Dopaminergic dysfunction in tourette syndrome

Singer, Harvey S.; Butler, Ian J.; Tune, Larry E.; Seifert, William E.; Coyle, Joseph T.

doi:10.1002/ana.410120408

Cited by 167 publications

(66 citation statements)

References 25 publications

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“…Higher scores indicate worsening phenotype. including the measurement of homovanilic acid levels in post-mortem studies (Butler et al, 1979;Singer et al, 1982), it appears that the most direct evidence has been the strikingly consistent increase in AMP-induced DA rel that was first shown via PET imaging in the pilot study mentioned above (Singer et al, 2002). Improved tomographic resolution has allowed us to examine specific subdivisions of the striatum and, in the current study, we have observed significantly elevated AMP-induced DA rel in the ventral striatum.…”

Section: Discussionsupporting

confidence: 63%

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Mechanisms of Dopaminergic and Serotonergic Neurotransmission in Tourette Syndrome: Clues from an In Vivo Neurochemistry Study with PET

Wong

Brašić

Singer

et al. 2007

Neuropsychopharmacol

231

172

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Tourette syndrome (TS) is a neuropsychiatric disorder with childhood onset characterized by motor and phonic tics. Obsessivecompulsive disorder (OCD) is often concomitant with TS. Dysfunctional tonic and phasic dopamine (DA) and serotonin (5-HT) metabolism may play a role in the pathophysiology of TS. We simultaneously measured the density, affinity, and brain distribution of dopamine D 2 receptors (D 2 -R's), dopamine transporter binding potential (BP), and amphetamine-induced dopamine release (DA rel ) in 14 adults with TS and 10 normal adult controls. We also measured the brain distribution and BP of serotonin 5-HT 2A receptors (5-HT 2A R), and serotonin transporter (SERT) BP, in 11 subjects with TS and 10 normal control subjects. As compared with controls, DA rel was significantly increased in the ventral striatum among subjects with TS. Adults with TS + OCD exhibited a significant D 2 -R increase in left ventral striatum. SERT BP in midbrain and caudate/putamen was significantly increased in adults with TS (TS + OCD and TS-OCD). In three subjects with TS + OCD, in whom D 2 -R, 5-HT 2A R, and SERT were measured within a 12-month period, there was a weakly significant elevation of DA rel and 5-HT 2A BP, when compared with TS-OCD subjects and normal controls. The current study confirms, with a larger sample size and higher resolution PET scanning, our earlier report that elevated DA rel is a primary defect in TS. The finding of decreased SERT BP, and the possible elevation in 5-HT 2A R in individuals with TS who had increased DA rel , suggest a condition of increased phasic DA rel modulated by low 5-HT in concomitant OCD.

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Section: Discussionsupporting

confidence: 63%

“…Ever since the original DA hypothesis for TS was proposed (Singer et al, 1982), the underlying dopaminergic deficit leading to TS dysfunction has eluded investigators. Thus, despite the many attempts to characterize TS, Motor tics, phonic tics, and impairment were measured using the YGTSS (Leckman et al, 1989).…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of Dopaminergic and Serotonergic Neurotransmission in Tourette Syndrome: Clues from an In Vivo Neurochemistry Study with PET

Wong

Brašić

Singer

et al. 2007

Neuropsychopharmacol

231

172

View full text Add to dashboard Cite

show abstract

“…The DA hypothesis of TS was originally proposed nearly 30 years ago [617], and has been corroborated by post-mortem data [618]; however the identification of an underlying DA deficit leading to dysfunction in TS has proven to be elusive [619]. Available evidence suggests that a phasic DA imbalance, similar to that seen in schizophrenia, may help to explain the pathophysiology of TS [619,620].…”

Section: Reviewmentioning

confidence: 99%

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Dichter

Damiano

Allen

2012

J Neurodevelop Disord

254

207

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This review summarizes evidence of dysregulated reward circuitry function in a range of neurodevelopmental and psychiatric disorders and genetic syndromes. First, the contribution of identifying a core mechanistic process across disparate disorders to disease classification is discussed, followed by a review of the neurobiology of reward circuitry. We next consider preclinical animal models and clinical evidence of reward-pathway dysfunction in a range of disorders, including psychiatric disorders (i.e., substance-use disorders, affective disorders, eating disorders, and obsessive compulsive disorders), neurodevelopmental disorders (i.e., schizophrenia, attention-deficit/hyperactivity disorder, autism spectrum disorders, Tourette’s syndrome, conduct disorder/oppositional defiant disorder), and genetic syndromes (i.e., Fragile X syndrome, Prader–Willi syndrome, Williams syndrome, Angelman syndrome, and Rett syndrome). We also provide brief overviews of effective psychopharmacologic agents that have an effect on the dopamine system in these disorders. This review concludes with methodological considerations for future research designed to more clearly probe reward-circuitry dysfunction, with the ultimate goal of improved intervention strategies.

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“…Do ponto de vista neuroquímico, diversas hipó-teses sugerem o envolvimento do sistema dopaminérgico na patogênese da ST, visto que os neurolépticos, antagonistas da dopamina, são considerados efetivos no tratamento desta doença, por promover grande redução dos tiques (Singer et al, 1982;Golden, 1988;Shapiro et al, 1989;Singer, 1997 (Pauls, 2001). Devido ao fato de não se ter determinado, ainda, todos os fatores envolvidos no quadro neurológico anormal da ST, não se pode excluir a possibilidade da mesma ser uma síndrome multicausal.…”

Section: Etiologia Aspectos Neurobiológicos E Patologias Associadasunclassified

Tourette: por dentro da síndrome

Loureiro¹,

Matheus-Guimarães²,

Santos³

et al. 2005

Rev. psiquiatr. clín.

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ResumoA síndrome de Tourette (ST) é uma patologia de comprometimento psicossocial que acarreta alterações significativas na vida dos seus portadores e respectivos familiares. Este artigo aborda diversos aspectos relacionados a esta doença, incluindo etiologia, epidemiologia, aspectos neurobiológicos, quadro clínico, diagnóstico, patologias associadas e tratamento (clássico e alternativo). Neste trabalho, ainda comparamos a ST com outras doenças, envolvendo tiques e mencionamos as associações de apoio aos pacientes portadores de ST, que auxiliam no tratamento e na socialização do paciente afetado.Palavras-chave: Síndrome de Tourette, tiques, AST, diagnóstico, patologia. AbstractTourette syndrome is a disorder associated with a variety of psycho-and social problems, which affects not only the patients but also their family life. The aim of this work is to review aspects involving etiology, epidemiology, neurobiology, symptomatology, diagnosis, and treatment (classic and alternative). We also compare the Tourette syndrome with others diseases involving tics and cite the organizations that help the patients and contribute to their treatment and socialization.

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Dopaminergic dysfunction in tourette syndrome

Cited by 167 publications

References 25 publications

Mechanisms of Dopaminergic and Serotonergic Neurotransmission in Tourette Syndrome: Clues from an In Vivo Neurochemistry Study with PET

Mechanisms of Dopaminergic and Serotonergic Neurotransmission in Tourette Syndrome: Clues from an In Vivo Neurochemistry Study with PET

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Tourette: por dentro da síndrome

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