1980
DOI: 10.1016/0006-8993(80)90136-5
|View full text |Cite
|
Sign up to set email alerts
|

Dopaminergic component of [3H]spiroperidol binding in the rat anterior cerebral cortex

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

1
7
0

Year Published

1981
1981
2012
2012

Publication Types

Select...
5
5

Relationship

0
10

Authors

Journals

citations
Cited by 50 publications
(8 citation statements)
references
References 11 publications
1
7
0
Order By: Relevance
“…In the D2 binding system, which appeared to have a dopaminergic distribution in tissue areas (i.e., sites detectable only in regions with dopaminergic innervation), binding isotherms and Scatchard plots became monophasic and revealed similar low Kd values (0.05-0.1 nM) in areas where the D2 site was present. Although it may seem surprising that no D2 sites were detected in the frontal cortex, the present results are consistent with those of other workers, who have failed to detect dopaminergic [3H]spiperone binding in whole frontal cortex (6,9,10); when dopaminergic areas of the frontal cortex are specifically dissected out, however, D2-type binding is detected (17 (20 …”
supporting
confidence: 82%
“…In the D2 binding system, which appeared to have a dopaminergic distribution in tissue areas (i.e., sites detectable only in regions with dopaminergic innervation), binding isotherms and Scatchard plots became monophasic and revealed similar low Kd values (0.05-0.1 nM) in areas where the D2 site was present. Although it may seem surprising that no D2 sites were detected in the frontal cortex, the present results are consistent with those of other workers, who have failed to detect dopaminergic [3H]spiperone binding in whole frontal cortex (6,9,10); when dopaminergic areas of the frontal cortex are specifically dissected out, however, D2-type binding is detected (17 (20 …”
supporting
confidence: 82%
“…38 The same effect can be produced by endogenous DA, as evidenced by the suppression of PFC discharge in response to the VTA stimulation. 39,40 Although both D1-like and D2-like receptors are present in the PFC, 43,44 the suppressant effect of DA was shown to be mediated by the latter, as selective blockade of D2-like but not D1-like receptors reversed this action. 29,41 It was previously documented that the PPX-induced activation of somatodendritic D2 autoreceptors in the VTA led to the decrease in the firing rate of DA neurons, driven by the negative feedback mechanism exerted by the cell body D2 auto receptors.…”
Section: Discussionmentioning
confidence: 99%
“…The receptor population defined as site A comprises only 25% of the total, making these sites the more likely candidates to be receptors for 5-HT. Site A, however, had a higher affinity for dopamine than (27). In addition, receptors in the frontal cortex have 1/60th the affinity for domperidone compared to either of the two classes of striatal sites.…”
mentioning
confidence: 96%