Dopaminergic Dynamics Contributing to Social Behavior

Gunaydin, Lisa A.; Deisseroth, Karl

doi:10.1101/sqb.2014.79.024711

Cited by 57 publications

(45 citation statements)

References 38 publications

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“…These findings resonate well with other studies in laboratory animals reporting increased activity in the mesolimbic dopaminergic system upon social interactions (Gunaydin and Deisseroth, 2014;Robinson et al, 2002Robinson et al, , 2011 and with genetic studies in humans showing an important role for striatal dopamine in processing appetitive socially relevant stimuli (Eisenegger et al, 2013;Enter et al, 2012). Thus, functional activity in the mesolimbic dopamine pathway has an important modulatory role in adaptive social behavior.…”

Section: Discussionsupporting

confidence: 91%

Dopaminergic Neurotransmission in the Nucleus Accumbens Modulates Social Play Behavior in Rats

Manduca

Servadio

Damsteegt

et al. 2016

Neuropsychopharmacol

115

102

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Social play behavior is a highly rewarding form of social interaction displayed by young mammals. Social play is important for neurobehavioral development and it has been found to be impaired in several developmental psychiatric disorders. In line with the rewarding properties of social play, we have previously identified the nucleus accumbens (NAc) as an important site of action for endocannabinoid and opioid modulation of this behavior. NAc dopamine has a well-known role in certain components of reward processes, such as incentive motivation. However, its contribution to the positive emotional aspects of social interactions is less clear. Therefore, we investigated the role of dopaminergic neurotransmission in the NAc in social play behavior in rats. We found that intra-NAc infusion of the dopamine releaser/ reuptake inhibitor amphetamine increased social play behavior that was dependent on activation of both D1 and D2 dopamine receptors. This increase in social play behavior was mimicked by intra-NAc infusion of the dopamine receptor agonist apomorphine, but not of the dopamine reuptake inhibitor GBR-12909. Blockade of either D1 or D2 NAc dopamine receptors reduced social play in animals highly motivated to play as a result of longer social isolation before testing. Last, blockade of NAc dopamine receptors prevented the playenhancing effects of endocannabinoid and opioid receptor stimulation. These findings demonstrate an important modulatory role of NAc dopaminergic neurotransmission in social play. Thus, functional activity in the mesolimbic dopamine pathway plays an important role in adaptive social development, whereas abnormal NAc dopamine function may underlie the social impairments observed in developmental psychiatric disorders such as autism, attention deficit hyperactivity disorder or early-onset schizophrenia.

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Section: Discussionsupporting

confidence: 91%

Dopaminergic Neurotransmission in the Nucleus Accumbens Modulates Social Play Behavior in Rats

Manduca

Servadio

Damsteegt

et al. 2016

Neuropsychopharmacol

115

102

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“…The midbrain dopamine system has a long‐standing role in reward processing and affiliative social behavior, and is frequently reported as a site of isolation‐induced adaptation. The ventral tegmental area (VTA) dopamine neurons project to multiple regions including the striatum, prefrontal cortex (PFC), and basolateral amygdala (BLA), with the VTA–NAc pathway being particularly well associated with social reward .…”

Section: Homeostatic Response To Social Deficit: Engaging Social Motimentioning

confidence: 99%

Neural mechanisms of social homeostasis

Matthews

Tye

2019

Annals of the New York Academy of Sciences

126

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Social connections are vital to survival throughout the animal kingdom and are dynamic across the life span. There are debilitating consequences of social isolation and loneliness, and social support is increasingly a primary consideration in health care, disease prevention, and recovery. Considering social connection as an “innate need,” it is hypothesized that evolutionarily conserved neural systems underlie the maintenance of social connections: alerting the individual to their absence and coordinating effector mechanisms to restore social contact. This is reminiscent of a homeostatic system designed to maintain social connection. Here, we explore the identity of neural systems regulating “social homeostasis.” We review findings from rodent studies evaluating the rapid response to social deficit (in the form of acute social isolation) and propose that parallel, overlapping circuits are engaged to adapt to the vulnerabilities of isolation and restore social connection. By considering the neural systems regulating other homeostatic needs, such as energy and fluid balance, we discuss the potential attributes of social homeostatic circuitry. We reason that uncovering the identity of these circuits/mechanisms will facilitate our understanding of how loneliness perpetuates long‐term disease states, which we speculate may result from sustained recruitment of social homeostatic circuits.

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“…Thus, pharmacological blockade of D2R in the prefrontal cortex (PFC) selectively impaired social novelty discrimination 61 , while contrarily, blockade of dopamine D3 receptors (D3R) improved social memory and enhanced social novelty discrimination 61,62 . Finally, a similar enhancement in social recognition was observed following dopamine D1 receptor (D1R) activation in the PFC and the Nucleus Accumbens (NAc) 63 where pro-social behavior required intact D1R signaling 64 .…”

Section: Discussionmentioning

confidence: 78%

“…Social interaction is a complex behavior that critically relies on the integrity of midbrain DA ventral tegmental area (VTA) neurons [64][65][66] . The dissection of neural circuits regulating social interaction indicate that several neural pathways converging onto different VTA DA neurons may regulate distinct components of social behaviors.…”

Section: Discussionmentioning

confidence: 99%

Cerebellar dopamine D2 receptors regulate preference for social novelty

Cutando

Puighermanal

Castell

et al. 2019

Preprint

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The cerebellum, a primary center involved in the control of sensorimotor tasks, also contributes to higher cognitive functions including reward, emotion and social interaction. The regulation of these behaviors has been largely ascribed to the monoaminergic system in limbic regions.However, the contribution of cerebellar dopamine signaling in the modulation of these functions remains largely unknown due to the lack of precise characterization of cerebellar dopaminoceptive neurons. By combining cell type-specific transcriptomic and histological analyses, 3D imaging and electrophysiology we demonstrate that cerebellar dopamine D2 receptors (D2R) in mice are preferentially expressed in Purkinje cells (PCs). While activation of D2R regulate synaptic efficacy onto PCs, their deletion or overexpression in PCs bidirectionally controls preference for social novelty without affecting motor functions.Altogether, these findings demonstrate novel D2R's roles in PC function and causally link cerebellar D2R levels of expression to social behaviors.

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Dopaminergic Dynamics Contributing to Social Behavior

Cited by 57 publications

References 38 publications

Dopaminergic Neurotransmission in the Nucleus Accumbens Modulates Social Play Behavior in Rats

Dopaminergic Neurotransmission in the Nucleus Accumbens Modulates Social Play Behavior in Rats

Neural mechanisms of social homeostasis

Cerebellar dopamine D2 receptors regulate preference for social novelty

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