We investigated the brain areas underlying this aspect of action awareness by using theta-burst stimulation to locally and reversibly disrupt human brain function. Disruption of the pre-supplementary motor area (pre-SMA), a key structure for preparation and initiation of a voluntary action, was shown to reduce the temporal linkage between a voluntary key-press action and a subsequent electrocutaneous stimulus. In contrast, disruption of the sensorimotor cortex, which processes signals more directly related to action execution and sensory feedback, had no significant effect. Our results provide the first direct evidence of a pre-SMA contribution to SoA.

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Section: (A) Limitationsmentioning

confidence: 99%

Disrupting the experience of control in the human brain: pre-supplementary motor area contributes to the sense of agency

et al. 2010

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“…The errors were calculated by the difference between perceived and actual moments of time. Following this, the intentional binding is calculated through the formulas shown in Figure 3 [46]. As shown in Figure 3, in baseline conditions participants perceived the action earlier but the outcome later when compared to the actual time.…”

Section: The Intentional Binding Paradigmmentioning

confidence: 99%

Agency in Mid-air Interfaces

Cornelio

Pirro

Thanh

et al. 2017

Proceedings of the 2017 CHI Conference on Human Factors in Computing Systems

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Touchless interfaces allow users to view, control and manipulate digital content without physically touching an interface. They are being explored in a wide range of application scenarios from medical surgery to car dashboard controllers. One aspect of touchless interaction that has not been explored to date is the Sense of Agency (SoA). The SoA refers to the subjective experience of voluntary control over actions in the external world. In this paper, we investigated the SoA in touchless systems using the intentional binding paradigm. We first compare touchless systems with physical interactions and then augmented different types of haptic feedback to explore how different outcome modalities influence users' SoA.From our experiments, we demonstrated that an intentional binding effect is observed in both physical and touchless interactions with no statistical difference. Additionally, we found that haptic and auditory feedback help to increase SoA compared with visual feedback in touchless interfaces. We discuss these findings and identify design opportunities that take agency into consideration.

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“…The principal measures include binding of action (the delay in the perception of action and its attraction towards the time of tone) and binding of tone (the earlier perception of tone and its attraction towards the time of action) (Haggard et al, 2002). One can also examine “composite” binding, in terms of the sum of action binding and tone binding (Moore et al, 2010b; Moore and Obhi, 2012), although there are caveats to this approach (see below).…”

Section: Intentional Binding: Objective Chronometry In the Study Of Amentioning

confidence: 99%

Beyond the â€œurge to moveâ€: objective measures for the study of agency in the post-Libet era

Wolpe

Rowe

2014

Front. Hum. Neurosci.

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The investigation of human volition is a longstanding endeavor from both philosophers and researchers. Yet because of the major challenges associated with capturing voluntary movements in an ecologically relevant state in the research environment, it is only in recent years that human agency has grown as a field of cognitive neuroscience. In particular, the seminal work of Libet et al. (1983) paved the way for a neuroscientific approach to agency. Over the past decade, new objective paradigms have been developed to study agency, drawing upon emerging concepts from cognitive and computational neuroscience. These include the chronometric approach of Libet’s study which is embedded in the “intentional binding” paradigm, optimal motor control theory and most recent insights from active inference theory. Here we review these principal methods and their application to the study of agency in health and the insights gained from their application to neurological and psychiatric disorders. We show that the neuropsychological paradigms that are based upon these new approaches have key advantages over traditional experimental designs. We propose that these advantages, coupled with advances in neuroimaging, create a powerful set of tools for understanding human agency and its neurobiological basis.

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Dopaminergic medication boosts action–effect binding in Parkinson's disease

Cited by 77 publications

References 60 publications

Disrupting the experience of control in the human brain: pre-supplementary motor area contributes to the sense of agency

Disrupting the experience of control in the human brain: pre-supplementary motor area contributes to the sense of agency

Agency in Mid-air Interfaces

Beyond the â€œurge to moveâ€: objective measures for the study of agency in the post-Libet era

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Dopaminergic medication boosts action–effect binding in Parkinson's disease

Cited by 77 publications

References 60 publications

Disrupting the experience of control in the human brain: pre-supplementary motor area contributes to the sense of agency

Disrupting the experience of control in the human brain: pre-supplementary motor area contributes to the sense of agency

Agency in Mid-air Interfaces

Beyond the â€œurge to moveâ€: objective measures for the study of agency in the post-Libet era

Contact Info

Product

Resources

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Beyond the â€œurge to moveâ€: objective measures for the study of agency in the post-Libet era